DOI: http://dx.doi.org/10.18203/2349-3933.ijam20183132

Comparative study of lipid profile between clinical and subclinical hypothyroidism

Tumbanatham A., Jayasingh K., Varun Vijayan Vijayan

Abstract


Background: Subclinical hypothyroidism (SH) is characterized by elevated levels of serum thyroid stimulating hormone in the presence of normal thyroxin levels. Subclinical hypothyroidism is often associated with elevated total cholesterol and other lipid profile parameters. This study was done to evaluate the lipid metabolism in subclinical hypothyroidism.

Methods: This case control study was done to compare the lipid profile parameters between subclinical and overt hypothyroidism cases attending the outpatient facility of our tertiary care hospital of our medical college in Puducherry. Newly diagnosed cases of hypothyroidism were selected by convenient sampling. A total of 37 SH cases and 31 overt hypothyroidism cases were included. Blood samples were drawn to measure lipid profile. A 2D echocardiogram was done to evaluate cardiac function. Ultrasonogram was done to evaluate fatty liver.

Results: The mean age of the participants in the subclinical hypothyroidism group was 34.2±12.2 years while in the clinical hypothyroidism group was 35.7±9.8 years. About 13.5% of the participants in subclinical hypothyroidism group and 12.9% of the participants in clinical hypothyroidism had fatty liver in ultrasound. A significant difference was observed in the mean values of total cholesterol, triglycerides and LDL levels between clinical and subclinical hypothyroidism.

Conclusions: This study highlights the need for screening of subclinical hypothyroidism in order to prevent the incidences of cardiovascular complications and other diseases like metabolic syndrome.


Keywords


Hypothyroidism, L- Thyroxin therapy, Metabolic syndrome, Subclinical hypothyroidism, Thyroid stimulating hormone

Full Text:

PDF

References


Unnikrishnan AG, Kalra S, Sahay RK, Bantwal G, John M, Tewari N. Prevalence of hypothyroidism in adults: An epidemiological study in eight cities of India. Indian J Endocrinol Metabolism. 2013;17(4):647.

Ayala AR, Danese MD, Ladenson PW. When to treat mild hypothyroidism. Endocrinol Metab Clin North Am. 2000;29(2):399-4.

Kumar H, Singh VB, Meena BL, Gaur S, Singla R, Sisodiya MS. Clinical profile of thyroid dysfunction in elderly: an overview. Thyroid Res Practice. 2016;13(3):101.

Efstathiadou Z, Bitsis S, Milionis HJ, Kukuvitis A, Bairaktari ET, Elisaf MS, Tsatsoulis A. Lipid profile in subclinical hypothyroidism: is L-thyroxine substitution beneficial?. Eur J Endocrinol. 2001;145(6):705-10.

Deshmukh V, Behl A, Iyer V, Joshi H, Dholye JP, Varthakavi PK. Prevalence, clinical and biochemical profile of subclinical hypothyroidism in normal population in Mumbai. Indian J Endocrinol Metabolism. 2013;17(3):454.

Fatourechi V. Subclinical hypothyroidism: an update for primary care physicians. In Mayo Clinic Proceed. Elsevier. 2009;84(1):65-71.

Aksoy DY, Cinar N, Harmanci A, Karakaya J, Yildiz BO, Usman A, et al. Serum resistin and high sensitive CRP levels in patients with subclinical hypothyroidism before and after L-thyroxine therapy. Medical Sci Monitor: Inte Med J Experimen Clin Res. 2013;19:210.

Raza SA, Mahmood N. Subclinical hypothyroidism: controversies to consensus. Indian J Endocrinol Metab. 2013;17(Suppl 3):S636.

Liu XL, He S, Zhang SF, Wang J, Sun XF, Gong CM, et al. Alteration of lipid profile in subclinical hypothyroidism: a meta-analysis. Medical Sci Monitor: Int Med J Experimen Clin Res. 2014;20:1432.

Canaris GJ, Manowitz NR, Mayor G, Ridgway EC. The Colorado Thyroid disease prevalence study. Arch Intern Med. 2000;160(4):526-34.

Maleki N, Kazerouni F, Hedayati M, Rahimipour A, Parham M. Subclinical hypothyroidism and the alterations of lipid profile as a cardiovascular risk factor. J Paramed Sci. 2015;6(4):20-5.

Posadas-Romero C, Jorge-Galarza E, Posadas Sanchez R, Acuna-Valerio J, Juarez-Rojas JG, Kimura-Hayama E et al. Fatty liver largely explains associations of subclinical hypothyroidism with insulin resistance, metabolic syndrome, and subclinical coronary atherosclerosis. Eur J Endocrinol. 2014;171(3):319-25.

Lee KW, Bang KB, Rhee EJ, Kwon HJ, Lee MY, Cho YK. Impact of hypothyroidism on the development of non-alcoholic fatty liver disease: A 4-year retrospective cohort study. Clin Molecular Hepatol. 2015;21(4):372-8.

Lin SY, Wang YY, Liu PH, Lai WA, Sheu WH. Lower serum free thyroxine levels are associated with metabolic syndrome in a Chinese population. Metabolism. 2005;54(11):1524-8.