Published: 2018-09-22

Histopathological analysis of thyroid lesions: an institutional experience

Sheela K. M., Sreedevi A. R.


Background: Diseases of thyroid are one of the most common endocrine disorders affecting general population which range from non-neoplastic to neoplastic lesions. The incidence and pattern of thyroid lesions depend on various factors which include sex, age, ethnic and geographical patterns. Majority of thyroid lesions are non-neoplastic only <5% are malignant. The aim of the present study was to determine the frequency and histomorphological pattern of thyroidectomy specimens and their relationship with age and sex of the patient.

Methods: This retrospective study was conducted in the department of pathology, Govt. Medical College, Alappuzha for a period of 2 years. The study included 620 thyroidectomy specimens received in the Department of Pathology. All the biopsy reports were reviewed, and different lesions were categorised according to age and gender distribution. The data was analysed by standard statistical methods.

Results: The commonest of the non-neoplastic lesions was nodular colloid goiter followed by lymphocytic thyroiditis, Hashimoto thyroiditis Nodular hyperplasia and thyroglossal cyst. Most common malignant lesion in this study is papillary carcinoma and benign lesion is follicular adenoma. Age group of patients ranged from 6 ½ to 84 years. The study showed a female predominance of 88.38%.

Conclusions: Thyroid disorders are commonly encountered endocrine diseases. The study showed a female predominance. Peak age of incidence of thyroid lesions was between 40 and 50 years. Most common lesion was follicular adenoma and most common malignant lesion was papillary carcinoma.

Histopathological examination is the mainstay for definite diagnosis and management of thyroid neoplasms.


Follicular adenoma, Nodular colloid goitre, Papillary carcinoma, Thyroid lesions

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Solomon R, Iliyasu Y, Mohammed AZ. Histopathological pattern of thyroid lesions in Kano, Nigeria: a 10-year retrospective review (2002-2011). Nigerian J Basic Clin Sci. 2015 Jan 1;12(1):55.

Bayliss R Thyroid disease. The fact oxford University Press. New York Toronto. 1982.

Elahi S, Manzoor-ul-Hassan A, Syed Z, Nazeer L, Nagra SA, Hyder SW. A study of goiter among female adolescents referred to centre for nuclear medicine, Lahore. Pak J Med Sci. 2005;21(1):56-62.

Burguera B, Gharib H. Thyroid incidentalomas: prevalence, diagnosis, significance, and management. Endocrinol Metabol Clin North Am. 2000 Mar 1;29(1):187-203.

Greenspan FS. The problem of the nodular goiter. Med Clin North Am. 1991 Jan;75(1):195-209.

Dash M, Chandrashekhar KP, Raghu K, Saadvi K. Histopathological study of neoplastic and non-neoplastic thyroid lesions: an institutional experience of 2 years. JEMDS. 2016 Sep 12;5(73):5348-1.

Maitra A. The Endocrine system In Kumar V, Abbas. A. K, Sausto V, Aster Je (eds) Robbins and Cotran Pathologic Basis of disease 8th Ed. Philadelphia. Elsevier Saunders. 2010; 235-249.

Tsegaye B, Ergete W. Histopathologic pattern of thyroid disease. East African Med J. 2003;80(10):525-8.

Rahman MA, Biswas MA, Siddika ST, Sikder AM, Talukder SI, Alamgir MH. Histomorphological pattern of thyroid lesions. Dinajpur Med Col J. 2013;6(2):134-40.

Hussain N, Anwar M, Nadia N, Ali Z. Pattern of surgically treated thyroid diseases in Karachi. Biomedica. 2005 Jan;21(1):18-20.

Sushel C, Khanzada TW, Zulfikar I, Samad A. Histopathological pattern of diagnoses in patients undergoing thyroid operations. Rawal Med J. 2009 Jan;34(1):14-6.

Krukowski ZH. The thyroid gland and thyroglossal tract. In Williams NS Bulstrode CJKO Connell P. K eds Connell PK eds. Baily and Loves Short practice of surgery 24th Ed. London Hodder education 2004:776-804.

Meachim G, Young MH. De Quervain's subacute granulomatous thyroiditis: histological identification and incidence. J Clin Pathol. 1963 May 1;16(3):189-99.

Thomas T, Sreedharan S, Khadilkar UN, Deviprasad D, Kamath MP, Bhojwani KM, et al. Clinical, biochemical and cytomorphologic study on Hashimoto's thyroiditis. Indian J Med Res. 2014 Dec;140(6):729.

Maitra A. The endocrine system chapter 24. In Mitchell R Kumar V, Abbas A Fausto N Aster J, Editors Robbins and Cotran Pathologic basis of disease 8th Ed. Philadelphia Saunders, Elsevier. 2011;164-165.

Kunjumon DJ, Upadhyaya K. A Clinico pathological audit of thyroid malignancies: a 2 year study. Int J Biomed Res. 2014; 5(1) 38-42.

Bharathidhasan I, Goneppanavar M, Dhaka RS. Changing trends in the incidence of thyroid lesions in coastal regions of south India. Int J Health Sci Res. 2015;5(6):134-41.

Williams ED, Abrosimov A, Bogdanova T, Demidchik EP, Ito M, LiVolsi V, et al. Morphologic characteristics of Chernobyl-related childhood papillary thyroid carcinomas are independent of radiation exposure but vary with iodine intake. Thyroid. 2008 Aug 1;18(8):847-52.