Published: 2018-07-23

Prevalence and risk factors of acid peptic ulcer disease at a tertiary care hospital

Manohar Shankarrao Chavan, M. Bhaktavatsalam


Background: In day to day practice, at outpatient department of General Medicine, at Mahavir Institute of Medical Sciences, Vikarabad, Telangana, India authors are coming across a significant number of patients with acid peptic disease (APD). This prompted us to carry out the present study. The objective is to study the prevalence, risk factors of acid peptic disease and to give suitable recommendations

Methods: Present study was hospital based cross sectional study carried out at outpatient department of General Medicine for a period of ten months from June 2017 to March 2018 among 307 outpatients.

Results: The prevalence of acid peptic disease was found to be very high in the present study i.e. 38.1%. This was very high compared to the available literature. The prevalence of acid peptic disease was significantly associated with increasing age, lower social class, alcohol use, tea use and NSAID use. Acid peptic disease was not found to be associated with sex, residence, literacy, smoking, coffee intake, and obesity.

Conclusions: Prevalence of acid peptic disease was found to be very high in the present study. Hence there is a need to institute the preventive and control measures to bring down the prevalence. At the same time the people in the surroundings should be made aware of this health problems and its risk factors.


Acid peptic disease, Prevalence, Risk factors

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Chan FK, Leung WK. Peptic-ulcer disease. Lancet. 2002;360:933-41.

Sonnenberg A, Everhart JE. The prevalence of self-reported peptic ulcer in the United States. Am J Public Health. 1996;86:200-5.

Xia B, Xia HH, Ma CW, Wong KW, Fung FM, Hui CK, et al. Trends in the prevalence of peptic ulcer disease and Helicobacter pylori infection in family physician-referred uninvestigated dyspeptic patients in Hong Kong. Aliment Pharmacol Ther. 2005;22:243-9.

McColl KE, Fullarton GM. Duodenal ulcer pain--the role of acid and inflammation. Gut. 1993;34:1300-2.

Kang JY, Yap I, Guan R, Tay HH. Acid perfusion of duodenal ulcer craters and ulcer pain: a controlled double blind study. Gut. 1986;27:942-5.

Lu CL, Chang SS, Wang SS, Chang FY, Lee SD. Silent peptic ulcer disease: frequency, factors leading to "silence," and implications regarding the pathogenesis of visceral symptoms. Gastrointest Endosc. 2004;60:34-8.

Jorde R, Burhol PG. Asymptomatic peptic ulcer disease. Scand J Gastroenterol. 1987;22:129-34.

Charan J, Biswas T. How to calculate sample size for different study designs in medical research?. Indian J Psychol Med. 2013;35:121-6.

Wang FW, Tu MS, Mar GY, Chuang HY, Yu HC, Cheng LC, et al. Prevalence and risk factors of asymptomatic peptic ulcer disease in Taiwan. World J Gastroenterol. 2011;17(9): 1199-203.

Levenstein S, Kaplan GA. Socioeconomic status and ulcer. A prospective study of contributory risk factors. J Clin Gastroenterol. 1998;26(1):14-7.

Everhart JE, Byrd-Holt D, Sonnenberg A. Incidence and risk factors for self-reported peptic ulcer disease in the United States. Am J Epidemiol. 1998;147(6):529-36.

Talamini G, Tommasi M, Amadei V, Pajusco B, Pajusco B, Fratucello A et al. Risk factors of peptic ulcer in 4943 inpatients. J Clin Gastroenterol. 2008;42(4):373-80.

Stack WA, Atherton JC, Hawkey GM, Logan RF, Hawkey CJ. Interactions between Helicobacter pylori and other risk factors for peptic ulcer bleeding. Aliment Pharmacol Ther. 2002;16(3):497-506.

Rosenstock S, Jorgensen T, Bonnevie O, Andersen L. Risk factors for peptic ulcer disease: a population based prospective cohort study comprising 2416 Danish adults. Gut. 2003;52(2):186-93.