Published: 2018-11-22

Study of non-alcoholic fatty liver disease in metabolic syndrome

Mohammed Aslam Shaikh, Bhanuprakash P.


Background: Metabolic syndrome is a clustering of risk factors that increase an individual’s probability of developing atherosclerotic cardiovascular disease, type 2 diabetes mellitus and all cause mortality. Since primary NAFLD has strong association with metabolic syndrome as a whole and various components of metabolic syndrome, it is being debated whether NAFLD is a hepatic component of metabolic syndrome. Hence this study was done to study the prevalence of non-alcoholic fatty liver disease in healthy individuals and in patients with metabolic syndrome and to establish a relationship between NAFLD and Metabolic syndrome.

Methods: A total of 122 patients - 61 with metabolic syndrome and 61 without metabolic syndrome fulfilling inclusion and exclusion criteria who presented to the Medicine outpatient Department of Ramaiah Medical College, Bangalore, between October 2014 and September 2016 were included in the study. Baseline variables, laboratory parameters, ultrasound abdomen findings were compared between the groups.

Results: Mean age of the subjects in metabolic syndrome group and non-metabolic syndrome group were 52.4±15.4 and 50.7±15.4years respectively. Mean triceps skin fold thickness (in cms) for the subjects in metabolic syndrome group and non-metabolic syndrome group were 19.16±6.1 and 7.59±2.57 respectively (P <0.05). Prevalence of fatty liver on ultrasonography in metabolic syndrome and non-metabolic syndrome were 42.62 % and 21.31% respectively. Overall prevalence of NAFLD was 31.97 %.

Conclusions: Overall prevalence of NAFLD from current study was 31.97%. The prevalence of NAFLD was significantly higher in persons with metabolic syndrome than persons without metabolic syndrome.


Fatty liver, Metabolic syndrome, NAFLD

Full Text:



Neil BR, David C, Mancpren K, Jose MC. AMPK, insulin resistance, and the metabolic syndrome. J Clin Invest. 2013;123(7):2764-72.

Bellentani S, Scaglioni F, Marino M, Bedogni G. Epidemiology of non-alcoholic fatty liver disease. Digestive Dis. 2010;28(1):155-61.

Duseja A. Nonalcoholic fatty liver disease in India-a lot done, yet more required!. Indian J Gastroenterol. 2010 Nov 1;29(6):217-25.

Amarapurkar D, Kamani P, Patel N, Gupte P, Kumar P, Agal S, et al. Prevalence of non-alcoholic fatty liver disease: population based study. Ann Hepatol. 2007;6(3):161-3.

Alberti KG, Zimmet P, Shaw J. Metabolic syndrome-a new world‐wide definition. A consensus statement from the international diabetes federation. Diabetic Med. 2006 May;23(5):469-80.

Adams LA, Lymp JF, Sauver JS, Sanderson SO, Lindor KD, Feldstein A, et al. The natural history of nonalcoholic fatty liver disease: a population-based cohort study. Gastroenterol. 2005 Jul 1;129(1):113-21.

Dam-Larsen S, Franzmann M, Andersen IB, Christoffersen P, Jensen LB, Sørensen TI, et al. Long term prognosis of fatty liver: risk of chronic liver disease and death. Gut. 2004 May 1;53(5):750-5.

Hernaez R. Genetics of non-alcoholic fatty liver disease and associated metabolic disorders. Avances Diabetol. 2011 Nov 1;27(6):186-97.

Clark JM, Brancati FL, Diehl AM. Non alcoholic fatty liver disease. Gastroenterol. 2002;122:1649-57.

Donati G, Stagni B, Piscaglia F, Venturoli N, Morselli-Labate AM, Rasciti L, et al. Increased prevalence of fatty liver in arterial hypertensive patients with normal liver enzymes: role of insulin resistance. Gut. 2004 Jul 1;53(7):1020-3.

Bajaj S, Nigam P, Luthra A, Pandey RM, Kondal D, Bhatt SP, Wasir JS, Misra A. A case-control study on insulin resistance, metabolic co-variates & prediction score in non-alcoholic fatty liver disease. Indian J Med Res. 2009 Mar 1;129(3):285-92.

Uchil D, Pipalia D, Chawla M, Patel R, Maniar S, Narayani, et al. Non-alcoholic fatty liver disease (NAFLD) - the hepatic component of metabolic syndrome. J Assoc Physicians India. 2009 Mar;57:201-4.

Mishra S, Yadav D, Gupta M, Mishra H, Sharma P. Hyperinsulinemia predisposes to NAFLD. Indian J Clin Biochem. 2008 Apr;23(2):130-5.