DOI: http://dx.doi.org/10.18203/2349-3933.ijam20183123

Role of serum interleukin-6 in heart failure

Smita Amol Deokar, Sucheta P. Dandekar, Ganesh A. Shinde, Surekha S. Prabhu, Mugdha Patawardhan

Abstract


Background: A growing body of evidence suggests that inflammation plays the key role in different cardiovascular diseases. But very study has been done so far in relation to serum interleukin-6 in heart failure patients.  The aim of the study was to measure serum interleukin-6 in heart failure patients.

Methods: Total 22 heart failure patients and 22 age and sex matched controls were included in this study from August 2015 to June 2016 for serum analysis of interleukin-6.

Results: serum interleukin-6 was significantly [median(IQR) 14.3(26.2) pg/mL] increased in heart failure patients compared to age and sex matched controls [median(IQR) 0(2.4) pg/mL].

Conclusions: Even though little is known about function of interleukin-6 in heart failure patients, this study shows that increased level of IL-6 in heart failure patients plays an important role as a pro-inflammatory marker in development of cardiovascular disease i.e. heart failure.


Keywords


Cardiovascular disease, Enzyme-linked imunosorbent assay, Heart failure, Inflammatory markers

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References


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