DOI: http://dx.doi.org/10.18203/2349-3933.ijam20181661

Lipid profiles among Plasmodium falciparum infected, non malarial febrile patients and volunteers

Bipin K. Kullu, Chakradhar Majhi, Butungeshwar Pradhan, Deepak K. Swain

Abstract


Background: Acute falciparum Malaria infected patients show wide ranges of metabolic derangement including changes in serum lipid profiles. The exact mechanisms of this derangement in serum lipid profiles are still poorly understood. Objective was to study the lipid profiles among acute plasmodium falciparum infected patients.

Methods: It was a Prospective observational comparative study. A total of 100 patients were consecutively taken in the study. Fifty Non- malaria febrile cases and 50 healthy volunteers were taken as control group. Baseline lipid profiles were estimated in all cases at the time of admission and at the end of one week. Data were collected and analyzed.

Results: There were 100 diagnosed cases of falciparum malaria and 50 non malarial febrile and 50 healthy volunteers taken as control group. Complications was present in 50 and 50 were uncomplicated. Serum total cholesterol, HDL and LDL levels were significantly low in falciparum malaria patients, and serum TG and VLDL levels were higher than control. There were no significant changes in mean serum lipids profiles in survived and deaths cases.

Conclusions: The derangement in lipid profiles in falciparum malaria was characteristic and specific for the disease. Characteristic changes were lower HDL, LDL and total cholesterol levels and higher TG and VLDL levels in comparison to control groups. Changes are more pronounced in complicated falciparum Malaria and persisting till the end of the week. These findings may be of diagnostic and prognostic value.


Keywords


Acute Plasmodium falciparum, Malaria infection, Lipid profiles

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References


Mohanty S, Mishra SK, Das BS, Satpathy SK, Mohanty D, Pattanaik JK et al. Altered plasma lipid pattern in falciparum malaria. Ann Trop Med. Parasitol. 1992;86(6):601-6.

Faucher JF, Ngou-Milama E, Missinou MA, Ngomo R, Kombila M, Kresner PG. The impact of malaria on common lipid parameters. Parasitol Res. 2002;88:1040-3.

Bansal D, Bhatti HS, Sehgal R. Role of cholesterol in parasitic infection. Lipid Health Dis. 2005;4:10.

Baptista JL, Vervoort T, Van der stuyft P. Changes in plasma lipid levels as of function of Plasmodium falciparum infection in Sao Tome. Parasite 1996;3(4):335-40.

Akgun S, Ertel NH, Mosenthal A, Oser W. Postsurgical reduction of serum lipoproteins: Interleukin-6 and the acutephase response. J Lab Clin Med. 1998;131:103-8.

Coombes EJ, Shakespeare PG, Batstone GF. Lipoprotein changes after burn injury in man. J Trauma. 1980;20:971-5.

Budd D, Ginsberg H. Hypocholesterolemia and acute myelogenous leukemia. Association between disease activity and plasma low-density lipoprotein cholesterol concentrations. Cancer. 1986;58:1361-5.

Rosenson RS. Myocardial injury: The acute phase response and lipoprotein metabolism. J Am Coll Cardiol. 1993;22:933-40.

Visser BJ, de Vries SG, Vingerling R, Gritter M, Kroon D, Kraan RB et al. Serum lipids and lipoproteins during uncomplicated malaria: a cohort study in Lambaréné, Gabon. Am J Trop Med Hyg. 2017 May 3;96(5):1205-14.

Aknabi OM, Badaki JA, Adeniran OY, Olotu. Effect ofmalaria infection on oxidative stress and lipid profiles in pregnant women. Journal of Medicine and Medical Sciences. 2013;4(3):128-33.

Visser BJ, Wieten RW, Nagel IM, Grobusch MP. Serum lipids and lipoproteins in malaria: a systematic review and meta-analysis. Malaria J. 2013;12(1):442.

Jacob EA. Assessment of altered plasma lipid pattern in Plasmodium falciparum malaria infected and non infected individuals. Int J Haematol Disorders. 2014;1(1):27-30.

Warjri SB, Ete T, Mishra A, Barman B, Mishra J, Pala S et al. Association between Clinical Malaria and Blood Lipids in North Eastern India. BJMMR. 2016;16(1):1-7.