DOI: http://dx.doi.org/10.18203/2349-3933.ijam20162525

Is vegetarian young adult male more affected by vitamin B12 deficiency anemia? A hospital based study

Shivraj Meena, Mohd. Arif, Vinod S. Jatav, Vinit Agarwal

Abstract


Background: Prevalence of B12 deficiency in the general population has not been well established because a universally accepted normal B12 level has not been defined. Aim of the study was to study vegetarian young adult male more affected by vitamin B12 deficiency anemia.

Methods: The study was conducted in 120 patients at the department of medicine, Government medical college, Kota, a tertiary care teaching hospital in Rajasthan, India.

Results: Prevalence of B12 deficiency was 19.52%, B12 deficiency in male and female were 18.33% (22) 1nd 15.83% (19) respectively. B12 deficiency in age group <20 years, 21-40 years and >41 years were 3.33%, 29.16% and 1.66% respectively.

Conclusions: Low vitamin B12 concentrations are common in Indian young adult men, particularly in vegetarians. Further studies are needed to confirm these findings in other parts of India.

 


Keywords


Vitamin B12, Vegetarian, Pancytopenia

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References


Healton EB, Savage DG, Brust JC, Garrett TJ, Lindenbaum J. Neurologic aspects of Co- balamin deficiency. Baltimore: Medicine. 1991;70:229-45.

Oh R, Brown DL. Vitamin B12 deficiency. Am Fam Physician. 2003;67(5):979-86.

Mezzano D, Kosiel K, Martinez C, Cuevas A, Panes O, Aranda E et al. Cardiovascular risk factors in vegetarians: normalization of hyper-homocysteinemia with vitamin B(12) and reduction of platelet aggregation with n-3 fatty acids. Thromb Res. 2000;100:153-60.

Herrmann W, Schorr H, Purschwitz K, Rassoul F, Richter V. Total homocysteine, vitamin B12 and total antioxidant status in vegetarians. Clin Chem. 2-2001;47:1094-101.

Snow C. Laboratory diagnosis of vitamin B12 and folate defi ciency. Arch Intern Med. 1999;159:1289-98.

Carmel R. Current concepts in cobalamin deficiency. Ann Rev Med. 2000;51:357-75.

Ray J, Cole D, Boss S. An Ontario-wide study of vitamin B12, serum folate and red blood cells in relation to plasma homocysteine: is a preventable public health issue on the rise? Clin Biochem. 2000;33:337-43.

Wright JD, Bialostosky K, Gunter EW, Carroll MD, Najjar MF, Bowman BA, et al. Blood folate and vitamin B12. Vital Health Stat. 1998;11:1-78.

Swain R. An update of vitamin B12 metabolism and defi ciency states. J Fam Pract. 1995;41:595-600.

Baik HW, Russell RM. Vitamin B12 deficiency in the elderly. Ann Rev Nutr. 1999;19:357-77.

Wolters M, Ströhle A, Hahn A. Cobalamin: a critical vitamin in the elderly. Prev Med. 2004;39(6):1256-66.

Allen LH. Causes of vitamin B12 and folate deficiency. Food Nutr Bull. 2008;29(2 Suppl):S20-34.

Halfdanarson TR, Litzow MR, Murray JA. Hematologic manifestations of celiac disease. Blood. 2007;109(2):412-21.

Jabbar A, Yawar A, Waseem S, Islam N, Ul Haque N, Zuberi L, et al. Vitamin B12 deficiency common in primary hypothyroidism. J Pak Med Assoc. 2008;58(5):258-61.

Lam JR, Schneider JL, Zhao W, Corley DA. Proton pump inhibitor and histamine 2 receptor antagonist use and vitamin B12 deficiency. JAMA. 2013;310(22):2435-42.

Reinstatler L, Ping Qt Y, Williamson RS, Garn JV, Oakley Jr GP. Association of biochemical B12 deficiency with metformin therapy and vitamin B12 supplements: The national health and nutrition examination Survey, 1999-2006. Diabetes Care. 2012;35:327-33.

Gupta AK, Damji A, Uppaluri A. Vitamin B12 defi ciency, Prevalence among South Asians at a Toronto clinic. Can Fam Physician. 2004;50:743-7.

Elena C, Horaţiu A, Viorica. Screening of the vitamin B12 status in an urban population sample from Romania: a pilot study. Revista Română de Medicină de Laborator. 2014;22(2):173-9.

Singh B, Gupta VK, Venkatesan M. burden of vitamin b12 deficiency in urban population in delhi,india: a hospital based study. ijpbs: 2011;2(1):B521-8.

Refsum H, Chittaranjan SY, Gadkari M, Schneede J, Vollset SE, Ornig L, et al. Hyperhomocysteinemia and elevated methylmalonic acid indicate a high prevalence of cobalamin defi ciency in Asian Indians. Am J Clin Nutr. 2001;74:233-41.

Premkumar M, Gupta N, Singh T, Velpandian T. Cobalamin and Folic Acid Status in Relation to the Etiopathogenesis of Pancytopenia in Adults at a Tertiary Care Centre in North India. Hindawi Publishing Corporation; Anaemia; Volume 2012. Article ID 707402, 12.