DOI: http://dx.doi.org/10.18203/2349-3933.ijam20202594

Frequency of opportunistic infection in PL HIV and its role in monitoring of ART 1 failure

Narendra Singh, Lalit Kumar, Desh Nidhi Singh, Vipin Kumar

Abstract


Background: There is so many opportunistic infection is present in PL HIV patient when patient immunity disturbed and their CD4 count decreased .this study was conducted for frequency of opportunistic infection in PL HIV and its role in monitoring of ART 1 failure. Aims and objective was to study the frequency of opportunistic infection in PL HIV and its role in monitoring of ART1 failure.

Methods: This study was conducted in ART plus centre K.P.S. Post Graduate Institute of Medicine (G.S.V.M. Medical College, Kanpur) tertiary care teaching hospital and is clinical (assessment with investigation) continuous longitudinal, prospective and retrospective, observational, single centre hospital based study at ART Centre, Kanpur and considered All the patient on 1st line ART treating attending in centre were screened for treatment failure decided by SACEP from 2016 to 2018.

Results: In this study there was opportunistic infection present that maximum in oral candidiasis but overall tuberculosis is maximum that is considered pulmonary tuberculosis, extra pulmonary tuberculosis, tubercular lymphadenitis and tubercular pericarditis, Abdominal knocks, TBM. LRTI and chronic diarrhea is also present. The male and rural area are more having opportunistic infections and all are have CD4 count 100 to 200 micrometer /Litre.

Conclusions: The opportunistic infection mostly are oral candidiasis and tuberculosis, present in CD4 count in the range of 100-200 /ml.it is the indication of ART failure during treatments.


Keywords


ART, CD4, Human immunodeficiency virus, LRTI, SACEP, TBM

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References


Takalkar AA, Saiprasad GS, Prasad VG, Madhekar NS. Study of opportunistic infections in HIV seropositive patients admitted to Community Care Centre (CCC), KIMS Narketpally. Biomed Res. 2012;23(1):139-42.

Pandharpurkar D, Devulpally N, Gouthami B, Krishna G. Spectrum of Opportunistic infection in relation to CD4 -count in HIV/AIDS patients admitted in the department of general medicine of tertiary care hospital. Int J Adv Med. 2019;6(3)845-50

Inamdar SA, Kosambiya JK, Modi A, Gohil A, Mehta A, Patel T. Age and Opportunistic Infection: Prevelance and Predictors among Older people with HIV. Nat J Commu Med. 2018;9(8).

Iroezindu MO, Ofondu EO, Hausler H, Van Wyk B. Prevelance and Risk Factors Opportunistic infections in HIV Patient Recieving Antiretroviral Therapy in a Resource - Limited setting in Nigeria. J AIDS Clini Res. 2013;3:002.

Dereje N, Moges K, Nigatu Y, Holland R. Prevalence and Predictors Of Opportunistic Infections Among HIV Positive Adults On Antiretroviral Therapy (On-ART) Versus Pre-ART In Addis Ababa, Ethiopia: A Comparative Cross-Sectional Study. HIV/AIDS (Auckland, NZ). 2019;11:229.

Weldegebreal T, Ahmad I, Abiyou Muhiye Belete S, Bekele A, Kaba M. Magnitute of opportunistic disease and their predictor among adult people living with HIV enrolled in care national levelcross sectional study Ethopia. BMC Public Health. 2018;18(1):820.

Solomon FB, Angore BN, Koyra HC, Tufa EG, Berheto TM, Admasu A. Spectrum of opportunistic infections and associated factors among people living with HIV/AIDS in the era of highly active anti-retroviral treatment in Dawro Zone hospital ;A retrospective study. BMC Res Notes. 2018;11:604.

Patel D, Desai M, Shah AN, Dikshit RK. Early outcome of second line antiretroviral therapy in treatment-experienced human immunodeficiency virus positive patients. Perspe Clini Res. 2013;4(4):215.

Mahy M, Autenrieth CS, Stanecki K, Wynd S. Increasing trends in HIV prevalence among people aged 50 years and older: evidence from estimates and survey data. AIDS (London, England). 2014;28(4):S453.