Study of serum HDL-cholesterol levels in sepsis patients and its prognostic significance


  • Bhargav Kiran Gaddam Department of General Medicine, Mahatma Gandhi Medical College and Research Institute, Sri Balaji Vidyapeeth, Pillaiyarkuppam, Pondicherry, India
  • M. Narayanan Department of General Medicine, Mahatma Gandhi Medical College and Research Institute, Sri Balaji Vidyapeeth, Pillaiyarkuppam, Pondicherry, India



Correlation, HDL-cholesterol, Sepsis, SOFA score, Survival


Background: Sepsis is the second leading cause of mortality in the ICU. Despite advances in aggressive management, sepsis continues to have a high mortality rate, hence a prognostic marker is essential. Recently HDL-cholesterol was found to be have significant association between mortality and its levels. Hence, this study is being conducted to assess the association between sepsis and HDL-C levels.

Methods: It is a prospective study conducted in MGMCRI involving 100 sepsis patients. Among them 66 people survived, and 34 people expired. Serum HDL-cholesterol levels and variables required for SOFA score are measured at two intervals, one during admission and on day 5 of admission. The correlation between SOFA scores and HDL-C levels were assessed.

Results: Among non-survivors SOFA score was found to be high and low in the survived patients. Similarly, HDL-C values, were high in survived patients and low in dead patients. The correlation between SOFA scores and HDL in both survivors and non survivors, both at the time of admission and at day 5 were found to be statistically significantly correlated.

Conclusions: This study proves the significant relationship between the HDL values and the SOFA scores. Hence, HDL-cholesterol levels can be used to measure the prognosis and therapeutic efficacy in cases of sepsis. Rising values of HDL cholesterol favour improvement in clinical condition and falling values imply worsening and there by providing a prognostic indicator.


Vincent JL, Sakr Y, Sprung CL, Ranieri VM, Reinhart K, Gerlach H, Moreno R, Carlet J, Le Gall JR, Payen D. Sepsis in European intensive care units: results of the SOAP study. Crit Care Med. 2006;34(2):344-53.

Martin GS, Mannino DM, Eaton S, Moss M. The epidemiology of sepsis in the United States from 1979 through 2000. New Eng J Med. 2003;348(16):1546-54.

Todi S, Chatterjee S, Sahu S, Bhattacharyya M. Epidemiology of severe sepsis in India: an update. Crit Care. 2010;14(1):P382.

Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, Bellomo R, Bernard GR, Chiche JD, Coopersmith CM, Hotchkiss RS. The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA. 2016;315(8):801-10.

Murch O, Collin M, Hinds CJ, Thiemermann C. Lipoproteins in inflammation and sepsis. I. Basic science. Intensive Care Med. 2007;33(1):13-24.

Herzum I, Renz H. Inflammatory markers in SIRS, sepsis and septic shock. Current Med Chem. 2008;15(6):581-7.

Wendel M, Paul R, Heller AR. Lipoproteins in inflammation and sepsis. II. Clinical aspects. Intensive Care Med. 2007;33(1):25-35.

Sunayana P, Renymol B, Ambili NR. Fasting Lipid Profile and Disease Severity in Sepsis Patients. J Clin Diagn Res. 2017;11(11).

Monigari N, Vidyasagar S, Elagandula J. Study of Serum HDL Levels in Severe Sepsis Patients in Medical Intensive Care Unit. Int J Sci Research Publicati. July 2015;5(7):1-13.

Martin GS, Mannino DM, Moss M. The effect of age on the development and outcome of adult sepsis. Crit Care Med. 2006;34(1):15-21.

Mahmood K, Eldeirawi K, Wahidi MM. Association of gender with outcomes in critically ill patients. Crit Care (London, England). 2012;16(3):R92.

Angele MK, Pratschke S, Hubbard WJ, Chaudry IH. Gender differences in sepsis: cardiovascular and immunological aspects. Virulence. 2013;5(1):12-9.

Wang HE, Shapiro NI, Griffin R, Safford MM, Judd S, Howard G. Chronic medical conditions and risk of sepsis. PloS One. 2012;7(10):e48307.

Jeyasuriya A, Badrinath AK, Nagalingam S. Cholesterol levels: the prognostic significance in ICU patients. Int J Adv Med. 2018;5:652-7.






Original Research Articles