DOI: http://dx.doi.org/10.18203/2349-3933.ijam20182463

Serum lipid profile and serum magnesium levels in newly diagnosed type 2 diabetic subjects and normal individuals: a case control study

K. Shaik Anwar Hussain

Abstract


Background: Hypomagnesaemia may be considered as one of the aggravating factors for insulin resistance. The kidneys lose their ability to maintain magnesium levels during periods of uncontrolled hyperglycaemia which may then result in lower blood levels of magnesium. Lipid profile and magnesium show significant variability in diabetes. The objective of the present study was to compare serum magnesium levels, lipid profile and HbA1c levels among patients newly diagnosed with type 2 diabetes mellitus and normoglycemic individuals.

Methods: The study was conducted during 60 patients (30 cases and 30 controls) attending to the diabetes clinic. Cases were 30 newly detected T2DM subjects, proved normotensives, not initiated on any oral- hypoglycaemic, anti-hypertensive or lipid lowering drugs, aged between 20 to 30 years. Controls were similar age and gender matched non-diabetics. The biochemical parameters like Mg levels, HbA1c and lipid profile were compared between cases and controls.

Results: The serum magnesium and HDL-C levels were significantly (p<0.001) lower among the diabetics compared to the healthy subjects. TG, total cholesterol, LDL-C showed significantly (p<0.001) higher mean levels in diabetics compared to the controls.

Conclusions: Serum magnesium levels and lipid profile were significantly different in diabetic patients compared to normal individuals.


Keywords


Lipid profile, Serum magnesium, Type 2 diabetes

Full Text:

PDF

References


Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care. 2004;27(5):1047-53.

Chehade JM, Gladysz M, Mooradian AD. Dyslipidemia in type 2 diabetes: prevalence, pathophysiology, and management. Drugs. 2013;73(4):327-39.

Institute of Medicine. Food and Nutrition Board. Dietary reference intakes: Calcium, phosphorus, magnesium, vitamin D and fluoride. National Academy Press. Washington DC, 1999.

Hua H, Gonzales J, Rude RK. Magnesium transport induced ex vivo by a pharmacological dose of insulin is impaired in non-insulin-dependent diabetes mellitus. Magnes Res. 1995;8(4):359-66.

Karim R, Nargis W, Begum KA, Subhan SS, Uddin MN. Serum lipid profile, serum magnesium and fasting serum glucose in newly diagnosed type 2 diabetic subjects. Bangladesh J Med Biochem 2014; 7(1):4-8.

Sendhav SS, Kakaiya A, Chatterjee B. Evaluation of serum magnesium level along with lipid profile in a Gujarati Population diagnosed with Diabetes Mellitus. Indian J Med Biochem 2017;21(2):112-6.

Nasri H. Lipids in association with serum magnesium in diabetes mellitus patients. Acta Angiol. 2006;12(4):149-54.

Streter DHP, Gerstein MM, Marmor BM, Doisy RJ Reduced glucose tolerance in elderly human subjects. Diabetes. 2012;14:579-83.

American Diabetes Association (1992) Magnesium supplementation in the treatment of diabetes. Diabetes Care.1992;15(8):1065-67.

Ewald U, Gebre-Medhin M, Tuvemo T. Hypomagnesemia in diabetic children. Acta Padediatr Scand. 2013;72:367-71.