A study of clinical profile and complications in patients with type 2 diabetes mellitus in a tertiary care centre

Oshin Mantro, Jagadeesan Mohanan, Mahendra Kumar K., Kannan R., Gowri Shankar A., Damodharan J., Magesh Kumar S.


Background: Diabetes is the most common non-communicable disease known today. This study was conducted to assess the clinical profile and complications in patients with type 2 diabetes mellitus.

Methods: A prospective study was carried out between April 2017 to April 2018 in patients attending a tertiary care hospital in Chennai. Patients with type 2 diabetes of age 25-80 years, minimum of 5 years duration were enrolled.

Results: Out of 66 patients, 23(34.8%) were males whereas 43 (65.2%) were females.  Mean age in this study population was 55.36 years with a standard deviation of 11.362. In present study, the mean fasting blood sugar level was 196.12±77.180, mean postprandial blood sugar level was 303.26±115.385 and the mean HbA1C levels was 10.95±2.369. 77.3% were on oral hypoglycaemic agents, 13.6% on insulin and 9.1% on combined therapy with oral hypoglycemic agents and insulin. The complications associated with diabetes found in present study were microvascular complications which include peripheral neuropathy 41(62.1%), retinopathy 31(46.96%), nephropathy 28 (42.42%). Peripheral neuropathy was found to be most commonly associated. Macrovascular complications include cardiovascular disease in 12.12% (n=8) and cerebrovascular disease in 4.54% (n=3). Autonomic neuropathy was found in 69.69% (n=46).

Conclusions: The complications of DM are commonly seen in patients with poor glycaemic control. Among microvascular complications, peripheral neuropathy was most commonly seen. Autonomic neuropathy usually goes unnoticed and asymptomatic in most of the individuals. Increasing levels of HbA1c was found to be significantly correlated with neuropathy.


Autonomic neuropathy, Diabetes mellitus (DM), Macrovascular, Microvascular, Nephropathy, Neuropathy, Retinopathy

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Zimmet P. Globalization, coca-colonization and the chronic disease epidemic: can the dooms day scenario be averted. J Intern Med. 2001;247:301-10.

World Health Organization. Definition, Diagnosis and classification of diabetes mellitus and its complications. Part 1: Diagnosis and classifications of diabetes mellitus Department of Non-communicable Disease Surveillance, Geneva. 1999. Available at:

Papatheodorou K, Banach M, Bekiari E, Rizzo M, Edmonds M. Complications of Diabetes 2017. J Diabetes Res. 2018;2018.

Karavanaki K, Baum JD. Prevalence of microvascular and neurologic abnormalities in a population of diabetic children. J Pediatr Endocrinol. 1999;12:411-22.

Mustonen J, Uusitupa M, Mäntysaari M, Länsimies E, Pyörälä K, Laakso M. Changes in autonomic nervous function during the 4‐year follow‐up in middle‐aged diabetic and nondiabetic subjects initially free of coronary heart disease. J Int Med. 1997;241(3):231-9.

Vinik AI, Erbas T. Recognizing and treating diabetic autonomic neuropathy. Cleve Clin J Med. 2001;68:928-44.

Harrison`s textbook of internal medicine. 19th ed. Diabetes Mellitus: Diagnosis, classification, and pathophysiology. 2013;417:2400-1.

Wein TH, Albers JW. Diabetic neuropathies. Phys Med Rehabil Clin N Am. 2001;12:307-20.

Vinik AI, Maser RE, Mitchell BD, Freeman R. Review article on Diabetic autonomic neuropathy. Diabetes care. 2003;26:1553-79.

Purty JA, Vedapriya DR, Vishwanathan M. Prevalence of diagnosed diabetes in an urban area of punducherry. Int J Diabetes Dev Ctries. 2009;29 (1):6-11.

Birajdar SV, Chavan SS, Munde SA, Bende YP. A study of autonomic nervous system dysfunction among patient with diabetes mellitus: a cross sectional study. Int J Adv Med. 2017;4:406-11.

Zhang R, Li Y, Zhang S, Cai X, Zhou X, Ji L. The association of retinopathy and plasma glucose and HbA1c: a validation of diabetes diagnostic criteria in a Chinese population. J Diabetes Res. 2016;2016.

Penno G, Solini A, Bonora E, Fondelli C, Orsi E, Zerbini G, et al. HbA1c variability as an independent correlate of nephropathy, but not retinopathy, in patients with type 2 diabetes: the renal insufficiency and cardiovascular events (RIACE) italian multicenter study. Diabetes Care. 2013;36(8):2301-10.

Ewing DJ, Campbell IW, Murray A, Neilson JM, Clarke BF. Immediate heart-rate response to standing: simple test for autonomic neuropathy in diabetes. Br Med J. 1978;1(6106):145-7.

Kudrimoti NB. Assessment of cardiac autonomic neuropathy in type 2 diabetes subjects. J Diabetic Assoc. 1987;22(5):221.