Study of clinical and nerve conduction study correlation in patients of diabetic neuropathy in diabetes mellitus type 2


  • Manish Patil Department of Medicine, Pt. Jawaharlal Nehru Memorial Medical College, Chhattisgarh, India
  • Avon Kumar Dhruw Department of Medicine, Pt. Jawaharlal Nehru Memorial Medical College, Chhattisgarh, India
  • Shashank Gupta Department of Medicine, Pt. Jawaharlal Nehru Memorial Medical College, Chhattisgarh, India



Cross-sectional study, Diabetic polyneuropathy (DPN), Nerve conduction studies


Background: Diabetes mellitus (DM) is a metabolic disorder characterized by chronic hyperglycemia with disturbance of carbohydrate, fat, and protein metabolism resulting from defects in insulin secretion, insulin action or both with an increased risk of neuropathy. Early diagnosis and management of diabetic polyneuropathy (DPN) are crucial as failure to diagnose can lead to serious consequences, including disability and amputation. Present study aimed at investigating the demographic profile and correlation of clinical features with nerve conduction studies in patients with diabetic neuropathy in type 2 diabetes mellitus.

Methods: The cross-sectional study design with total 66 patients of type 2 DM were selected in 30 to 60-year age groups, from Pt. Jawaharlal Nehru Memorial Medical College, Department of Medicine, Raipur (C.G.) (Pt. JNMMC) and associated hospital. Descriptive statistics and χ2 test were used for analysing the data.

Results: Total 66 patients were selected, Most of the patients are presenting with tingling sensation (n=64, 97.0%) and burning feet (n=52, 78.8%), NCV is mostly absent in the tibial nerve (n=52, 78%), sural nerve (n=63, 95.5%) and planter nerve (n=41, 62.1%) while it is largely normal in median nerve (n=54, 81.8%) and ulner nerve (n=61, 92.4%). Tingling sensation, burning feet, diminished vibration sensation and diminished light touch are significantly associated (p=0.00) with NCV in different nerves.

Conclusions: Limitations of study includes small sample size, lack of general population, and a control group. Diabetes mellitus is a chronic illness with an increased risk of neuropathy. NCS having high sensitivity and specificity for detection of DPN. Understanding the NCS and its correlates in patients with DPN is crucial for early detection and development of effective management and strategies to prevent its complications.


World Health Organization. Definition, diagnosis and classification of diabetes mellitus and its complications: report of a WHO consultation. Part 1, Diagnosis and classification of diabetes mellitus, 1999.

American Diabetes Association. 2. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes-2018. Diabetes Care. 2018 1;41(Supplement 1):S13-27.

DeFronzo RA, Ferrannini E, Groop L, Henry RR, Herman WH, Holst JJ, Simonson DC. (2015). Type 2 diabetes mellitus. Nat Rev Dis Primers. 2015;1:1509.

Inzucchi SE, Bergenstal RM, Buse JB, Diamant M, Ferrannini E, Nauck M, et al. Management of hyperglycemia in type 2 diabetes, 2015: a patient-centered approach: update to a position statement of the American diabetes association and the European association for the study of diabetes. Diabetes Care. 2015;38(1):140-9.

Chen L, Magliano DJ, Zimmet PZ. The worldwide epidemiology of type 2 diabetes mellitus-present and future perspectives. Nat Rev Endocrinol. 2012;8(4):228.

Garber AJ, Abrahamson MJ, Barzilay JI, Blonde L, Bloomgarden ZT, Bush MA, et al. Consensus statement by the American association of clinical endocrinologists and American college of endocrinology on the comprehensive type 2 diabetes management algorithm-2016 executive summary. Endocrine Practice. 2016;22(1):84-113.

Sen S, Chakraborty R, De B. Diabetes Mellitus in 21st century. Springer; 2016 Jul 25.

Malandrino N, Wu WC, Taveira TH, Whitlatch HB, Smith RJ. Association between red blood cell distribution width and macrovascular and microvascular complications in diabetes. Diabetologia. 2012;55(1):226-35.

Boulton AJ, Malik RA. Diabetic neuropathy. Medical Clinics. 1998;82(4):909-29.

Bansal D, Gudala K, Muthyala H, Esam HP, Nayakallu R, Bhansali A. Prevalence and risk factors of development of peripheral diabetic neuropathy in type 2 diabetes mellitus in a tertiary care setting. J Diab Investigat. 2014;5(6):714-21.

Kim SS, Won JC, Kwon HS, Kim CH, Lee JH, Park TS, et al. Prevalence and clinical implications of painful diabetic peripheral neuropathy in type 2 diabetes: results from a nationwide hospital-based study of diabetic neuropathy in Korea. Diabetes Res Clin Pract. 2014;103(3):522-9.

Kiani J, Azizkhani H, Kosarifard S. The prevalence and associated risk factors of peripheral diabetic neuropathy in Hamedan, Iran. Arch Iranian Med. 2013;16(1):17.

Albers JW, Pop-Busui R. Diabetic neuropathy: mechanisms, emerging treatments, and subtypes. Current Neurol Neurosci Reports. 2014;14(8):473.

Martin CL, Albers JW, Pop-Busui R, DCCT/EDiC research Group. Neuropathy and related findings in the diabetes control and complications trial/epidemiology of diabetes interventions and complications study. Diabetes Care. 2014;37(1):31-8.

Malik RA. Which test for diagnosing early human diabetic neuropathy?. Diabetes. 2014;63(7):2206-8.

Kimura J. Nerve conduction studies. Oxford Textbook of Clinical Neurophysio. 2017:49.

Chatzikosma G, Pafili K, Demetriou M, Vadikolias K, Maltezos E, Papanas N. Evaluation of sural nerve automated nerve conduction study in the diagnosis of peripheral neuropathy in patients with type 2 diabetes mellitus. Arch Med Sci: AMS. 2016;12(2):390.

Squintani G, Zoppini G, Donato F, Pineschi E, Donini D, Stoico V, et al. Antidromic sensory nerve conduction study of the digital branches of the medial plantar nerve: a novel method to detect early diabetic sensory axonal polyneuropathy. Muscle Nerve. 2014;50(2):193-9.

Gul S, Dar MA, Ali A, Ashraf A, Qadri S. Prevalence of peripheral neuropathy and pattern of involvement on nerve conduction study in patients of type 2 diabetes mellitus with clinical symptoms of peripheral neuropathy in Kashmiri population: a hospital-based study. Imperial J Interdisciplinary Res. 2017;3(2).






Original Research Articles