Study of pulmonary functions with DLco in acute respiratory distress syndrome/ acute lung injury syndrome

Praveen Chabukswar, Jaya Baviskar


Background: The objective of this is to study the lung functions with DLco in ARDS/ALI survivors; to study and analyse the lung functions in different diseases causing ARDS/ ALI survivors and to analyse the effect of treatment strategies on lung functions with DLco in survivors.

Methods: All patients who survived ARDS/ALI illness from January 2008 to July 2009 are selected and follow up for pulmonary function at discharge, 3 months and 6 months were performed post illness were recorded and compared.

Results: In the study period, 37 cases were enrolled in the prospective cohort study, out of which 9(24.3%) were suffering from ALI according to American European Consensus definition. There was varied infections etiology causing ARDS/ ALI. Pulmonary function test at discharge were showing normal flow rates and volumes (94.6%), mild restriction in some cases (8.4%) as the patients included in the study does not have any past respiratory illness out of 37(100%) patients of ARDS/ALI discharged from Hospital 21(56.8%) had low DLco and 16 (43.2%) had normal DLco.

Conclusions: Diffusion defect is found to be more common in the patients who had mixed infections than the patients who had single infection. There was no effect of steroids on the outcome of the patients in terms of diffusion defect.


Acute Respiratory Distress Syndrome (ARDS), Acute Lung Injury (ALI), Pulmonary Function Test (PFT)

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Atabai K, Matthay MA. Acute lung injury and acure respiratory distress syndrome: definitions andepidemiology. Thorax. 2002:57:452-8.

Ashbaugh DG, Bigelow DB, Petty TL, Levine BE. Acute respiratory distress in adults. Lancet. 1967;2:319-23.

Murray JF, Matthay MA, Luce JM. An expanded definition of the adult respiratory distress syndrome. Am Rev Respair Dis. 1988;138:720-3:erratum 1989;139:1065.

Doyle RL, Szaflarski N, Modin GW, Weiner- Kronish MA. Identification of patients with acute lung injury, predictors of mortality. Am J Respair Crit Care Med. 1995;152:1818-24.

Zilberberg MD, Epstein SK. Acute lung injury in the medical ICU; co- morbid conditions, age, etiology and hospital outcome. Am J Respair Crit Care Med. 1998;157: 1159-64.

Bernald GR, Artigas A, Brigham KL. The American –European consensus conference on ARDS. definitions, mechanisms, relevant outcomes and clinical trial coordination. Am J Respair Crit Care Med. 1994;149:818-24.

National Heart and Lung Institute. Task force on problems, research approaches, needs: the lung program. Washington, DC: Department of Health, Education and Welfare. 1972:165-80.

Luhr OR, Antonsen K, Karlsson M. Incidence and mortality after acute respiratory failure and acute respiratory distress syndrome in Sweden, Denmark and Iceland. The ARF Study group. Am J Respair Crit Care Med. 1999;159:1849-61.

Lewendowski K, Metz J, Deutschmann C. Incidence, severity and mortality of acute respiratory failure in Berlin, Germany. Am J Respair Crit CARE Med. 1995;151:1121-25.

Thomsen GE, Morris AH. Incidence of Adult respiratory distress syndrome in the state of Utah. Am J Respair Crit Care. 1995;152:965-71.

Villar J. Slutsky AS. The incidence of the adult respiratory distress syndrome. Am Rev Respair Dis. 1989;140:814-16.

Webster NR, Cohen AT, Nunn JF. Adult respiratory distress syndrome: how many cases in the UK?. Anaesthesia. 1988;43:923-6.

Vigg A, Mantri S. Clinical profile of ARDS. JAPI. 2003;51:855-58.

Bernald GR, Artigas A, Bringham KL. The American - European consensus conference on ARDS. definitions, mechanisms, relevant outcomes and clinical trial coordination. Am J RespirCrit Care Med. 1994;149:818-24.

Knaus WA, Draper EA, Wagner DP, Zimmerman JE. APACHE II: a severity of disease classification system. Critical Care Med. 1985 Oct 1;13(10):818-29.

Sloane PJ, Gee MH, Gottlieb JE. A multicenter registry of patients with acute respiratory distress syndrome. Physiology and Outcome. Am Rev Respair Dis. 1992;146:419-26.

Vicent JL, Moreno R, Takala J, Willats S, De Mendonca A. The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. Intensive Care Med. 1996;22(5):707-10.

Herridge MS, Cheung AM, Tansey CM, Matte-Martyn A, Diaz-Granados N, Al-Saidi F et al. One-year outcomes in survivors of the acute respiratory distress syndrome. N Engl J Med. 2003;348(8):683-93.