A study focusing emerging risk factors in patients of acute myocardial infarction in South India

Rangamanikandan M., Balasubramanian S., Veeramani S. R., Sivakumar G. S., Saravanan R. R., Ramesh R., Sathsihkumar S., Hemanath T. S., Saravanan M., Selvarani G., Nagasundar .


  1. Background: Acute myocardial infarction (MI) is a significantly raising problem particularly in India. The various aspects of myocardial infarction such as risk factor profiles, clinical presentations and prognosis differ significantly in south Indian people when compared to others. This study was undertaken to study the association of socio-demographic and life-style factors with acute myocardial infarction in South India.

    Material: This was a prospective study included 100 patients admitted in ICCU for acute MI in Government Rajaji Hospital Madurai over a period of 1 year. History, ECG, CPK-MB, and 2-D Echo was done to diagnose MI.

    Results: In this study, 68% patients were males. In this study, 34% patients had diabetes, 42% had hypertension, 58% were smokers. In our study 70% patients had BMI between 25-30kg/m2. In this study, 86% patients had TGL more than 200mg/dl, 28% patients had LDL more than 100 mg/dl and 78% patients had NON-HDL more than 130 mg/dl. In this study, 9 patients had depression. In our study 61% male patients had waist hip ratio more than >1 and in females 69% patients had waist hip ratio more than >0.85. In our study, 22% patients had hemoglobin >16g/dl.

    Conclusion: Prevention of coronary artery syndrome by modifying the risk factors were crucial. Serum cholesterol, LDL cholesterol, BMI were not significant to predict ACS in our study Waist Hip ratio, Triglyceride, Non-HDL cholesterol, smoking and Depression were significant to predict acute coronary syndrome in this study.

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Prabhakaran D, Jeemon P, Roy A. Cardiovascular diseases in India: current epidemiology and future directions. Circulation. 2016:19;133(16):1605-20.

Deans KA, Bezlyak V, Ford I, Batty GD, Burns H, Cavanagh J, et al. Differences in atherosclerosis according to area level socioeconomic deprivation: cross sectional, population-based study. BMJ. 2009;27(339):4170.

Singh RB, Mengi SA, Xu YJ, Arneja AS, Dhalla NS. Pathogenesis of atherosclerosis: a multifactorial process. Exp Clin Cardiol. 2002;7(1):40.

Spiteller G. Is atherosclerosis a multifactorial disease or is it induced by a sequence of lipid peroxidation reactions?. Ann N Y Acad Sci. 2005;1043:355-66.

Wierzbicki WB, Hagmeyer KO. Helicobacter pylori, Chlamydia pneumoniae, and cytomegalovirus: chronic infections and coronary heart disease. Pharmacother: J Hum Pharmacol Drug Ther. 2000 Jan;20(1):52-63.

Yusuf S, Hawken S, Ounpuu S, Dans T, Avezum A, Lanas F, et al. Inter heart Study Investigators. Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries: Case-control study. 2004;364(9438):937-52.

Zodpey SP, Shrikhande SN, Negandhi HN, Ughade SN, Joshi PP. Risk factors for acute myocardial infarction in Central India: A case-control study. Indian journal of community medicine: official publication of Indian Assoc Prev Social Med. 2015;40(1):19.

Sekhril T, Kanwar RS, Wilfred R, Chugh P, Chhillar M, Aggarwal R, et al. Prevalence of risk factors for coronary artery disease in an urban Indian population. BMJ Open. 2014;4(12):e005346.

Ramachandran A, Snehalatha C, Kapur A, Vijay V, Mohan V, Das AK, et al, Diabetes Epidemiology Study Group in India (DESI. High prevalence of diabetes and impaired glucose tolerance in India: National Urban Diabetes Survey. Diabetol. 2001; 44(9):1094-101.

Gupta R, Gupta VP, Ahluwalia NS Educational status, coronary heart disease and coronary risk factors prevalence in a rural population of India. BMJ. 1994;309(6965):1332-6.

Goel PK, Bharti BB, Pandey CM, Singh U, Tewari S, Kapoor A, et al, A tertiary care hospital-based study of conventional risk factors including lipid profile in proven coronary artery disease. Indian Heart J. 2003;55(3):234-40.

Prabhakaran D, Shah P, Chaturvedi V, Ramakrishnan L, Manhapra A, Reddy KS. Cardiovascular risk factor prevalence among men in a large industry of northern India. National Med J India. 2005;18(2):59.

Mohan V, Deepa R. Risk factors for coronary artery diseases in Indians. J Assoc Physicians India. 2004;52:95-7.

Epidemiologic study of diet and coronary risk factors in relation to central obesity and insulin levels in the rural and urban populations of north India. Int J Cardiol. 1995;47(3):245-55.

Joseph A, Kutty VR, Soman CR. High risk for coronary heart disease in Thiruvananthapuram city: a study of serum lipids and other risk factors. Ind Heart J. 2000;52(1):29-35.