DOI: http://dx.doi.org/10.18203/2349-3933.ijam20183148

Association of BMI with markers of angiogenesis in healthy population

Shivani Jaswal, Harjeet Kaur, Jasbinder Kaur, Seema Gupta

Abstract


Background: Obesity is associated with an increased risk of atherosclerosis, which can be mediated by an increase in angiogenesis and inflammation. The objective of the present study was to explore the relationship between BMI and levels of VEGF, a circulating biomarker of angiogenesis.

Methods: 225 healthy volunteers in the age group of >18 years formed the subjects of the study. Individuals with any acute or chronic illness including history of HT, DM, and smoking, alcohol or drug abuse or on any long term medication were excluded from the study. Anthropometric measurements were taken, and BMI calculated. Blood samples were taken, and serum levels of VEGF were estimated using commercially available ELISA kits. Student’s ‘t’ test was done for comparison and correlation was assessed using Pearson’s method.

Results: A statistically significant difference in the levels of VEGF was found in subjects with BMI < 25 kg/m2 as compared to subjects with BMI > 25 kg/m2 (p<0.001). A significant positive correlation was found between the levels of VEGF and BMI in both males and female subjects of the study group (r=0.68 and 0.73 respectively).

Conclusions: The positive correlation of levels of VEGF with BMI in the healthy subjects of the study group may be related to the expansion of adipose tissue and to the concomitant formation of new vessels to support tissue deposition. These factors may predispose an individual to an increased risk of atherosclerotic damage later in life. VEGF may therefore, have a potential as a biomarker for the prediction of cardiovascular risk and estimation may allow intervening with lifestyle modifications and nutritional changes before the disease is manifested and pharmacotherapy is required.


Keywords


BMI, Cardiovascular risk, Obesity, VEGF

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References


WHO: Global Health Observatory data. Available at www.who.int/gho/ncd/risk_factors/overweight/en/ accessed on 06.06.18

WHO; 2012.World Health Organization (WHO). World Health Statistics 2012. Available at http://www.who.int/gho/publications/world_health_statistics/EN_WHS2012_Full.pdf Accessed on 06.06.18

Pradeepa R, Anjana RM, Joshi SR, Bhansali A, Deepa M, Joshi PP, et al. Prevalence of generalized and abdominal obesity in urban and rural India. IJMR. 2015;142(2):139-50.

Gregg EW, Cheng YJ, Cadwell BL, Imperatore G, Williams DE, Flegal KM et al. Secular trends in cardiovascular disease risk factors according to body mass index in US adults. JAMA. 2005;293(15):1868-74.

Snell-Bergeon JK, Hokanson JE, Kinney GL, Dabelea D, Ehrlich J, Eckel RH, et al. Measurement of abdominal fat by CT compared to waist circumference and BMI in explaining the presence of coronary calcium. Int J Obes Relat Metab Disord. 2004;28(12):1594-9.

Khurana R, Simons M, Martin JF, Zachary IC. Role of angiogenesis in cardiovascular disease. A critical appraisal. Circulation. 2005;112:1813-24.

Loebig M, Klement J, Schmoller A, Betz S, Heuck N, Schweiger U, et al. Evidence for a relationship between VEGF and BMI independent of insulin sensitivity by glucose clamp procedure in a homogenous group healthy young men. Plos One. 2010;5(9):e12610.

WHO expert consultation. Appropriate body mass index for asian population and its implications for policy and intervention strategies. Lancet. 2004;363:157-63.

Yusuf S, Hawken S, Ounpuu S, Bautista L, Franzosi MG, Commerford P et al. Obesity and the risk of myocardial infarction in 27,000 participants from 52 countries: a case-control study. Lancet. 2005 Nov; 366(9497):1640-9.

Gungor N, Thompson T, Sutton-Tyrrell K, Janosky J, Arslanian S. Early signs of cardiovascular disease in youth with obesity and type 2 diabetes. Diabetes Care. 2005 May;28(5):1219-21.

Valavanis IK, Mougiakakou SG, Grimaldi KA, Nikita KS. A multifactorial analysis of obesity as CVD risk factor: use of neural network based methods in a nutrigenetics context. BMC Bioinformatics. 2010 Dec;11(1):453.

Akil L, Ahmad HA. Relationships between obesity and cardiovascular diseases in four Southern States and Colorado. J Health Care Poor Underserved. 2011;22(4 Suppl):61-72.

Silha JV, Kersek M, Sucharda P, Murphy LJ. Angiogenic factors are elevated in overweight and obese individuals. Int J Obesity. 2005;29:1308-14.

Hausman GJ, Richardson RL. Adipose tissue angiogenesis. J Anim Sci. 2004;82:925-34.

Liu L, Meydani M. Angiogenesis inhibitors may regulate adiposity. Nutr Rev. 2003;61:384-7.

Chou E, Suzuma I, Way KJ, Opland D, Clermont AC, Naruse K et al. Decreased cardiac expression of vascular endothelial growth factor and its receptors in insulin-resistant and diabetic states: a possible explanation for impaired collateral formation in cardiac tissue. Circulation. 2002;105:373-9.

Stacker SA, Achen MG. the vascular endothelial growth factor family: signaling for vascular development. Growth Factors. 1999;17:1-11.

Keck RG, Berleau L, Harris R, Keyt BA. Disulfide structure of the heparin binding domain in vascular endothelial growth factor: characterization of posttranslational modifications in VEGF. Arch Biochem Biophys. 1997;344:103-13.

Miyazawa-Hoshimoto S, Takahashi K, Bujo H, Hashimoto N, Saito Y. Elevated serum vascular endothelial growth factor is associated with visceral fat accumulation in human obese subjects. Diabetologia. 2003;46:1483-8.