A study of clinical profile and complication of malaria in a tertiary care centre in South-eastern region of Rajasthan, India
DOI:
https://doi.org/10.18203/2349-3933.ijam20162505Keywords:
P. Vivax, P. Falciparum, Complicated malaria, Fever, SplenomegalyAbstract
Background: Malaria continues to be one of the important public health problems in India. As per World Health Organization report 2015, South East Asian Region bears the second largest burden of malaria (10%), only being next to African region (88%).The present study is aimed at to study clinical profile and complications, in a tertiary care hospital.
Methods: A total of 100 cases were included in the study that admitted at NMCH, Kota and identified positive for malaria parasites on peripheral smear examination with conventional microscopy and / or by rapid diagnostic test.
Results: predominant symptoms were fever (100%), vomiting (52%), headache (34%), myalgia (28%) and jaundice (27%) and signs were splenomegaly (75%), pallor (57%), icterus (28%), hepato-splenomegaly (19%), and hepatomegaly (04%). In this study, 82% patients suffered from uncomplicated malaria and 18% from complicated malaria.
Conclusions: Malaria is responsible for major health concern in South-eastern region of Rajasthan and is found to affect comparatively the younger adult population. P. Vivax was the major parasite type causing malaria and most of the complications were due to P. falciparum.
References
World Health Organization. World Malaria report 2015. Available at www.who.int/ malaria/ media/ world_malaria_report_2015/. Accessed on 15th feb 2016.
World Health Organization. World Malaria report 2011. Available at www.who.int/ malaria/ world_malaria_report_2011/. Accessed on 15th October 2012.
Saha B. Severe Falciparum Malaria-redicting The Outcome. Clinical Medicine Update. 2013;21:469-74.
White NJ, Breman JG. Harrison’s Principles of Internal Medicine.18th edition. Vol I. The McGraw-Hill Cmpanies, Inc. US:1688
Jermiah ZA, Uko EK. Depression of platelet counts in apparently healthy children with malaria infection in a Nigerian metropolitan city. Platelets. 2007;18(6):469-71.
Mohapatra MK, Padhiary KN, Mishra DP, Sethy G. Atypical manifestations of Plasmodium vivax malaria. Indian J Malariol. 2002;39:18-25.
Kochar DK, Saxena V, Singh N, Kochar SK, Kumar SV, Das A. Plasmodium vivax malaria. Emerg Infect Dis. 2005;11:132-4.
Kochar DK, Pakalapati D, Kochar SK, Sirohi P, Khatri MP, Kochar A. An unexpected cause of fever and seizures. Lancet. 2007;370: 908.
Nautiyal A, Singh S, Parmeshwaran G, Disalle. Hepatic dysfunction in a patient with Plasmodium vivax infection. Med Gen Med. 2005;7: 8.
Kumar S, Melzer M, Dodds P, Watson J, Ord R. P. vivax malaria complicated by shock and ARDS. Scand J Infect Dis. 2007;39:255-6.
Parren A, Beretta F, Schubarth P. ARDS in Plasmodium vivax malaria. Schweiz Med Wochenschr. 1998;128:1020-3.
Rifakis PM, Hernandez O, Fernandez CT, Rodriguez-Morales AJ, Von A, Franco-Paredes C. Atypical Plasmodium vivax malaria in a traveler: bilateral hydronephrosis, severe thrombocytopenia and hypotension. J Travel Med. 2008;15:119-21.
Oh MD, Shin H, Shin D, Kim U, Lee S, Kim N, Choi MH et al. Clinical features of vivax malaria. Am J Trop Med Hyg. 2001;65:143-6.
Kaur D, Wasir V, Gulati S, Bagga A. Unusual presentation of Plasmodium vivax malaria with severe thrombocytopenia and acute renal failure. J Trop Pediatr. 2007;53:210-2.
Mehta KS, Halankar AR, Makwana PD, Torane PP. Severe acute renal failure in malaria. J Postgrad Med. 2001;47:24-6.
Prakash J, Singh AK, Kumar NS, Saxena RK. Acute renal failure in Plasmodium vivax malaria. JAPI. 2003;51:265-7.
Makkar RP, Mukhopadhyay S, Monga A. P. vivax malaria presenting with severe thrombocytopenia. Braz J Infect Dis.2002;6:263-5.
Kochar DK, Kochar SK, Agrawal RP, Sabir M, Nayak KC, Agrawal TD, et al. The changing spectrum of severe P. falciparum malaria: a clinical study from Bikaner (North West India). J Vector Borne Dis. 2006;43:104-8.
Mohapatra MK. The Natural history of complicated P. falciparum malaria; a prospective study. J Assoc. Physicians India. 2006;54:848-53.
World Health Organization. Guidelines for the treatment of malaria. Second Edition ed: World Health Organization. 2010.
Estacio RH, Edwin ER, CresswellS, Coronel RF, Alora AT. The Quantitative Buffy Coat technique (QBC) in early diagnosis of malaria: The Santo tomas University Hospital experience. Phil J Microbiol Infect Dis. 1993;22(2):56-9.
Devineni SB, Suneetha O, Harshavardhan N. “Study of Platelet Count in Malaria Patients and the Correlation between the Presence and Severity of Platelet Count with Type of Malaria”. Journal of Evolution of Medical and Dental Sciences 2015;4(67):11734-46.
Madhu M and Prakash PS. A study of clinical profile of malaria in a tertiary referral centre in South Canara. J Vect Borne Dis. 2006;43:29-33.
Suryawanshi A, Tungikar S. “A clinical profile of malaria.” International Journal of Recent Trends in Science And Technology. 2015;14(2):432-5.
Wasnik PN, Manohar TP, Humaney NR, Salkar HR. Study of Clinical Profile of Falciparum Malaria in a Tertiary Referral Centre in Central India. JAPI. 2012; 60.
Rao BS, Vani MS, Latha GJSL, Lavanya D. Incidence, severity, prognostic significance of thrombocytopenia in malaria. Int J Res Med Sci. 2015;3:116-21.
Kumar GV, Subrahmanyam DB, Kumar KH. Incidence and prognostic significance of thrombocytopenia in malaria. J of Evidence Based Med &Hlthcare, Pissn. 2015;2:1431-5.
Devrajani B, Uttra CKM. Severity of thrombocytopenia and prolonged bleeding time in Patients with Malaria. World Applied Sciences Journal. 2010;9(5):484- 8
Gopinathan VP, Ratla PK, Bhopte AG. Falciparum malaria in North Eastern Sector JAPI. 1981.
Murthy GL, SAhay RK, Srinivasan VR, Udapdhaya AC, Shantaram V, Gayatri K. clinical profile of falciparum malaria in a tertiary care hospital. J Indian Med Assoc. 2000;98(8):160-2,169.
Tamal D, Mohanti RK, Ravi K, Bhsagat BM. A typical presentation of falciparum malaria. JAPI. 1992;40(6):381-4.
Shah S, Ali L, Sattar RA, Aziz T, Ansari T, Ara J. Malarial Hepatopathy in Falciparum Malaria Journal of the College of Physicians and Surgeons Pakistan. 2009;19(6):367-70.
Nitya N, Aggarwal H, Sharma M, Singh M. systemic manifestations of malaria. JIACM. 2001;2(3).
Kochar DK, Agarwal P, Kochar SK et al. Hepatocyte dysfunction and hepatic encephalopathy in Plasmodium falciparum malaria. QJM. 2003;96:505-12
Limaye CS, Londhey VA, ST Nabar. The Study of Complications of Vivax Malaria in Comparison with Falciparum Malaria in Mumbai J.Asso.Physicianindia. 2012;60:15-7.
Patel DKN, Pradeep P, Surti MM, Agarwal SB. Clinical Manifestations of Complicated Malaria an Overview-Journal, Indian academy of clinical medicine. 2003;4(4):323-31.
Kochar DK, Das A, Kochar A, Middha S, Acharya J, Tanwar GS, et al. Thrombocytopenia in plasmodium falciparum, plasmodium vivax and mixed infection malaria- a study from Bikaner. Platelets. 2010;21(8):623-7.