DOI: http://dx.doi.org/10.18203/2349-3933.ijam20183460

Correlation of microalbuminuria with neuropathy in type-II diabetes mellitus patients

P. K. Bariha, K. M. Tudu, Shiny Thomas Kujur

Abstract


Background: The microvascular and macrovascular complications in diabetes mellitus resulting in microalbuminuria and diabetic neuropathy in common in developing country like India. The aim of the study has been undertaken to emphasis upon the association of microalbuminuria with neuropathy.

Methods: The study was undertaken among 124 Type-II diabetes patients in the Department of Medicine, VIMSAR, Burla, Odisha between October 2015 to September 2017. Detail history, clinical examination, BMI, laboratory investigation like FBS, PPBS, HbA1C, nerve conduction study was done, and data were analysed and compiled.

Results: Out of 124 patients the mean age of male patients in the study was 49.75 years and that of female patients was 50.36 years. The mean age of the study population was 50.18 years. The mean BMI in patients with and without microalbuminuria was 23.95±2.04kg/m2 and 21.57±2.89kg/m2 respectively. The mean HbA1C value in patients with and without microalbuminuria was 9.96±3.380 and 8.75±3.25 respectively.

Conclusions: Microalbuminuria is significantly associated with presence of neuropathy. The most common type of neuropathy observed in this study was distal symmetrical sensory motor neuropathy. Hence, microalbuminuria has an important role as a biochemical marker for risk factor evaluation of microvascular complications in type 2 diabetes mellitus.


Keywords


BMI, Diabetes mellitus, HbA1C, Microalbuminuria, Neuropathy

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References


Keen H, Chlouverakis C. An immunoassay method for urinary albumin at low concentrations. Lancet. 1963;2:913-4.

Powers AC. Diabetes mellitus. In: Harrison’s Principles of Internal Medicine, Braunwald, Fauci, Kasper, Hauser, Longo, Jameson, editors. 17th Edn. New York: McGraw Hill. 2008;21:2-2180.

American diabetic association. Diabetic Nephropathy. Diabetes Care. 2002 Jan; 25(suppl 1): s85-s89.

Varghese A, Deepa R, Rema M, Mohan V. Prevalence of microalbuminuria in type 2 diabetes mellitus at a diabetes centre in southern India. Postgraduate Med J. 2001 Jun 1;77(908):399-402.

Afkhami-Ardekani M, Modarresi M, Amirchaghmaghi E. Prevalence of microalbuminuria and its risk factors in type 2 diabetic patients. Indian J Nephrol. 2008 Jul;18(3):112.

Thakkar B, Arora K, Vekariya R, Lulania M, Agnihotri AS. Prevalence of microalbuminuria in newly diagnosed type 2 diabetes mellitus. NJIRM. 2011;2(4):22-5.

Chavan V, Ramavataram DV, Miyani K, Lad H, Nilakhe S. Prevalence of microalbuminuria as a marker of incipient nephropathy in type 2 diabetes patients at smimer hospital, Surat. National J Comm Med. 2014:468-73.

Shonima Venugopal and Lima M Iyer. Risk factor analysis and prevalence of microalbuminuria among type 2 diabetes mellitus subjects: the need for screening and monitoring microalbumin. Asian J Exp Biol Scl. 2010;1(3) 2010:652-9.

Dadhania BP, Aravat AH, Dhruva GA. Study of microalbuminuria in diabetes type 2 patients as a marker of morbidity (a study of 100 cases in Rajkot city). Int J Biomed Adv Res. 2012;3(10):763-6.

Afkhami-Ardekani M, Modarresi M, Amirchaghmaghi E. Prevalence of microalbuminuria and its risk factors in type 2 diabetic patients. Indian J Nephrol. 2008 Jul;18(3):112.

Viswanathan V, Seena R, Lalitha S, Snehalata C, Muthu J, Ramachandran A. Significance of microalbuminuria at diagnosis of type 2 diabetes. Int J Diab Dev Countries. 1998;18.

Baghel M, Modala S, Kumar P. Correlation of creatinine clearance and urine microalbumin in type 2 diabetes mellitus. Int J Basic Appl Med Sci. 2014;4(2):182-6.

Chowta NK, Pant P, Chowta MN. Microalbuminuria in diabetes mellitus: association with age, sex, weight, and creatinine clearance. Indian J Nephrol. 2009 Apr;19(2):53.

Sheikh SA, Baig JA, Iqbal T, Kazmi T, Baig M, Husain SS. Prevalence of microalbuminuria with relation to glycemic control in type-2 diabetic patients in Karachi. J Ayub Med Coll Abbottabad. 2009 Sep 1;21(3):83-6.

Kundu D, Roy A, Mandal T, Bandyopadhyay U, Ghosh E, Ray D. Relation of microalbuminuria to glycosylated hemoglobin and duration of type 2 diabetes. Nigerian J Clin Pract. 2013;16(2):216-20.

Gupta RK, Gupta R, Maheshwari VD, Mawliya M. Impact of smoking on microalbuminuria and urinary albumin creatinine ratio in non-diabetic normotensive smokers. Indian J Nephrol. 2014 Mar;24(2):92.

Abbasi MA, Abro HA, Sheikh M. T2 Diabetes Mellitus Pak. J. Physiol. 2006; 2 (2).

Iranparvar Alamdari M, Aminisani N, Bashardoost B, Shamshirgaran S, Khodamoradzadeh M, Shokrabadi M, et al. Prevalence and risk factors of microalbuminuria in type 2 diabetic patients in a diabetic clinic of Ardabil-Iran. Int J Endocrinol Metab. 2006;4(1):8-12.

Florkowski CM, Jennings PE, Rowe B, Lawson N, Nightingale S, Barnett AH. Microalbuminuria in diabetic subjects with chronic peripheral neuropathy. Diabetes Res Clin Pract. 1988 May 19;5(1):45-8.

Al-Maskari F, El-Sadig M. Prevalence of risk factors for diabetic foot complications. BMC Family Practice. 2007;8:59.

Samatha P, Venkateswarlu M, Siva Prabodh. The role of biochemical markers in the prediction of microvascular complications in type-2 diabetes mellitus. J Clin Diag Res. 2011 November (Suppl-1), Vol-5(6): 1154-7.

Patel KL, Mhetras SB, Varthakavi PK, Merchant PC, Nihalani KD. Microalbuminuria in insulin dependent diabetes mellitus. J Assoc Physicians Indian. 1999 Jun;47(6):589-95.

Sase NS, Correia PWM Clinical profile of peripheral neuropathy - a study of 100 patient. J Assoc Phys India. 2009; 2:1-6.

Dyck PJ, Kratz KM, Karnes JL, Litchy WJ, Klein R, Pach JM, et al. The prevalence by staged severity of various types of diabetic neuropathy, retinopathy, and nephropathy in a population‐based cohort. the rochester diabetic neuropathy study. Neurol. 1993 Apr 1;43(4):817-24.

Kakrani AL, Gokhale VS, Vohra KV, Chaudhary N. Clinical and nerve conduction study correlation in patients of diabetic neuropathy. J Assoc Physicians India. 2014 Jan;62(1):24-7.