Body mass index, obstruction of the airflow, dyspnea, and exercise capacity index as predictor of the severity of exacerbations and systemic involvement in patients with COPD
DOI:
https://doi.org/10.18203/2349-3933.ijam20191023Keywords:
Airflow obstruction, Body-mass index, Chronic obstructive pulmonary disease, Dyspnoea and exercise (BODE) index, Exacerbations, PredictAbstract
Background: Allocation of the limited resources to the needed patients and decision making regarding timely interventions demand development of a reliable, cost effective, simple assessment tool. Several studies propose body-mass index, airflow obstruction, dyspnea, and exercise (BODE) index for this purpose in patients with Chronic obstructive pulmonary disease (COPD). The objective of this study was to assess the utility of BODE index to predict the severity of exacerbations and systemic involvement in COPD.
Methods: A Present hospital based cross sectional study was carried out among 100 COPD patients. BODE index was used to assess the patients and its association was studied with various variables. The data was analyzed using one-way analysis of variance (ANOVA) test.
Results: As the body index class of severity increases, the number of hospitalizations required in the past also increases and this association is statistically significant. As the severity of the disease increased as indicated by the class the mean number of exacerbations in the past increased and this association was found out to be statistically significant. As the severity of the disease increased as indicated by the class level, the mean number of days of hospitalization increased. But this increase was of small difference and hence on one-way ANOVA test was not found out to be statistically significant. As the pack years increases, the BODE index increases significantly (p value <0.001). As the severity of the disease increased, the mean body mass index decreased. Haemoglobin level was found to decrease with increase in BODE index class of severity. This association was statistically significant.
Conclusions: The BODE index has been found to be a very good tool to assess the prognosis of COPD as well as severity of acute exacerbations.
References
Rycroft CE, Heyes A, Lanza L, Becker K. Epidemiology of chronic obstructive pulmonary disease: a literature review. Int J Chronic Obstruct Pulmonary Dis. 2012;7:457.
Salvi S, Agrawal A. India needs a national COPD prevention and control programme. 2012;60:5-7.
GOLD - Global Initiative for chronic lung disease -pocket guide to COPD diagnosis, management, and prevention. A Guide for health care professionals. 2017 edition. Available at: www.goldcopd.org. Accessed 5 August 2017.
Nageswari AD, Gampala UK, Rajanandh MG. Comparison between spirometry and BODE Index for clinical assessment in chronic obstructive pulmonary disease Patients. Trends Med Res. 2015;10(1):12-8.
Celli BR, Cote CG, Marin JM, Casanova C, Montes de Oca M, et al. The body-mass index, airflow obstruction, dyspnea, and exercise capacity index in chronic obstructive pulmonary disease. New Eng J Med. 2004;350(10):1005-12.
Shivakumar BG, Krishna V. Study of Bode index as a predictor of severity and systemic involvement in patients with COPD. Indian J Basic Appl Med Res. 2015;4:395-404.
Ong KC, Earnest A, Lu SJ. A Multidimensional Grading System (BODE Index) as predictor of hospitalization for copd. Chest. 2005;128:3810-16.
Mckellar A, Cottrell WN, Whelan A. BODE score is a useful predictor of hospital admission in rural patients with chronic obstructive pulmonary disease. Respirol. 2008;13(3):438-43.
Faganello MM, Tanni SE, Pelegrino NR, Lucheta PA, Godoy I, Sanchez FF. BODE index and GOLD staging as predictors of 1-year exacerbation risk in chronic obstructive pulmonary disease. Am J Med Sci. 2010;339(1):10-4.
B, García-Polo C, Herrejón A, Ruiz LA, de Miguel J, Ros JA, et al. Factors associated with hospital admission for exacerbation of chronic obstructive pulmonary disease. Arch Bronconeumol. 2012;48(3):70-6.
Yamauchi Y, Hasegawa W, Yasunaga H, Sunohara M, Jo T, Takami K, et al. Paradoxical association between body mass index and in-hospital mortality in elderly patients with chronic obstructive pulmonary disease in Japan. Int J Chronic Obstruct Pulmonary Dis. 2014;9:1337.
Ardestani ME, Zaerin O. Role of serum interleukin 6, albumin and C-reactive protein in COPD patients. Tanaffos. 2015;14(2):134.
Jeswani G, Kumar J, Soni ND. Prevalence of anemia in COPD patients of Jodhpur, Rajasthan, India. Indian J Physical Med Rehabilitation 2014;2(5):760-6.
Silverberg DS, Mor R, Weu MT, Schwartz D, Schwartz IF, Chernin G. Anemia and iron deficiency in COPD patients: prevalence and the effects of correction of the anemia with erythropoiesis stimulating agents and intravenous iron. BMC Pulmonary Med. 2014;14(1):24.
Kalaycıoğlu E, Gökdeniz T, Aykan AÇ, Hatem E, Gürsoy MO, Toksoy F, et al. Evaluation of left ventricular function and its relationship with multidimensional grading system (BODE index) in patients with COPD. J Chronic Obstruct Pulmonary Dis. 2015 Sep 3;12(5):568-74.
