Spectrum of prostate gland lesions: a clinico-pathologic study in south-western Bihar, India
DOI:
https://doi.org/10.18203/2349-3933.ijam20192258Keywords:
Benign nodular hyperplasia, Hemangiopericytoma, Papillary carcinoma, Prostate adenocarcinoma, Sarcomatoid carcinomaAbstract
Background: Prostate gland is an endocrine dependent organ in males and age-related lesions involve it. Inflammation, benign nodular hyperplasia and tumours are the commonest to involve it worldwide. Occasionally some other pathological changes can also involve it. The study was carried out for the first time to know the spectrum and prevalence of prostate lesions which will be of help to the clinicians in this location.
Methods: Retrospective study was carried out for a period of four years and out of surgical cases of males which underwent operative procedure, prostate cases were retrieved and in the department of pathology, haematoxylin and eosin stained slides were evaluated and diagnosed.
Results: A total of 138 cases were included and five cases were excluded from this series. Benign nodular hyperplasia (73.9%) was the commonest finding followed by chronic prostatitis associated with hyperplasia (15.2%), atypical glandular hyperplasia (2.9%) and prostatic intraepithelial neoplasia (2.1%). Malignant tumours were 5.8% constituting adenocarcinoma prostate as the most common (62.5%). A case of hemangiopericytoma was also diagnosed.
Conclusions: Benign nodular hyperplasia of prostate is the most common affliction among males starting at age 45 years. Early consultation and screening will be of immense value. Adenocarcinoma prostate may involve at age around 58 years.
References
Lee CH, Akin-Olugbade O, Kirschenbaum A. Overview of prostate anatomy, histology and pathology. Endocrinol Metab Clin North Am. 2011;40(3):565-75.
Epstein JI. The lower urinary tract and male genital system- Prostate. In: Kumar V, Abbas AK, Nelson F, Aster JC, eds. Robbins and Cotran’s Pathologic Basis of Disease. 8th Ed. Philadelphia: Elsevier; 2010:993-1002.
Vani BR, Kumar D, Sharath BN, Murthy VS, Geethamala K. A comprehensive study of prostate pathology in correlation with prostate-specific antigen levels: An Indian study. Clin Cancer Investig J. 2015;4:617-20.
Maru AM, Makwana HH, Lakum NR, Chokshi T, Agnihotri A, Trivedi N, et al. Study on correlation between prostate specific antigen (PSA) and various prostatic pathology. Int J Med Sci Pub Heal. 2014;3:735.
Chukwuemeka CN, Olalekan SK, Emmanuel KA. A histopathological study of prostate lesions in Lagos, Nigeria: a private practice experience. Niger Med J. 2015;56(5):338-43.
Pacelli A, Bostwick DG. Clinical significance of high-grade prostatic intraepithelial neoplasia in transurethral resection specimens. Urol. 1997;50(3):355-9.
Nghiem HT, Kellman GM, Sandberg SA, Craig BM. Cystic lesions of the prostate. Radiographic. 1990;10(4):635-50.
Mittal BV, Amin MB, Kinare SG. Spectrum of histological lesions in 185 consecutive prostatic specimens. J Postgrad Med. 1989;35:157.
Epstein JI, Woodruff JM. Adenocarcinoma of the prostate with endometroid features. A light microscopic and immunohistochemical study of ten cases. Cancer. 1986;57(1):111-9.
Losi L, Brausi M, Di Gregorio C. Rare prostatic carcinomas:histogenesis and morphologic pattern. Pathologica. 1994;86(4):366-70.
Khant VS, Goswami H, Shah PY. Correlation of serum prostate-specific antigen level in various prostate pathology in elderly men. Int J Med Sci Pub Heal. 2017;6.
Shah RB, Zhou M. Recent advances in prostate cancer pathology: Gleason grading and beyond. Pathol Int. 2016;66(5):260-72.
Aslam HM, Shahid N, Shaikh NA, Shaikh HA, Saleem S, Mughal A. Spectrum of prostate lesions. Int Arch Med. 2013;6:36.
Anunobi CC, Akinde OR, Elesha SO, Daramola AO, Tijani KH, Ojewola RW. Prostate diseases in Lagos, Nigeria: A histologic study with tPSA correlation. Nigerian Postgraduate Med J. 2011;18(2):98-104.
Garg M, Kaur G, Malhotra V, Garg R, Histopathological spectrum of 364 prostatic specimens including immunohistochemistry with special reference to grey zone lesions. Prostate Int. 2013;1(4):146-51.
Kumar M, Khatri SL, Saxena V, Vijay S. Ind J Basic App Med Res. 2016;6(1):695-704.
Wernert N, Luchtrath H, Seeliger H, Schafer M, Goebbels R, Dhom G. Papillary carcinoma of the prostate, location, morphology, and immunohistochemistry: the histogenesis and entity of so-called endometriod carcinoma. Prostate. 1987;10(2):123-1.
Hansel DE, Epstein JI. Sarcomatoid carcinoma of the prostate: a study of 42 cases. Am J Surg Pathol. 2006;30(10):1316-21.
Onur A, Eymen G, Neslihan IZ, Yusuf K, Ahmet C, Ahmet HY. Sarcomatoid carcinoma of the prostate. Case Rep Urol. 2013;2013:631809.
Ronchi A, La Mantia E, Gigantino V, Perdona S, De Sio M, Facchini G, et al. A rare case of malignant solitary fibrous tumor in prostate with review of the literature. Diagn Pathol. 2017;12(1):50.
Ishiguro K, Yamakoshi T, Okishio N, Tamai H, Naide Y, Kasahara M. Hemangiopericytoma of the prostate: a case report. Hinyokika Kiyo. 1984;30(7):931-4.
