Published: 2018-05-22

Correlation between association of hypothyroidism and cardiovascular risk indices

Rajendra Datt Mathur, Rameshwar Prasad Gupta, Deepak Gupta, Reenika Mathur, Ajay Kumar Bhargav


Background: Association of hypothyroidism and cardiovascular diseases are important in development of Atherosclerosis. Hypothyroidism and sub clinical hypothyroidism reported highly risk factors due to lipid levels dearranged. Present study to demonstre of correlation of hypothyroidism and cardiovascular disease.

Methods: The present study has carried out in the department of medicine and Biochemistry SRG Hospital and associated hospital, Jhalawar Medical College Jhalawar (Raj.) Total 100 Hypothyroidism cases and 100 euthyroidism subject were included in the study Information regarding clinical history were recorded in self Constructed present questionnaires Patients were examined and estimated TSH, T3, T4 total Cholesterol, LDLc, HDCc, TG data were analyzed by SPPS version 20.0.

Results: Present study demonstrated increased levels of total cholesterol, LDH, VLDLC and TG and decreased level of HDLC and increased TSH level and decreased T3 and T4 Level in hypothyroidism cases when compared with euthyroid cases It was found significant.

Conclusions: In present study hypothyroidism and hormone Level (TSH, T3, T4) and lipid level dearranged values are associated with development cardiovascular disease atherosclerosis.


Cardiovascular disease, Hypothyroidism, Lipid profile, Thyroid profile

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Kottagi S, Jamble T, Deshpande S. Cardiovascular disease risk factors and its association with subclinical hypothyroidism. Int J Clin Biochem Res. 2017;4(4):435-8.

Ruhla S, Weickert MO, Arafat AM, Osterhoff M, Isken F, Spranger J, Schöfl C, Pfeiffer AF, Möhlig M. A high normal TSH is associated with the metabolic syndrome. Clin Endocrinol. 2010 May 1;72(5):696-701.

Hunter I, Greene SA, MacDonald TM, Morris AD. Prevalence and aetiology of hypothyroidism in the young. Arch Dis Childhood. 2000;83(3):207-10.

Mullur R, Liu YY, Brent GA. Thyroid hormone regulation of metabolism. Physiol Rev. 2014 Apr;94(2):355-82.

Burtis CA, Ashwood ER, Bruns DE. Tietz textbook of clinical chemistry and molecular diagnostics-e-book. Elsevier Health Sciences; St. Louis, USA, 5th Ed. 2012;2238:909.

Tumbridge WM, Evered DC, Hall R, Appleton D, Brewis M, Clark F, et al. The spectrum of thyroid disease in a community: The Wickham survey. Clin Endrocrinol. 1977;7:481-93.

Bindels AJ, Westendorp RG, Frolich M, Seidell JC, Blokstra A, Smelt AH. The prevalence of subclinical hypothyroidism at different total plasma cholesterol levels in middle aged men and women: a need for case-finding? Clin Endocrinol. 1999;50:217-20.

Harris KB, Pass KA. Increase in congenital Hypothyroidism in New York state and in the Unites States. Molecular Genet Metab. 2007;91:268-77.

Virtanen M, Mäenpää J, Pikkarainen J, Pitkänen L, Perheentupa J. Aetiology of congenital hypothyroidism in Finland. Acta Paediatrica. 1989 Jan 1;78(1):67-73.

Vassart G, Dumont JE. Thyroid dysgenesis: multigenic or epigenetic… or both?. Endocrinology. 2005 Dec 1;146(12):5035-7.

Udiong CE, Udoh AE, Etukudoh ME. Evaluation of thyroid function in diabetes mellitus in Calabar, Nigeria. Indian J Clin Biochem. 2007 Sep 1;22(2):74-8.

Suzuki Y, Nanno M, Gemma R, Tanaka I, Taminato T, Yoshimi T. The mechanism of thyroid hormone abnormalities in patients with diabetes mellitus. Nihon Naibunpi Gakkai Zasshi. 1994 May;70(4):465-70.