Published: 2018-07-23

Thyroid dysfunction in patients with diabetes mellitus at Puducherry, India: a retrospective study

K. Shaik Anwar Hussain


Background: There is a complex interrelationship in the co-existence of thyroid dysfunction among diabetic patients and may be related to the development of cardiovascular diseases and other complications of long term metabolic derangements. The prevalence of thyroid dysfunction varies from 10 to 24% among diabetic patients. The objective of the present study was to determine the prevalence of thyroid dysfunction among the patients with diabetes mellitus in a tertiary care hospital at Puducherry, India.

Methods: This retrospective study was conducted during June 2018 analysing the records of diabetes patients attending to the diabetes OPD, Department of General Medicine in the past one year and their association with thyroid dysfunction was studied.

Results: Among the study participants (n=200), 14.5% (n=29) were Type I diabetics and 85.5% (n=171) were type II Diabetes patients. The prevalence of Thyroid Dysfunction (TD) among the study participants was 28.5% (n=57). The proportion of TD was higher among type 1 DM compared to type 2 (p<0.001).  The prevalence of subclinical hypothyroidism was more (n=7, 24.1%) among type 1DM compared to type II DM patients (p=0.05).

Conclusions: There was a higher prevalence of TD among the diabetics. TD was more frequent among type 1 DM compared to Type 2 DM patients and the most frequent TD associated with diabetes was subclinical hypothyroidism.


Diabetes mellitus, Prevalence, Thyroid dysfunction

Full Text:



Hage M, Zantout MSM, Azar ST. Thyroid disorders and diabetes mellitus. J Thyroid Res. 2011;2011:439-63.

Silva RD. Importance of evaluation of thyroid function in patients with diabetes mellitus. Arq Bras Endocrinol Metab. 2005; 49(2):180-82.

Umpierrez GE, Latif KA, Murphy MB, Lambert HC, Stentz F, Bush A, et al. Thyroid dysfunction in patients with type 1 diabetes- a longitudinal study. Diabetes Care. 2003;26(4):1181-85.

Gharib H, Tuttle RM, Baskim J, Fish LH, Singer PA, McDermott MT. Consensus statement. Subclinical thyroid dysfunction: a joint statement on management from the American association of clinical endocrinologists, the American thyroid association and the endocrine society. J Clin Endocrinol Metab. 2005;90(1):581-5.

Chen G, Wu J, Lin Y, Huang B, Yao J, Jiang Q, et al. Associations between cardiovascular risk, insulin resistence, β- cell function and thyroid dysfunction- a cross-sectional study in She ethnic minority group of Fujian Province in China. Euro J Endocrinol. 2010;163(5):775-82.

Palma CC, Pavesi M, Nogueira VG, Clemente EL, Pereira MD, Pereira LC, et al. Prevalence of thyroid dysfunction in patients with diabetes mellitus. Diabetol Metab Syndr. 2013;5(1):58.

Ramos AJ, Costa AD, Benicio AV, Ramos AL, Silva CR, Carvalho CR et al. Prevalence of thyroid disease in patients with type 1 diabetes. Arq Bras Endocrinol Metab. 2003, 47(2):177-82.

Souza OLR, Diehl LA, Carleto LD Jr, Garcia V, Carrilho AJF, Oliveira ML et al. Prevalence of thyroid autoimmunity in a group of patients with type 1 diabetes mellitus in Londrina, PR. Arq Bras Endocrinol Metab 2005;49(2):228-33.