A case of autoimmune induced necrotizing myopathy

Authors

  • Jaison Udani Department of Physical Medicine and Rehabilitation, Kingsbrook Jewish Medical Center, Brooklyn, NY, USA
  • Kirill Alekseyev Department of Physical Medicine and Rehabilitation, Kingsbrook Jewish Medical Center, Brooklyn, NY, USA
  • Malcolm Lakdawala Department of Physical Medicine and Rehabilitation, Kingsbrook Jewish Medical Center, Brooklyn, NY, USA
  • Jitendra Patel Department of Physical Medicine and Rehabilitation, Kingsbrook Jewish Medical Center, Brooklyn, NY, USA
  • Marc Ross Department of Physical Medicine and Rehabilitation, Kingsbrook Jewish Medical Center, Brooklyn, NY, USA

DOI:

https://doi.org/10.18203/2349-3933.ijam20162535

Keywords:

Autoimmune, Necrotizing myopathy, Rhabdomyolysis, Creatine kinase, Debility, Rehabilitation

Abstract

A 31-year-old female, with no previous past medical history, presented to the emergency department (ED) two weeks after falling while moving furniture complaining of increasing weakness and swelling. Initially, she had minor ankle pain after falling but this progressed to bilateral ankle pain and eventually bilateral shoulder pain. Creatine Kinase (CK) levels were drawn and results showed a level of 30,186. She was diagnosed with rhabdomyolysis and aggressive IV hydration was initiated. After 3 weeks, her CK levels did not decrease below 15,000. A muscle biopsy was performed and revealed a necrotizing myopathy with high probability of autoimmune etiology.

References

Liang C, Needham M. Necrotizing autoimmune myopathy. Current Opinion in Rheumatology. 2011;23(6):612-9.

Allenbach Y, Benveniste O. Acquired Necrotizing Myopathies. Current Opinion in Neurology. 2013;26(5):554-60.

Grable-Esposito P, Katzberg HD, Greenberg SA, Srinivasan J, Katz J, Amato AA.Immune-mediated necrotizing myopathy associated with statins. Muscle Nerve. 2010;41(2):185.

Valiyil R, Casciola RL, Hong G, Mammen A, Christopher-Stine L. Rituximab therapy for myopathy associated with anti-signal recognition particle antibodies: a case series. Arthritis Care Res. 2010;62(9):1328-34.

Miller T, Al-Lozi MT, Lopate G, Pestronk A. Myopathy with antibodies to the signal recognition particle: clinical and pathological features. J Neurol Neurosurg Psychiatry. 2002;73(4):420.

Martín MA, Lucía A, Arenas J, Andreau LA. Glycogen Storage Disease Type V. Gene Reviews [Internet]. 2006 Apr 19.

Giannoglou GD, Chatzizisis YS, Misirli G. The syndrome of rhabdomyolysis: Pathophysiology and diagnosis. Eur J Intern Med. 2007;18(2):90.

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Published

2016-12-29