Comparison of fasting lipid profile in ischemic and haemorrhagic stroke patients of a tertiary care hospital


  • Kothai Gnanamoorthy Department of Medicine, SRM Medical College and Hospital, SRM Campus, Potheri, Chennai, Tamil Nadu, India
  • Prasanna Karthik Suthakaran Department of Medicine, Saveetha Medical College Hospital, Saveetha University, Chennai, Tamil Nadu, India
  • Kannan Rajendran Department of Medicine, Saveetha Medical College Hospital, Saveetha University, Chennai, Tamil Nadu, India
  • Keerthi Deepak Department of Medicine, Sri Muthukumaran Medical College Hospital and Research Institute, Mangadu, Chennai, Tamil Nadu, India



Stroke, Cerebrovascular accident, Lipid profile, LDL - C, Ischemic stroke, Haemorrhagic stroke


Background: Stroke is one of the leading causes of death and disability in India. Dyslipidaemia as a risk factor for cerebrovascular accidents have been explored in various studies and have been definitely established with the findings of many landmark trials. The relation of circulating cholesterol to ischemic stroke does not resemble its well-known relation to coronary heart disease and hence needs to be explored in detail.

Methods: 72 patients with a first ever diagnosis of cerebrovascular disease whose onset was within the preceding three days were enrolled in the study. Lipid profile abnormalities were documented in these patients and they were followed up for 30 days.

Results: The mean age was 60.7 ± 11.0 years in the ischemic group and 52.3±10.2 years in the haemorrhagic group (P=0.004). The mean total cholesterol (TC) levels and the mean LDL – cholesterol (LDL – C) levels were higher in the ischemic stroke patients and these differences were statistically very significant. (183.7± 34.5 versus 148.5±30.6, P = 0.0002, 118.7±26.7 versus 81.4±22.0, P = 0.0001) The differences in the mean triglycerides (TG), mean HDL – cholesterol (HDL – C) and mean VLDL – cholesterol (VLDL – C) levels were not statistically significant between the two groups.

Conclusions: In this study, the mean TC and LDL – C levels were significantly much higher in the ischemic stroke patients when compared to patients with haemorrhagic stroke. The findings from this small study suggest that there may be a limit to the lowering of LDL – Cholesterol levels. Some studies have shown that lower levels are associated with increased risk of haemorrhagic stroke rather than ischemic stroke, though conclusive evidence is still lacking.


WHO (1980). Bull WHO, 58: 113-130.

Pandian JD, Sudhan P. Stroke Epidemiology and Stroke Care Services in India. Journal of Stroke. 2013;15(3):128-34.

Stone NJ, Robinson JG, Lichtenstein AH, Merz CNB, Blum CB, Eckel RH, et al. 2013 ACC/AHA Guideline on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in Adults. Circulation. 2014;129:S1-45.

Shahar E, Chambless LE, Rosamond WD, Boland LL, Ballantyne CM, McGovern PG, Sharrett AR. Plasma Lipid Profile and Incident Ischemic Stroke. The Atherosclerosis Risk in Communities (ARIC) Study. Stroke. 2003;34:623-31.

Varbo A, Nordestgaard BG, Tybjærg-Hansen A, Schnohr P, Jensen GB, Benn M. Nonfasting triglycerides, cholesterol, and ischemic stroke in the general population. Ann Neurol. 2011;69:628-34.

Tanne D, Yaari S, Goldbourt U. Risk Profile and Prediction of Long-Term Ischemic Stroke Mortality. A 21-Year Follow-up in the Israeli Ischemic Heart Disease (IIHD) Project. Circulation. 1998;98:1365-71.

Dalal PM, Malik S, Bhattacharjee M, Trivedi ND, Vairale J, Bhat P, et al. Population-Based Stroke Survey in Mumbai, India: Incidence and 28-Day Case Fatality. Neuroepidemiology. 2008;31:254-61.

Sridharan SE, Unnikrishnan JP, Sukumaran S, Sylaja PN, Nayak SD, Sarma PS, Radhakrishnan K. Incidence, Types, Risk Factors, and Outcome of Stroke in a Developing Country : The Trivandrum Stroke Registry. Stroke. 2009;40:1212-8.

Nagaraja D, Gururaj G, Girish N, Panda S, Roy AK, Sarma GR, Srinivasa R. Feasibility study of stroke surveillance: data from Bangalore, India. Indian J Med Res. 2009;130(4):396-403.

García SG, Concepción OF, Carriera RF, Saínz CM, Maza J, Monteagudo AG, Zuaznábar MAB. Association between Blood Lipids and Types of Stroke. MEDICC Review, Spring. 2008;10(2):27-32.

Togha M, Gheini MR, Ahmadi B, Khashaiar P, Razeghi S. Lipid profile in cerebrovascular accidents. Ir J Neurol. 2011;10(1-2):1-4.

Bots ML, Elwood PC, Nikitin Y, Salonen JT, Freire de Concalves A, Inzitari D, et al. Total and HDL cholesterol and risk of stroke. EUROSTROKE: a collaborative study among research centres in Europe. J Epidemiol Community Health. 2002;56(Suppl I):i19–i25.

Chaudhury SR, Ghosh S, Kar D. Comparative lipid profile study between ischemic and haemorrhagic stroke. J Chem Pharm Res. 2014;6(11):20-7.

Thacker AK, Saxena S, Khan J, Saxena SP. Lipid abnormalities associated with Stroke. Ann Ind Acad Neurol. 2005;8:133-8.






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