Published: 2019-03-25

Prevalence of hyperuricemia in newly diagnosed type 2 diabetes mellitus patients

Ankit Grover, A. B. Mowar, Sharat Johri


Background: The relationship between hyperuricemia and diabetes mellitus is proved to be associated with the risk of cardiovascular diseases, but it is unclear whether hyperuricemia is actually related to diabetes.

Methods: A 50 patients with newly diagnosed diabetes according to ADA guidelines were selected. Uric acid level and HbA1C levels were measured. Results were calculated with the reference range of uric acid >7.0 mg/dl.

Results: The mean serum uric acid level was higher in 72% of the newly diagnosed diabetic patients (36/50).

Conclusions: Hyperuricemia seems to be associated with newly diagnosed diabetics. It can be used as a biomarker of deterioration of glucose metabolism.


Diabetes mellitus, Hyperuricemia, Serum, Uric acid

Full Text:



Sudhindra RM, John SB. A study of serum uric acid in diabetes mellitus and prediabetes in a south Indian tertiary care hospital. Nitte Uni J Heal Sci. 2012;2:18-23.

Liu Y, Jin C, Xing A, Liu X, Chen S, Li D, et al. Serum uric acid levels and the risk of impaired fasting glucose: a prospective study in adults of north China. PloS One. 2013;8(12):e84712.

American diabetes association diagnosis and classification of diabetes mellitus. Diab Care. 2010;33(1):S62-69.

Diagnosis and classification of Diabetes Mellitus. Am Diabet Assoc Diab Care. 2004; 27(s1): s5-10.

Yoo TW, Sung KC, Shin HS, Kim BJ, Kim BS, Kang JH, et al. Relationship between serum uric acid concentration and insulin resistance and metabolic syndrome. Circ J. 2005;69:928-33.

Tirkey AS, Ahirvar D. Hyperuricemia, a modifiable risk factor for prediabetes-a cross-sectional study in tertiary care hospital in central India. Transworld Med J. 2014;2(1):40-3.

Hashmi N, Kamble TK. Serum uric acid in Prediabetes. Int J Sci Res. 2018;7(3).

Kodama S, Saito K, Yachi Y, Asumi M, Sugawara A, Totsuka K, et al. Association between serum uric acid and development of type 2 diabetes. Diabetes Care. 2009;32:1737-42.

Griffiths M. The mechanism of the diabetogenic action of uric acid. J Biol Chem. 1950;184:289-98.

Klein BE, Klein R, Lee KE. Components of the metabolic syndrome and risk of cardiovascular disease and diabetes in Beaver Dam. Diab Care. 2002;25:1790-94.

Tsouli SG, Liberopoulos EN, Mikhailidis DP, Athyros VG, Elisaf MS. Elevated serum uric acid levels in metabolic syndrome: an active component or an innocent bystander?. Metabol. 2006;55:1293-301.

Hara S, Tsuji H, Ohmoto Y, Amakawa K, Hsieh SD, Arase Y, et al. High serum uric acid level and low urine pH as predictors of metabolic syndrome: a retrospective cohort study in a Japanese urban population. Metab. 2012;61:281-8.