Published: 2018-09-22

A myriad of fat

Abraham A. Kodiatte, Jubbin J. Jacob


Hypertriglyceridemia is a familiar issue a physician and his patients face. Writing a prescription for the same may be effortless, but without a thorough evaluation, we may miss out on a number of concealed diseases. Treating the underling secondary disease, avoids an unnecessary pill burden, eventually decreasing healthcare costs also. Unearthing prevalent diseases like diabetes mellitus (DM) is rewarding in its own way and pays dividends multifold. The physician must be aware that secondary causes of hypertriglyceridemia manifesting as lipemia can commonly be seen in disorders like obesity, primary hypothyroidism and DM. The studied patient presented to us obviously shaken with a long history of weight gain and lipemia during a blood draw. She turned out to have the commonest risk factors for hypertriglyceridemia - Obesity, hypothyroidism and DM causing the alarming lipemia. It was an oddly interesting presenting symptom of hypertriglyceridemia, obesity, hypothyroidism and DM which resulted in an appropriate and prompt management of her underlying diseases.


Diabetes mellitus, Hypertriglyceridemia, Hypothyroidism, Lipemia

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Expert Panel on Detection E. Executive summary of the third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III). JAMA. 2001 May 16;285(19):2486.

Berglund L, Brunzell JD, Goldberg AC, Goldberg IJ, Sacks F, Murad MH, et al. Evaluation and treatment of hypertriglyceridemia: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metabol. 2012 Sep 1;97(9):2969-89.

Copeland KC, Zeitler P, Geffner M, Guandalini C, Higgins J, Hirst K, et al. Characteristics of adolescents and youth with recent-onset type 2 diabetes: the TODAY cohort at baseline. J Clin Endocrinol Metabo. 2011 Jan 1;96(1):159-67.

Ogawa D, Wada J, Makino H. Diabetic lipemia associated with acute pancreatitis in a patient with type 2 diabetes. J Diab Mellitus. 2011 Aug 31;1(03):54.

Howard BV. Lipoprotein metabolism in diabetes mellitus. J Lipid Res. 1987 Jun 1;28(6):613-28.

Nair S, Yadav D, Pitchumoni CS. Association of diabetic ketoacidosis and acute pancreatitis: observations in 100 consecutive episodes of DKA. Am J Gastroenterol. 2000 Oct;95(10):2795.

Rizos CV, Elisaf MS, Liberopoulos EN. Effects of thyroid dysfunction on lipid profile. Open Cardiovasc Med J. 2011;5:76.

Pearce EN. Hypothyroidism and dyslipidemia: modern concepts and approaches. Current Cardiol Repo. 2004 Nov 1;6(6):451-6.

Khan MA, Majumder I, Hoque M, Fariduddin M, Mollah FH, Arslan MI. Lipid profile in hypothyroid patients: a cross sectional Study. Med Today. 2013;25(1):21-4.

Brunzell JD. Clinical practice. Hypertriglyceridemia. N Engl J Med. 2007 Sep 6;357(10):1009-17.