Clinical profile of patients presented with esophageal carcinoma in tertiary care teaching medical college of Gujarat, India
Keywords:Clinical profile, Esophageal cancer, Endoscopic biopsy
Background: Esophageal cancer is associated with multiple risk factors and associated with poor prognosis. Incidence of Esophageal cancer is increases now a days and it became a sixth leading cause of cancer related death in world. The purpose of this study was to know the clinical profile of patients of esophageal cancer in a tertiary care teaching hospital of Gujrat, India.
Methods: This is a retrospective hospital record based study for a period of 2015 to 2018 in which 103 patients with endoscopic biopsy confirmed cases of esophageal cancer were analyzed for clinical profile.
Results: Esophageal cancer was most common in low socioeconomic men (66%) of 5th decades (26.21%) associated with tobacco chewing (64.07%) as a major risk factor and dysphagia (86.76%) as most common presenting feature. Most common type and involvement were sqamous type (72.81%) and distal third (50.48%) part of the esophagus respectively.
Conclusions: Primordial prevention and screening of patients may decrease mortality related to esophageal carcinoma.
Mao WM, Zheng WH, Ling ZQ. Epidemiologic risk factors for esophageal cancer development. Asian Pac J Cancer Prev. 2011;12:2461-6.
Enzinger PC, Mayer RJ. Esophageal cancer. N Engl J Med. 2003;349:2241-52.
Globocan; 2008. Available at: http;//globocon.iarc.fr/factsheet.aspon. Accessed on: 9th December 2012.
Montgomery EA, Basman FT, Brenan P, Malekzadeh R. Oesophageal cancer. In Stewart BW, Wild CP, World Cancer Report, WHO; 2014:528-543.
Malkan G, Mohandas KM. Epidemiology of digestive cancers in India. I. General principles and esophageal cancer. Indian J Gastroenterol. 1997;16:98-102.
Chen J, Zhang N, Ling Y. Alcohol consumption as a risk factor for adenocarcinoma in North china, Tohoku J Exp Med. 2011;224:21-7.
Das KC, Singh S, Pawar G, Masih R, Raju N. Risk factors analysis of squamous cell carcinoma (SCC) esophagus in North Indian females in tertiary care hospital: A case-control study. Int J Recent Sci Res. 2015;6:4661-4.
Three-Year Report of the Population Based Cancer Registries 2012-2014: Report of 27 PBCRs; National Cancer Registry Programmed. Bangalore: Indian Council Medical Research; 2016. Available at: http://www.ncrpindia.org/ALL_NCRP_REPORTS/PBCR_REPORT_2012_2014/index.htm.
Evans JA, Early DS, Chandraskhara V. The role of endoscopy in the assessment and treatment of esophageal cancer. Gastrointest Endosc. 2013;77:328-34. [PubMed].
Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, et al. Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN. Int J Cance. 2015;136:359-86.
Bray F, Jemal A, Grey N, Ferlay J, Forman D. Global cancer transitions according to the Human Development Index (2008-2030): a population-based study. The Lancet Oncology. 2012 Aug 1;13(8):790-801.
Desai BP, Borges JE, Vohra JV. Carcinoma of esophagus in India. Ind J Gastroenterol. 1997;16:98-101.
Sankaranarayanan R, Duffy SV, Padma Kumaray G, Nair SM, Day NE, Pandanabhan TK. Risk factors for cancer of the esophagus in Kerala, India. Ind J Cance. 1991;49:485-9.
Sehgal S, Kaul S, Gupta BB, Dhar MK. Risk factors and survival analysis of the esophageal cancer in the population of Jammu, India. Ind J Cance. 2012;49:245-50.
Dar NA, Shah IA, Bhat GA, Makhdoomi MA, Iqbal B, Rafiq R, et al. Socioeconomic status and esophageal squamous cell carcinoma risk in Kashmir, India. Cancer Sci. 2013 Sep;104(9):1231-6.
Gupta V, Bhardwaj S, Bhagat OK. Pattern of esophageal cancer in tertiary care hospital in North India: a clinicopathological study. Int J Res Med Sci. 2017;5:1405-9.
Znaor A, Brennan P, Gajalakshmi V, Mathew A, Shanta V, Varghese C, et al. Independent and combined effects of tobacco smoking, chewing and alcohol drinking on the risk of oral, pharyngeal and esophageal cancers in Indian men. Int J Cancer. 2003;105:681-6.
Farin K, Graca MD, William FA. Patterns of cancer incidence, mortality and prevalence across five continents: Defining priorities to reduce cancer disparities in different geographic regions of the world. J Clin Oncol. 2006;24:2137-50.
Giri PA, Singh KK, Phalke DB. Study of socio-demographic determinants of esophageal cancer at a tertiary care teaching hospital of Western Maharashtra, India. South Asian J Cance. 2014;3:54-6.