DOI: http://dx.doi.org/10.18203/2349-3933.ijam20192084

Association of microvascular complications of type 2 diabetes mellitus with ABO blood group

Geetika Gupta, Bhavna Langer, Tabinda Shah, Anil K. Gupta, Mumtaz Goni

Abstract


Background: Micro vascular complications are the major outcome of Type 2 Diabetes Mellitus progression, which reduces the quality of life and increases diabetic morbidity & mortality. As the incidence of type 2 diabetes is growing day by day; our search for its aetiology and pathogenesis is also ever growing to predict its risk factors and early screening for better care and prevention of its complications. Many studies have tried to link susceptibility of type 2 diabetes with ABO blood group though results have been inconsistent. The present study aims to analyse association of micro vascular complication with different blood groups if any.

Methods: A cross sectional study was conducted among patients of type 2 diabetes Mellitus in a tertiary care hospital. Determination of ABO and Rh status was done by standard slide method of agglutination. Detailed information about age, gender, BMI, duration of diabetes, age of onset of diabetes was noted with the help of a proforma. The records (clinical examination and investigations done by physician) were screened for type of micro vascular complications.

Results: Out of a total of 319 patients suffering from type 2 diabetes, 209 subjects (65.15%) had one or the other complications. A statistically significant (p=0.00) difference was observed between the presence or absence of complications in different blood groups. In patients with Blood group B, 76.14% presented with complications. Though Nephropathy was the most common complication observed among different blood groups, none of the type of micro vascular complication was found to be significantly associated with different blood groups.

Conclusions: The findings in our study suggest that although there was a significant association between presence or absence of complications and different blood groups, but this association was not significant for different types of complications.


Keywords


ABO blood group, Diabetes mellitus, Micro vascular complications, Type 2 diabetes

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References


International Diabetes Federation. The Diabetes Atlas; 2011. 5th Ed. Available at: http: //www.drsharma.ca/world-diabetes-atlas-5th-edition.html.

Harris M, Hadden WC, Knowler WC, Benett PH. Prevalence of diabetes and impaired glucose tolerance and plasma glucose levels in US. population aged 20-74. Diabetes. 1987;36:523-34.

Stratton IM, Adler AI, Neil HAW, Matthews DR, Manley SE, Cull CA, et al. Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study. BMJ. 2000;321(7258):405-12.

Daniels G. Human Blood Groups, Blackwell Science, Oxford, UK, 2nd Ed., chapter 2; 2002:7-98.

O’Donnell J, Laffan M. The relationship between ABO histoblood group, factor VIII and von willebrand factor. Transfus Med. 2001;11(4);343-51.

Garratty G, Dzik W, Issitt PD, Lublin DM, Reid ME, Zelinski T. Terminology for blood group antigens and genes-historical origins and guideline in the new millennium. Transfusions. 2000;40(4):477-89.

Huston AM, Atmar RL, Graham DY, Estes MK. Norwalk virus infection and disease is associated with ABO histo-blood group type. J Infect Dis. 2002;185(9):1335-7.

Paré G, Chasman Di, Kellogg M, Zee Ry, Rifal N, Badola S, et al. Novel association of ABO histo-blood group antigen with soluble ICAM-1: results of a genome-wide association study of 6, 578 women. PLoS Genet. 2008;4(7):e1000118.

Meigs JB, Hu FB, Rifai N, Manson JE. Biomarkers of endothelial dysfunction and risk of type 2 diabetes mellitus. JAMA. 2004;291(16):1978-86.

Orasanu G, Plutzky J. The pathologic continuum of diabetic vascular disease. J Am Collin Cardiol. 2009;53(5 Suppl);S35-42.

Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes care. Jan 2002;25(Suppl 1):S5-20.

Joint WHO/FAO Expert Consultation. Diet, Nutrition and The Prevention Of Chronic Diseases [Internet]. Geneva: World Health Organization; 2003:1-150.

Summary of revisions to the 2014 Clinical Practice Recommendations. Diabetes Care. 2014 Jan;37(Suppl 1):S4.

Adeghate E, Schattner P, Dunn E. An update on the etiology and epidemiology of diabetes mellitus. Ann N Y Acad Sci. 2006;1084:1-29.

Diabetes in the UK: Key statistics on diabetes. United Kingdom; 2010:1-21.

Cheung N, Mitchell P, Wong TY. Diabetes retinopathy. Lancet. 2010.10;376(9735):124-36.

Kapoor C, Shettar SS. Distribution of Blood Groups among Patients with Diabetes Mellitus and their secretor Status. Ind J of Pub Health Res and Dev. 2012;3(1):66-9.

Pontiroli AE, Calderara A, Bonisolli L, De Pasqua A, Maffi P, Margonato A, et al. Risk factors for micro- and macroangiopathic complications in type 2 diabetes: lack of association with acetylator phenotype, chlorpropamide alcohol flush and ABO and Rh blood groups. Diabete Metab. 1987 Jul-Aug;13(4):444-9.

Unal A, Kocyigit I, Yilmaz S, Eser B, Elmali F. The ABO blood Groups are related to Diabetic Nephropathy. Turk neph Dial Transpl. 2015;24(3):266-9.

Sushma TV, Krishnamurthy A. Study of relationship between ABO and Rh Blood group with Type 2 Diabetes mellitus and its complications- Is there any association? Int J Curre Advan Resea. July 2018;7(7):14150-2.

Richelle JK, Charles JE, Heather AL, Elizabeth HS. Evidence of Nephropathy and Peripheral Neuropathy in US Adults with Undiagnosed Diabetes. Ann Fam Med. 2006 Sep;4(5):427-32.

Arora GS, Chawla R, Ahuja CP. To Evaluate the Clinical Profile and Determine the Prevalence of Complications in Newly Detected Type 2 Diabetes Patients. J Diabetes Complicati. 1995;9;140-8.

Ballard DJ, Humphrey LL, Melton LJ 3rd, Frohnert PP, Chu PC, O'Fallon WM, Palumbo PJ. Epidemiology of persistent proteinuria in type II diabetes mellitus. Population-based study in Rochester, Minnesota. Diabetes. 1988 Apr;37(4):405-12.

Klein R. Hyperglycemia and microvascular and macrovascular disease in diabetes. Diabetes Care. 1995;18(2):258-68.

Chawla A, Chawla R, Bhasin GK, Soota K. Profile of adolescent diabetes in North Indian population. J Clin Diabetol. 2014;1(2):1-3.

Rema M, Ponnaiya M, Mohan V. Prevalence of retinopathy in non-insulin dependent diabetes mellitus at a diabetes centre in southern India. Diabetes Res Clin Pract. 1996 Sep;34(1):29-36.

Ramachandran A, Snehalatha C, Vijay v, Vishwanathan M. Diabetic Retinopathy at the time of diagnosis of NIDDM in South Indian Subjects. Diab Res Clin Pract. 1996;32(1-2):111-4.

Knuiman MW, Welborn TA, McCann VJ, Stanton KG. Prevalence of diabetic complication in relation to risk factors. Diabetes. 1986;35(12):1332-9.

Oguejiofor OC, Odenigbo CU, Oguejiofor CB. Evaluation of the effect of duration of diabetes mellitus on peripheral neuropathy using the United Kingdom screening test scoring system, bio-thesiometry and aesthesiometry. Niger J Clin Pract. 2010 Sep;13(3):240-7.