Study of reversible airway disease in patients with allergic rhinitis


  • Balabhaskar Rao Department of Pulmonary Medicine, Mediciti Hospital, Hyderabad, Telangana, India
  • Arun B. J. Department of Pulmonary Medicine, Kempegowda Institute of Medical Sciences, Bangalore, India
  • Vijay Bhaskar Department of Pulmonary Medicine, Mediciti Hospital, Hyderabad, Telangana, India
  • Niranjan Nagaraj 3rd year PG student, Department of Paediatrics, SP Medical College, Bikaner, Rajasthan, India



Allergic rhinitis, Spirometry, Sneezing, Bronchodilator, Absolute eosinophil count


Background: Allergy is a condition with wide spectrum of manifestations; it ranges from individuals with positive skin prick test without clinical features to allergic rhinitis, Atopic dermatitis, Asthma, Urticaria, Conjunctivitis, Enteritis and its most severe clinical manifestation Anaphylactic shock. This study aims to determine the baseline Spirometry in patients with allergic rhinitis using a computerized Spirometer. Assess the pulmonary function after inhalation of a bronchodilator to determine the degree of bronchodilator response. Correlate the clinical and laboratory parameters with the pulmonary functions.

Methods: This study was conducted on 50 cases of allergic rhinitis presenting to our hospital from July 2006 to December 2007. Clinical diagnosis was made after a detailed clinical history and physical examination. All the patients included in the study underwent the following investigations: Complete hemogram, Absolute eosinophil count, X ray – chest and PNS, Serum total IgE level, spirometry.

Results: Males constituted majority of population (62%) with mean age of 24±11.4 years. The most common symptom among allergic rhinitis patients was sneezing. Peripheral blood AEC levels were directly proportional to the severity of AR. Serum total IgE levels were also directly proportional to the severity of AR and severity of lower airway obstruction. PEF, FEF-25, FEF-50, FEV1% were significantly lower among AR patients with lower airway obstruction compared to patients with AR alone (p<0.05).

Conclusions: Allergic rhinitis is a common disorder among general population predominantly involving the younger age group. Multicentric prospective studies are required to evaluate further, the role of spirometry among AR patients.


Kay AB. Allergy and Allergic Diseases. First of Two Parts. N Engl J MED. 2001;344(1):30-7.

Weinberg EG. The atopic march. Current Allergy and Clinical Immunology. 2005;18(1):4-5.

Bachert C. Histamine-a major role in allergy? Clin Exp Allergy. 1998;28(6):15-9.

Jutel M, Blaser K, Akdis CA. The role of histamine in regulation of immune responses. Chem Immunol Allergy. 2006;91:174-87.

World Health Organisation – fact sheet. Indian Journal of chest diseases and allied sciences. 2000;42:126-8.

Shaik WA. Allergic rhinitis in Allergy and asthma – a clinical primer. IJCP. 1999;65.

Corren J. Allergic rhinitis and asthma: how important is the link? J Allergy Clin Immunol. 1997;99:781-6.

Chanez P, Vignola AN, Vic P. Comparison between nasal and bronchial inflammation in asthmatic and control subjects. Am J Respir Crit Care Med. 1999;159:588-95.

Seedat RY, Claassen J, Claassen AJ, Joubert G. Allergen sensitivities of patients with allergic rhinitis presenting to the ENT clinic at Universitas Academic Hospital. Current Allergy & Clinical Immunol. 2006;19(3):130-2.

Yadav SPS. A clinical profile of allergic rhinitis in Haryana, India. Indian J Allergy Asthma Immunol. 2001;15(1):13-5.






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