DOI: http://dx.doi.org/10.18203/2349-3933.ijam20162503

High sensitivity C-reactive protein in metabolic syndrome

Prakash Kikkeri Gowdaiah, Mamatha T. R., Dyaneshwar Nirgude, Prakash Basappa Hosamani

Abstract


Background: Presence of metabolic syndrome in an individual substantially increases his risk of developing cardiovascular disease and type 2 diabetes mellitus. Occurrence of both obesity and type 2 DM have reached epidemic proportions in India. Metabolic syndrome is considered to be a proinflamatory state associated with low grade systemic inflammation. C- reactive protein is a robust biomarker of this chronic systemic inflammation. Higher values of  high sensitivity C- reactive protein (hs-CRP) are associated with metabolic syndrome and its components and provides additional prognostic information on future development of cardiovascular events in them.

Methods: 50 patients aged 18 years and above with metabolic syndrome, and 50 age and sex matched controls attending OPD or admitted to medicine department wards of Bangalore Medical College were enrolled for this cross sectional study. The new IDF criteria were used for the diagnosis of metabolic syndrome. A fasting blood sample was drawn for estimation of hs-CRP, blood glucose and lipid profile. Waist circumference, height and weight were measured at the same time. The results were tabulated and analysed.

Results: There was a statistically significant difference in values of various demographic parameters like BMI, waist circumference, BP and biochemical parameters like blood sugar, lipid profile   between cases and controls. Patients with metabolic syndrome had higher mean value of hs-CRP (8.3±1.04 Vs 1.6±0.79mg/l) with a p value <0.001.

Conclusions: Patients with metabolic syndrome had significantly higher levels of hs-CRP when compared to controls and hs-CRP levels increased linearly with increasing number of metabolic syndrome components. Hence hs-CRP can probably be used as a surrogate marker of chronic inflammation in patients with metabolic syndrome.


Keywords


High sensitivity C-reactive protein, Metabolic syndrome, Cytokines

Full Text:

PDF

References


Reaven GM. The insulin resistance syndrome: definition and dietary approaches to treatment. Ann Rev Nutr. 2005;25:391-406.

Devaraj S, Rosenson RS, Jialal I. Metabolic syndrome: an appraisal of the pro-inflammatory and procoagulant status. Endocrinol Metab Clin North Am. 2004;33:431-53.

Ridker PM, Wilson PW, Grundy SM. Should C-reactive protein be added to metabolic syndrome and to assessment of global cardiovascular risk. Circulation. 2004;109:2818-25.

Bergman RN, Van Citters GW, Mittelman SD, Dea MK, Hamilton- Wessler M, Kim SP, Ellmerer M. Central role of the adipocyte in the metabolic syndrome. J Investig Med. 2001;49:119–26.

You T, Yang R, Lyles MF, Gong D, Nicklas BJ. Abdominal adipose tissue cytokine gene expression: relationship to obesity and metabolic risk factors. Am J Physiol Endocrinol Metab. 2005;288:741–7.

Ridker PM, Pare G, Parker A, Loci related to metabolic-syndrome pathways including LEPR, HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: the Women‘s Genome Health Study. Am J Hum Genet. 2008;82:1185–92.

Ridker PM, Wilson PW, Grundy SM. Should C-reactive protein be added to metabolic syndrome and to assessment of global cardiovascular risk. Circulation. 2004;109:2818–25.

Paul M Ridker. C-Reactive Protein: A Simple Test to Help Predict Risk of Heart Attack and Stroke. Circulation. 2003;108:81-5.

International Diabetes Federation. Worldwide definition of the metabolic syndrome. Available at: http://www.idf.org/webdata/docs/IDF_Meta- syndrome_definition.pdf. Accessed August 24, 2005.

Vidyasagar S, Abdul razak UK, Prashanth CK, Varma DM, Bairy KL. Highly sensitive C reactive protein in metabolic syndrome. JIACM. 2013;14:230-4.

Bo S,Gentile L, Ciccone G, Baldi C, Benini L, Dusio F, et al. The metabolic syndrome and high c reactive protein: prevelance and difference by sex in a southern European population based cohort. Diabetes Metab Res Rev. 2005;21;515-24

Mahajana A, Jaiswala A, Tabassum R, Podder A, Ghosh S, Madhu SV, et al. Elevated levels of C-reactive protein as a risk factor for Metabolic Syndrome in India. Atherosclerosis. 2012;220:275–8.