A study of C reactive proteins in patients with stable chronic obstructive pulmonary disease

Ashok Kumar Gudagunti; Sudhir Chaudhri

doi:10.18203/2349-3933.ijam20191037

Authors

Ashok Kumar Gudagunti Department of Pulmonary Medicine, Karnataka Institute of Medical Sciences, Hubballi, Karnataka, India
Sudhir Chaudhri Department of Pulmonary Medicine, Murari Lal Chest Hospital, GSVM Medical College, Kanpur, Uttar Pradesh, India

DOI:

https://doi.org/10.18203/2349-3933.ijam20191037

Keywords:

Chronic obstructive pulmonary disease, C reactive proteins, Stable

Abstract

Background: Whenever there is damage to the tissue or inflammatory process, the hepatocytes synthesize a protein which is an acute phase reactant, and this is the C reactive protein. Studies have shown that serum C reactive protein levels are usually elevated during acute exacerbations of COPD. The objective of this study was studying the baseline serum C reactive protein levels in patients with stable chronic obstructive pulmonary disease.

Methods: During the study period, 90 subjects were studied. Out of them, 47 had stable COPD and 43 were without COPD. The subjects were either admitted in indoor wards or were attending OPD of department of tuberculosis and respiratory diseases, Dr. Murari Lal Chest Hospital, G.S.V.M Medical College, Kanpur, Uttar Pradesh, and were recruited if they fulfilled the criteria for inclusion. Informed consent was taken from all study subjects and the study protocol was approved by the board of faculty of medicine.

Results: Of the 47 patients in the stable COPD group, 23 were found to be active smokers. Pearson’s correlation coefficient showed that lower limit of serum CRP levels were significantly negatively correlating with 6 MWD (r= -0.707; p=0.0001), FEV1% (r=-0.635; p=0.0001), PaO₂ (r=-0.592; p=0.0001), and BMI (r= -0.534; p=0.0001). Pearson’s correlation coefficient showed that upper limit of serum CRP levels were significantly negatively correlating with 6 MWD (r= -0.707; p=0.0001), FEV1% (r= -0.633; p=0.0001), PaO₂ (r= -0.61; p=0.001) and BMI (r= -0.520; p=0.0001).

Conclusions: The circulating levels of inflammatory marker, baseline serum CRP are significantly elevated in patients with stable chronic obstructive pulmonary disease.

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References

Barnes PJ. Chronic obstructive pulmonary disease. N Engl J Med. 2000;343:269-80.

Sin DD, Man SP. Why are patients with chronic obstructive pulmonary disease at increased risk of cardiovascular diseases? The potential role of systemic inflammation in chronic obstructive pulmonary disease. Circulat. 2003;107(11):1514-9.

Burney PG, Patel J, Newson R, Minelli C, Naghavi M. Global and regional trends in COPD mortality, 1990-2010. European Respirat J. 2015;45(5):1239-47.

Koniski ML, Salhi H, Lahlou A, Rashid N, El Hasnaoui A. Distribution of body mass index among subjects with COPD in the Middle East and North Africa region: data from the breathe study. Int J Chronic Obstructive Pulmonary Dis. 2015;10:1685.

Poulain M, Doucet M, Drapeau V, Fournier G, Tremblay A, Poirier P, et al. Metabolic and inflammatory profile in obese patients with chronic obstructive pulmonary disease. Chronic Resp Dis. 2008;5(1):35-41.

Mannino DM, Buist AS, Vollmer WM. Chronic obstructive pulmonary disease in the older adult: what defines abnormal lung function?. Thorax. 2007;62(3):237-41.

Gan WQ, Man SF, Senthilselvan A, Sin DD. Association between chronic obstructive pulmonary disease and systemic inflammation: a systematic review and a meta-analysis. Thorax. 2004;59(7):574-80.

Yende S, Waterer GW, Tolley EA, Newman AB, Bauer DC, Taaffe DR, et al. Inflammatory markers are associated with ventilatory limitation and muscle dysfunction in obstructive lung disease in well functioning elderly subjects. Thorax. 2006;61(1):10-6.

Broekhuizen R, Wouters EF, Creutzberg EC, Schols AM. Raised CRP levels mark metabolic and functional impairment in advanced COPD. Thorax. 2006;61(1):17-22.

Pinto-Plata VM, Müllerova H, Toso JF, Feudjo-Tepie M, Soriano JB, Vessey RS, et al. C-reactive protein in patients with COPD, control smokers and non-smokers. Thorax. 2006;61(1):23-8.

Dahl M, Vestbo J, Lange P, Bojesen SE, Tybjærg-Hansen A, Nordestgaard BG. C-reactive protein as a predictor of prognosis in chronic obstructive pulmonary disease. Am J Resp Critical Care Med. 2007;175(3):250-5.

Ólafsdóttir IS, Gislason T, Thjóđleifsson B, Olafsson I, Gislason D, Jõgi R, et al. Gender differences in the association between C-reactive protein, lung function impairment, and COPD. Int J Chronic Obstructive Pulmonary Dis. 2007;2(4):635.

Breyer MK, Spruit MA, Celis AP, Rutten EP, Janssen PP, Wouters EF. Highly elevated C-reactive protein levels in obese patients with COPD: a fat chance?. Clinic Nutrit. 2009;28(6):642-7.

De Torres JP, Cordoba-Lanus E, López-Aguilar C, de Fuentes MM, De Garcini AM, Aguirre-Jaime A, et al. C-reactive protein levels and clinically important predictive outcomes in stable COPD patients. European Respirat J. 2006;27(5):902-7.