The study of prevalence of hyperuricemia and metabolic syndrome in type 2 diabetes mellitus
Keywords:Atherogenic dyslipidemia, Cardiovascular risk, Central obesity, Hypertension, Hyperuricemia, Metabolic syndrome, Type 2 diabetes mellitus
Background: Type 2 diabetes mellitus (Type 2 DM) is associated with cardiovascular complications, of which metabolic syndrome plays a prominent role. The metabolic syndrome is a cluster of cardiovascular risk factors characterized by central obesity, insulin resistance, dyslipidemia and hypertension. Hyperuricemia is gaining importance as cardiovascular risk factor and has role in renal and metabolic diseases. Our study was aimed to find out the prevalence of hyperuricemia and metabolic syndrome in type 2 DM and to evaluate association of hyperuricemia with metabolic syndrome.
Methods: This observational longitudinal study was carried out on 150 patients of type 2 DM patients for determination of hyperuricemia and components of metabolic syndrome.
Results: Metabolic syndrome was diagnosed in 68 patients (45.3%) with higher prevalence in males (53.4%) than females (33.9%). Hyperuricemia was found in 38 patients (25.3%) with higher prevalence in males (33%) than females (14.5%). Hyperuricemia and metabolic syndrome was found in 32 (21.3%) patients with higher prevalence among males (27.3%) than females (12.9%). The patients with hyperuricemia and metabolic syndrome compared to those without hyperuricemia and metabolic syndrome had higher mean age (63.16 versus 55), mean FBS (139.31 versus 117.23), mean duration of diabetes (12.66 versus 5.64), mean BMI (28.71 versus 24.61), systolic BP (128.50 versus 122.12), diastolic BP (80.63 versus 74.27), TG (176.28 versus 141.69) and lower HDL (39.63 versus 52.03).
Conclusions: Prevalence of hyperuricemia is higher in patients of type 2 diabetes with metabolic syndrome and is positively correlated with BMI, blood pressure and triglycerides and negatively correlated with HDL-C.
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