Comparison of psychiatric morbidity and disease specific quality of life in patients of diabetes treated with insulin versus oral hypoglycemics


  • Nitin Raut Department of Psychiatry, Dr. B. R. Ambedkar Central railway hospital, Mumbai, Maharashtra, India
  • Deoraj Sinha Department of Psychiatry, T. N. Medical College and B.Y.L. Nair Ch. Hospital, Mumbai, Maharashtra, India
  • Alka Subramanyam Department of Psychiatry, T. N. Medical College and B.Y.L. Nair Ch. Hospital, Mumbai, Maharashtra, India



Diabetes, Insulin, Oral hypoglycemics, Disease specific quality of life


Background: Psychiatric co-morbidity along with other disease and treatment related factors including treatment modality (i.e. insulin versus oral agents) affect the quality of life of diabetic patients significantly. The aim and objectives of the study was to study psychiatric morbidity and quality of life and relationship between these factors in patients of type-2 diabetes being treated with insulin versus oral hypoglycemics.

Methods: A cross sectional study with patients of type-2 diabetes 50 each taking insulin and oral hypoglycemics was carried out in the endocrinology outpatient department and wards of the tertiary teaching municipal medical institute in Mumbai. Subjects were assessed using QOLID (quality of life instrument for Indian diabetic patients) and SCL-90R (symptoms checklist 90 revised). Software used was SPSS-19. Data was analyzed using Pearson’s bivariate correlation and unpaired t-test according to applicability.

Results: 76% of subjects on insulin while 82% on oral hypoglycemics had satisfactory quality of life. There was no statistically significant difference in the two groups on quality of life. (t= -1.130, p=0.261). 46% of patients on insulin and 40% on oral hypoglycemics had significant psychopathology. Highest scores were found on depression, somatization and obsessive compulsive symptoms in both groups; however there was no significant difference in the two groups on either global score or the subscales of SCL-90R. Increase in psychopathology was associated with decrease in quality of life (negative correlation) in diabetics as a whole (R= -0.748, p=0.000) as well as on all subscales. Female gender was associated with better quality of life while male gender, age, duration of illness, blood glucose levels and presence of associated complications with poor QOL.

Conclusion: Treatment modality does not seem to affect quality of life or psychopathology in diabetic patients and increased psychopathology is associated with poor quality life in them.


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