Published: 2018-07-23

Incidence of iron deficiency anaemia and it’s early detection in patients with hypoproliferative anaemia presentation in a tertiary care hospital

Vishnu Anjan Nareddy, M. Sai Varun, Nagabushana M.V.


Background: Iron deficiency anaemia still remains the most common cause of anaemia not only in India but also world over. According to world heath report, there are 1,788,600 people in this world suffering from Iron deficiency anaemia. Iron deficiency anaemia is foremost prevalent disease-causing morbidity in world and therefore it is always absolutely necessary to detect this particular condition in early stages before the eventual development of various dreadful complications like Heart failure and Myocardial infarction. The aim of the study is to find incidence of iron deficiency anaemia in patients with hypo proliferative anaemia presentation, with a possible iron deficient state, by analyzing the haematological and biochemical parameters.

Methods: The study was conducted from November 2017 to May 2018 for a period of 6 months which included 50 subjects from both sex groups, aged 20-80 years with the diagnosis of hypo proliferative anaemia.

Results: The study results indicate that females (60%) were significantly overrepresented compared to males (40%). Of the 50 subjects 38% were in stage of negative iron balance (stage1) and 32% were in stage of iron deficient erythropoiesis(stage2) and 30% were in normal stage.

Conclusions: This Observational study showed a majority of patients with hypo-proliferative anaemia presenting at early stages of negative iron balance and iron deficient erythropoiesis thereby indicating the importance of initiating iron therapy at an early stage even without correlative iron studies.


Hypo-proliferative anaemia, Iron deficient erythropoiesis, Negative iron balance, Serum ferritin, Serum iron, Total iron binding capacity

Full Text:



Khusun H, Yip R, Schultink W, Dillon DH. World Health Organization hemoglobin cut-off points for the detection of anemia are valid for an Indonesian population. J Nutr. 1999;129(9):1669-74.

Peyrin-Biroulet L, Williet N, Cacoub P. Guidelines on the diagnosis and treatment of iron deficiency across indications: a systematic review. Am J Clin Nutr. 2015;102(6):1585-94.

Looker AC, Dallman PR, Carroll MD, Gunter EW, Johnson CL. Prevalence of iron deficiency in the United States. J Am Med Assoc Int Edition. 1997;277(12):973-6.

Karp RJ, Haaz WS, Starko K, Gorman JM. Iron deficiency anaemia in families of iron deficient inner-city school children. Am J Dis child. 1974;128:18-20.

Bothwell TH. The diagnosis of iron deficiency. N Z Med J. 1966;65:880-3.

Heinrich HC. Iron deficiency without anaemia. Lancet. 1968;2(7565):460.

Assessing the iron status of populations: report of a joint World Health Organization/Centres for Disease Control and Prevention technical consultation on the assessment of iron status at the population level, 2nd ed., Geneva, World Health Organization, 2007. Available at

Babaei M, Shafiei S, Bijani A, Heidari B, Hosseyni SR, Vakili Sadeghi M. Ability of serum ferritin to diagnose iron deficiency anemia in an elderly cohort. Revista Brasileira de Hematologia E Hemoterapia. 2017;39(3):223-8.

Soldin OP, Bierbower LH, Choi JJ, Choi JJ, Thompson-Hoffman S, Soldin SJ. Serum iron, ferritin, transferrin, total iron binding capacity, hs-CRP, LDL cholesterol and magnesium in children; new reference intervals using the Dade Dimension Clinical Chemistry System. Clinica Chimica Acta. 2004;342(1-2):211-7.

Dopsaj V, Martinovic J, Dopsaj M. Early detection of iron deficiency in elite athletes: could microcytic anemia factor (Maf) be useful?. Int J Lab Hematol. 2014;36(1):37-44.

Hotez PJ, Brooker S, Bethony JM, Bottazzi ME, Loukas A, Xiao S. Hookworm infection. New England Journal of Medicine. 2004;351(8):799-807.

Vander Weyden MB, Fong H, Hallam LJ, Breidahl MJ. Basic ferritin content of red cells of patients with anemia and polycythemia Vera. Pathology. 1984;16(4):419-23.