Comparison of two doses of Dexmedetomidine on hemodynamic parameters of patients undergoing spinal anesthesia

B. Srinivasulu Reddy, K. Surya


Background: Dexmedetomidine is considered as safe adjuvant as it does not cause depression of the respiratory system. Whether it can be used in the dose of 5 mcg or 10 mcg needs evaluation. Objective of the study was to compare two doses of dexmedetomidine on hemodynamic parameters of patients undergoing spinal anesthesia.

Methods: Present study was hospital based follow up study. 80 patients were studied who were of age 18-60 years. These patients were operated using spinal anesthesia. History in detail was taken. They were examined thoroughly and investigated. Informed written consent is taken. Two groups were made. One group with 30 patients received dexmedetomidine 5 mcg. Second group with 50 patients received 10 mcg dexmedetomidine.

Results: All baseline parameters were similar in two group patients. Heart rate at various intervals was also similar in two groups patients. Systolic blood pressure at various intervals was also similar in two groups patients. Diastolic blood pressure at various intervals was also similar in two groups patients. Highest level of sensory block was also similar in two groups patients. Patients in 5 mcg group had both the sensory and motor block more compared to patients in 10 mcg group. All other parameters were similar in two group of patients.

Conclusions: Dexmedetomidine in doses of 5 mcg and 10 mcg has been found to have similar effect on hemodynamic parameters of the patients. So, it can be used in any of these two doses without affecting the hemodynamic parameters.


Comparable, Dexmedetomidine, Groups, Heart rate, Hemodynamic parameters

Full Text:



Parameshwara G. Spinal, epidural to combined spinal epidural analgesia, the history of central neuraxial block. Indian J Anaesth. 2001;45(6):406-12.

Dureja GP, Jayalaxmi TS. Colloid preloading before spinal and epidural anaesthesia. Hospital Today. 2000;11:601-3.

Ghodki PS, Sardesai SP, Thombre SK. Evaluation of the effect of intrathecal clonidine to decrease shoulder tip pain in laparoscopy under spinal anaesthesia. Ind J anaesth. 2010;54(3):231.

Gustafsson LL, Schildt B, Jackobson K. Adverse effects of extradural and intrathecal opiates: report of a nationwide survey in Sweden. Brit J Anaesth. 1982;54:479-86.

Biswas BN, Rudra A, Bose BK, Nath S, Chakrabarty S, Bhattacharjee S. Intrathecal fentanyl with hyperbaric bupivacaine improves analgesia during caesarean delivery and in early post-operative period. Ind J Anaesth. 2002;46(6):469-72.

Sundnes KO, Vaagenes P, Skretting P, Lind B, Edstrom HH. Spinal analgesia with hyperbaric bupivacaine: effects of volume of solution. Brit J Anaesth. 1982;54(1):69-74.

Roussel JR, Heindel L. Effects of intrathecal fentanyl on duration of bupivacaine spinal blockade for outpatient knee arthroscopy. AANA J. 1999;67(4):337-43.

Gupta R, Bogra J, Verma R, Kohli M, Kushwaha JK, Kumar S. Dexmedetomidine as an intrathecal adjuvant for postoperative analgesia. Ind J Anaesth. 2011;55(4):347.

Al-Ghanem SM, Massad IM, Al-Mustafa MM, Al-Zaben KR, Qudaisat IY, Qatawneh AM, Abu-Ali HM. Effect of adding dexmedetomidine versus fentanyl to intrathecal bupivacaine on spinal block characteristics in gynecological procedures: a double blind controlled study. Am J Applied Sci. 2009;6(5):882.

Routray S, Ravi K, Mishra D. Effect of Intrathecal Dexmedetomidine and Fentanyl as adjuvant to hyperbaric bupivacaine for orthopaedic lower limb and lower abdominal procedures: a double blind control study. Ind J Clinic Anaesth. 2015;2(4):204-8.

Varghese LA, Taksande K. A comparison between intrathecal dexmedetomidine with hyperbaric bupivacaine and intrathecal fentanyl with hyperbaric bupivacaine in lower abdominal surgeries: a prospective double-blinded study. J Datta Meghe Institute of Med Sci Uni. 2017;12(2):99.

Tarbeeh GA, Mohamed AA. Effects of intrathecal bupivacaine-fentanyl versus bupivacaine-dexmedetomidine in diabetic surgical patients. Egypt J Anaesth. 2013;29(1):13-8.