Comparison of prediction of outcomes in upper GI bleed using non-endoscopic scoring systems

Authors

  • Nagaraja B. S. Department of Medicine, Bangalore Medical College and Research Institute, Bangalore, Karnataka, India
  • Vinay K. Department of Medicine, Bangalore Medical College and Research Institute, Bangalore, Karnataka, India
  • Akhila Rao K. Department of Medicine, Bangalore Medical College and Research Institute, Bangalore, Karnataka, India
  • Umesh K. J. Department of Medicine, Bangalore Medical College and Research Institute, Bangalore, Karnataka, India
  • Prashant B. C. Department of Medicine, Bangalore Medical College and Research Institute, Bangalore, Karnataka, India

DOI:

https://doi.org/10.18203/2349-3933.ijam20182391

Keywords:

AIMS65, ALBI, Clinical Rockall score, Glasgow Blatchford, Non-endoscopic scoring systems, PALBI, Upper GI bleed

Abstract

Background: Several scoring systems have been designed for risk stratification and prediction of outcomes in upper GI bleed. Endoscopy plays a major role in the diagnostic and therapeutic management of UGIB patients. However not all patients with UGIB need endoscopy. The objective of the present study was compared the prediction of mortality using different scoring systems in patients with upper GI bleed. A decision tool with a high sensitivity would be able to identify high and low risk patients and for judicious utilization of available resources.

Methods: 100 patients were assessed with respect to their clinical parameters, organ dysfunction, pertinent laboratory parameters and five risk assessment scores i.e. clinical Rockall, Glasgow Blatchford, ALBI, PALBI and AIMS65 were calculated.

Results: For prediction of outcomes, AIMS65 was superior to the others (AUROC of 0.889), followed by the GBS (AUROC of 0.869), followed by clinical Rockall score (AUROC 0.815), followed by ALBI score (AUROC of 0.765), followed by PALBI score (AUROC of 0.714) all values being statistically significant.

Conclusions: The AIMS65 score is best in predicting the mortality in patients with upper GI bleed. The optimum cut off being >2. Though GBS may be better in predicting the need for intervention, it is inferior in predicting the mortality. The newer scores like ALBI and PALBI are inferior to AIMS65 and GBS in predicting mortality.

References

Bashir S, Roy P. Upper Gastrointestinal Bleeding – A Review of the Literature (Part 1). Indian J Pract Doc. 2005;5(2):2008-05, 2008-06.

Ramaekers R, Mukarram M, Smith CA, Thiruganasambandamoorthy V. The Predictive Value of Preendoscopic Risk Scores to Predict Adverse Outcomes in Emergency Department Patients with Upper Gastrointestinal Bleeding: A Systematic Review. Acad Emerg Med. 2016;23(11):1218-27.

D.L.Kasper, A.S.Fauci, S.L.Hauser, D.L.Longo, J.L.Jameson, J.Loscalzo. Harrison’s principles of internal medicine. 19th ed. New York: McGrawHill; 2015.

Al-Assi NM, Genta RM, Karttunen TJ, Graham DY. Ulcer site and complications: relation to Helicobacter pylori infection and NSAID use. Endoscopy. 1996;28(02):229-33.

Fallah MA, Prakash C, Edmundowicz S. Acute gastrointestinal bleeding. Med Clin North Am. 2000;84(5):1183-208

Rockall TA, Logan RF, Devlin HB, Northfield TC.Risk assessment after acute upper gastrointestinal haemorrhage. Gut. 1996;38(3):316-21.

Blatchford O, Murray WR, Blatchford M. A risk score to predict need for treatment for upper gastrointestinal haemorrhage. Lancet. 2000;356(9238):1318-21.

Srygley FD, Gerardo CJ, Tran T, Fisher DA. Does this patient have a severe upper gastrointestinal bleed?. J Am Med Assoc. 2012;307(10):1072-9.

Johnson PJ, Berhane S, Kagebayashi C, Satomura S, Teng M, Reeves HL, O'Beirne J, Fox R, Skowronska A, Palmer D, Yeo W. Assessment of liver function in patients with hepatocellular carcinoma: a new evidence-based approach: the ALBI grade. J Clin Oncol. 2015;33(6):550.

Saltzman JR, Tabak YP, Hyett BH, Sun X, Travis AC, Johannes RS. A simple risk score accurately predicts in-hospital mortality, length of stay, and cost in acute upper GI bleeding. Gastrointestinal Endosc. 2011;74(6):1215-24.

Hyett BH, Abougergi MS, Charpentier JP, Kumar NL, Brozovic S, Claggett BL, Travis AC, Saltzman JR. The AIMS65 score compared with the Glasgow-Blatchford score in predicting outcomes in upper GI bleeding. Gastrointest Endosc. 2013;77(4):551-7.

Barkun AN, Bardou M, Kuipers EJ, Sung J, Hunt RH, Martel M, Sinclair P. International consensus recommendations on the management of patients with nonvariceal upper gastrointestinal bleeding. Ann Intern Med. 2010;152(2):101-13.

Acute Upper Gastrointestinal Bleeding: Evidence Update August 2015. Manchester: National Institute for Health and Clinical Excellence, 2014.

DeLong ER, DeLong DM, Clarke-Pearson DL. Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. Biometrics. 1988;837-45

Tham TC, James C, Kelly M. Predicting outcome of acute non-variceal upper gastrointestinal haemorrhage without endoscopy using the clinical Rockall Score. Postgraduate Med J. 2006;82(973):757-9.

Phang TS, Vornik V, Stubbs R. Risk assessment in upper gastrointestinal haemorrhage: implications for resource utilisation. N Z Med J. 2000; 113(1115):331.

Wang CH, Chen YW, Young YR, Yang CJ, Chen IC. A prospective comparison of 3 scoring systems in upper gastrointestinal bleeding. Am J Emerg Med. 2013;31(5):775-8.

Köksal Ö1, Özeren G, Özdemır F, Armağan E, Aydin Ş, Ayyildiz T. Prospective validation of the Glasgow Blatchford scoring system in patients with upper gastrointestinal bleeding in the emergency department. Turk J Gastroenterol. 2012;23(5):448-55.

Stanley AJ, Dalton HR, Blatchford O, Ashley D, Mowat C, Cahill A et al. Multicentre comparison of the Glasgow Blatchford and Rockall Scores in the prediction of clinical end-points after upper gastrointestinal haemorrhage. Aliment Pharmacol Ther. 2011;34:470-5.

Pang SH, Ching JY, Lau JY, Sung JJ, Graham DY, Chan FK. Comparing the Blatchford and pre-endoscopic Rockall score in predicting the need for endoscopic therapy in patients with upper GI hemorrhage. Gastrointest Endosc. 2010;71(7):1134-40.

Aquarius M, Smeets FG, Konijn HW, Stassen PM, Keulen ET, Van Deursen CT et al. Prospective multicenter validation of the Glasgow Blatchford bleeding score in the management of patients with upper gastrointestinal hemorrhage presenting at an emergency department. Eur J Gastroenterol Hepatol. 2015;27(9):1011-6.

Saltzman JR, Tabak YP, Hyett BH, Sun X, Travis AC, Johannes RS. A simple risk score accurately predicts in-hospital mortality, length of stay, and cost in acute upper GI bleeding. Gastrointestinal endoscopy. 2011;74(6):1215-24.

Stanley AJ, Laine L, Dalton HR, Ngu JH, Schultz M, Abazi R et al. Comparison of risk scoring systems for patients presenting with upper gastrointestinal bleeding: international multicentre prospective study. BMJ. 2017;356:i6432.

Yaka E, Yılmaz S, Özgür Doğan N, Pekdemir M. Comparison of the Glasgow‐Blatchford and AIMS65 scoring systems for risk stratification in upper gastrointestinal bleeding in the emergency department. Acad Emerg Med. 2015;22(1):22-30.

Elshaarawy O, Samea EA, Gomaa A, Allam N, Saad M, Waked I. PALBI-the platelet-albumin-bilirubin score: a better predictor of outcome of acute variceal bleeding. J Hepatol. 2017;66(1):S564.

Downloads

Published

2018-07-23

Issue

Section

Original Research Articles