Published: 2018-05-22

Prospective study of opportunistic infections among HIV infected patients in VSS Institute of Medical Science and Research, Burla, Sambalpur, Odisha, India

P. K. Bariha, M. K. Mohapatra, B. K. Kullu, P. C. Karua, S. B. Biswal, A. Thakur


Background: HIV destroys the CD4+T cells progressively thus making the HIV infected persons susceptible to a number of opportunistic infections (OIs).

Methods: The study was conducted in the Medicine Department and ART Centre, VIMSAR. It is a prospective study from July 2016 to September 2017.

Results: 86 patients register, detail history, clinical examination and investigation were done and then the data is complying in detail. Most of the patients were male (72%) male female ratio is 2.6:1. The majority of patients presented with fever, weight loss and anorexia seen in more than 73% of the study population.

Conclusions: (42%) cases belonged to the CD4+T cell count range of 101-200/µl with aCD4+T cell count of 183/µl, so there is increased chance of hospitalization in patients having CD4+T cell count below 200/µl. The most common OI was tuberculosis (51%) with pleural effusion as its commonest manifestation. The second most common OI was candidiasis (43%) with most cases suffering from oral candidiasis was seen to occur at higher CD4+T cell counts than tuberculosis.


Candidiasis, CD4 cell, HIV, Opportunistic infections (OIs), Tuberculosis

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Chakraborty N, Mukherjee A, Santra S, Sarkar RN, et al, Current trends of OIs among HIV infected patients from eastern India. JPN J Infect Dis. 2008;61:49-53.

Sharma SK, Kadhiravan T, Banga A, Goyal T, Bhatia I, Saha PK. Spectrum of clinical disease in a series of 135 hospitalized HIV- infected patients from North India. BMC Infect Dis. 2004;4:52.

Fauci AS, Lane HC. Human Immunodeficiency Virus Disease; AIDS and Related Disorder’, Harrison’s Principle of Internal Medicine,18th ed. McGraw Hill Medical companies. 2012;1542-64.

Patton GC, Coffey C, Sawyer SM, Viner RM, Haller DM, Bose K et al. Global patterns of mortality in young people: a systematic analysis of population health data. Lancet. 2009;374:9693.

Annual Report 2010-11, Department of AIDS Control, NACO, Ministry of Health and Family Welfare, Government of India.1-6.

Patel SD, Kinariwala DM, Javadekar TB, ‘Clinico-microbiological study of opportunistic infection in HIV seropositive patients. Ind J STD AIDS. 2011;32:90-3.

Chakravarty J, Mehta H, Parekh A, Attili SVS, Agrawal NR, Singh SP, et al Study on Clinico-epidemiological Profile of HIV Patients in Eastern India. J Assoc Physician India. 2006;54:854-7

Kumarasamy N, Vallabhaneri S,Timothy P Flannagan, Kenneth H Mayer, Suriti Solomon, et al, Spectrum of opportunistic infections amomg AIDS patients. Ind J Med Res. 2005;121:377-394.

Mulla SA, Patel MG, Motala N, Desai V, Shrivastava RK. A study of opportunistic infection in HIV seropositive patients. Indian J Commun Med. 2007;32:208-9.

Singh A, Bairy I, Shivananda PG, ‘Spectrum of opportunistic infections in AIDS cases’. NEJM. 2003;57:16-21.

Takalkar Anant A, Saiprasad GS, Prasad VG, Madhekar NS. Study of opportunistic infection in hiv seropositive patients admitted to Community Care Centre (CCC), KIMS, Narketpally. J Biomed Res. 2012;23:139-42.

Aggarwal A, Arora U, Bajaj R, Kumari K. ‘Clinicomicrobiological study in HIV seropositive patients’. J Indian Acad Clin Med. 2005;6:142-5.

Vaipayee M, Kanswal S, Seth P, Wig N. Spectrum of opportunistic infections and profile of CD4+ counts among AIDS patients in North India. Infection. 2003;31:336-40.

Chatterjee KD. parasitology protozoology and helminthology, 13th ed. CBS Publishers;2009:129-37.

Deivanayagam CN, Rajasekaran S, Senthilnathan V, Krishnarajsekhar R, Raja K, Chandrasekar C, et al. Clinico-radiological spectrum of tuberculosis among HIV seropositives: A Tambram study. Indian J Tuberc. 2001;48:123.

Dhungel BA, Dhungel KU, Easow JM, Singh YI ‘Opportunistic infection among HIV seropositive cases in Manipal Teaching Hospital, Pokhara, Nepal’. Kathmandu Univ Med J. 2008;6:335-9.

Anand KP, Sandip JT, Feroz DG. Clinical and laboratory profile of patients with TB/HIV coinfection: A case series of 50 patients. Lung India. 2011;28:93-6.

Baradkar VP, Karyakarte RP. Isolation and characterization of Candida species in Acquired Immunodeficiency syndrome. Indian J Med Microbiol. 1999;17:42-4.

Pfaller MA. Epidemiology and control of fungal infection. Clin Infect Dis. 1994;19:S8-13.

Gutierrez J, Morales P, Gonzalez MA, Quindos G. Candida dubliniensis, a new fungal pathogen. J Basic Microbiol. 2002;42:207-27.

Sangamesh MM, Gopal B, Kora SA, Biradar S, Renuprasad C. Study of opportunistic parasitic infections at various level of immunosuppression in HIV /AIDS patients presenting with diarrhoea. J Pharm Biomed Sci. 2012:20:1-3.

Rao AK, Sirwar SB, Indupalli AS, Mir BA. A study on opportunistic parasitic and fungal infections in HIV patients in rural Hospital at Sangareddy, Andhra Pradesh. Int J Biol Medical Res. 2012;3:2415-7.

Ayyagari A, Sharma AK, Prasad KN, Dhole TN, Kishore J, Chaudhary G. Spectrum of opportunistic infection in Human immunodeficiency virus (HIV) infected cases in tertiary care hospital. Ind J Med Microbiol. 1999;17:78-80.

Russian DA, Kovacs JA. Pneumocystis carinii in Africa. An emerging pathogen? Lancet. 1995;346:1242-3.

Manual on laboratory diagnosis of common opportunistic infections associated with HIV/AIDS. Baveja UK, Sokhey J, editors. National Institute of Communicable Disease and National AIDS Control Organisation. Feb 2001.

Nair SP, Moorthy KP, Suprasakan S. Clinico-epidemiological study of HIV patients in Trivendrum. Indian J Dermatol Venerol Leprol 2003; 69:100-3.

Shobhana A, Guha SK, Neogi DK. Mucocutaneous manifestations of HIV infection. Indian J Dermatol Venerol Leprol. 2004;70:82-6.

Shailaja VV, Pai LA, Mathur DR, Lakshmi V. Prevalence of bacterial and fungal agents causing lower respiratory tract infection in patients with human immunodeficiency virus infection. Indian J Med Microbiol. 2004;22:28-33.

Ghate MV, Tripathy SP, Kumar BK, Godbole SV, Chittake A, Nyayanirgune P et al. Rate of hospitalization and inpatient care costs for HIV-1-infected patients in Pune, India. National Med J IND. 2006;19:5-6.

Cunningham FG, Kenneth JL, Bloom SL, Hauth JC et al Medical and surgical complications of human immunodeficiency virus (HIV) infection, Williams obstetrics, 23rd ed. Mcgraw-Hill Medical Publication, 2010;59:1247-52.