Occupational exposure, drug toxicities and adherence to HIV post exposure prophylaxis: a cohort study at the teaching hospital in Erode district, Tamilnadu, India

Mohankumar Vedhanayagam, Senthilkumar Sengodan, Rajesh Rajagopalan


Background: Human immunodeficiency virus (HIV) infection to healthcare personals follows occupational exposure follows accidental needle stick injuries can be minimized less than <1% with post-exposure prophylaxis with antiretroviral drugs in time. Retrospective review of records of occupational exposure to HIV, analyse post exposure prophylaxis drug side effects and adherence.

Methods: On-going documentation of occupational exposures with known source of infection (HIV reactive) reported at IRT Perundurai Medical College Hospital, Erode district, Tamilnadu, India from January 2008 to March 2016 were reviewed.

Results: A total of 14 cases (4 males and 10 females) occupational exposure to HIV infections were documented. 9 interns, 13 needle stick injuries, 7 needle recapping, 8 mild exposure, 10 washing  with water or soap and water, 11 with less than one year of practical  experience,   10 completed the follow up were the common subdivisions. ZL for 12 and TLE for 2 were prescribed. Nausea and vomiting were the commonest and bothersome side effect. One intern stopped PEP after 4 days because of extensive nausea, vomiting and fatigue but all others completed PEP.

Conclusions: HCPs need to be given in-service training and mentoring regarding universal work precautions, management of occupational exposure, PEP, adverse events and management, and continued active follow‑up to ensure the adherence by mobile and social media. This is very helpful in curtailing the risk of occupational HIV sero-conversion.


Human immunodeficiency virus, Health care personnel, Occupational exposure, Post-exposure

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