The study of clinical, biochemical and hematological profile in malaria patients


  • Prashant Khuraiya Department of Medicine, MGMMC & MYH, Indore, Madhya Pradesh, India
  • Shiv Shankar Sharma Department of Medicine, MGMMC & MYH, Indore, Madhya Pradesh, India
  • Ashok Singh Thakur Department of Medicine, MGMMC & MYH, Indore, Madhya Pradesh, India
  • V. P. Pandey Department of Medicine, MGMMC & MYH, Indore, Madhya Pradesh, India
  • Shaily Verma Department of Medicine, MGMMC & MYH, Indore, Madhya Pradesh, India



Malaria, Clinical features, Hematological parameters, Biochemical parameters, Acute febrile illness


Background: Malaria is a major health problem in India. Malaria is the most important parasitic infection which causes major health challenges. Malaria pathogenesis is based on extensive changes in hematological and biochemical parameters. The objective of this study was to study the clinical features, hematological and biochemical parameters in malaria patients and correlate them.

Methods: The present study was done in the department of medicine, M.G.M.M.C & M.Y.H. Indore (M.P.). In this study various signs and symptoms and frequency of changes in hematological and biochemical parameters caused by Plasmodium species were determined. Mean, standard deviation, minimum, maximum values of laboratory alterations were noted and associations were calculated.

Results: 104 patients who had peripheral smear positive for malaria parasite were included in this study. Out of these 104 patients 53 (50.96%) patients of P. falciparum, 48 (46.15%) patients of P. vivax and 3 (2.88%) patients of mixed infection. In the present study most common system involved was haematological (69%) followed by hepatic (42.3%), renal (29.04%), neurological (28.84%), cardiovascular (16.34%) and pulmonary (2.88%).

Conclusions: Malaria though potentially treatable, still kills many patients every year in India. The most common presentation of malaria is fever, so in endemic region malaria may be considered as a leading differential diagnosis in all patients presenting as acute febrile illness, especially patients who also have organomegaly, fall in hemoglobin level, thrombocytopenia and altered liver function tests. Therefore, it is vital to know and perform hematological and biochemical investigations to detect early complications and to treat them effectively.


Snow RW, Guerra CA, Noor AM, Myint HY, Hay SI. The global distribution of clinical episodes of Plasmodium falciparum malaria. Nature. 2005;434:214-7.

Yadav D, Chandra J, Dutta AK. Benign tertian malaria: how benign is it today? Indian J Pediatr. 2012;79(4):525-7.

Guidelines for diagnosis and treatment of Malaria in India 2009, second edition, 2011.

Lathia TB, Joshi R. Can hematological parameters discriminate malaria from non malarious acute febrile illness in the tropics? Indian J. Med. Sci. 2004;58:239-44.

Price RN, Simpson JA, Nosten F, Luxemburger C, Hkirjaroen L, Ter Kuile F et al. Factors contributing to anaemia after uncomplicated falciparum malaria. Am. J. Trop. Med. Hyg. 2001;65(5):614-22.

Kochar D, Das A, Kochar S, Saxena V, Sirohi P, Garg S. Severe Plasmodium vivax malaria: A report on series cases from Bikaner in North western India. Am J Trop Med Hyg. 2009;80(2):194-8.

WHO. World Malaria Report 2014. WHO, Geneva. 2014. Available at Accessed on 01 January, 2016.

Hussian MM, Sohali M, Abhishek K, Raziuddin M. Investigation on Plasmodium vivax infection influencing the host factors in tribal dominant and malaria endemic population of Jharkhand. Saudi J Biol Sci. 2013;20(2):195-203.

Saha AK, Maitra S, Hazra SC. Comparison of hematological parameters between Plasmodium falciparum, Plasmodium vivax and control group. IJMRHS. 2014;3(1):120-7.

Galande CJ, Desai RR, Aundhakar SC, Patange AP, Goel UK. Study of clinical profile of malaria in tertiary referral centre in western Maharashtra. ISSN: 2249-9571.

Davis TM, Krishna S, Loopreesuwan, Supanaranond W, Pukruttayakamee S, Attatamsooonthorn & white NJ. Erythrocyte sequestration and anaemia in severe falciparum malaria. Analysis of acute changes in venous hematocrit using a simple mathematical model. J Clin Invest. 1990;86(3):793-800.

Wickramasinghe SN, Abdulla SH. Blood and bone marrow changes in malaria. Ballieres Best Pract Res Clin Haematol. 2000;13:277-99.

Thawani N, Tam M, Stevenson MM, STAT 6 mediated suppression of erythropoiesis in an experimental model of malaria anaemia. Haematologica. 2009;94(2):195-204.

Chang KH, Stevenson MM. Malarial anaemia: mechanisms and implications of insufficient erythropoiesis during blood-stage malaria. Int J Parasital. 2004;34:1501-16.

Khatib Y, Patel R, Sequeira K, Agrawal G, Chikhale N. Hematological and biochemical alterations in malaria and their correlation with Parasitic Index. IOSR J Pharm. 2015;5(9):53-6.






Original Research Articles