Serum uric acid level in type 2 diabetes mellitus


  • D. Vasantha Kalyani Department of General Medicine, Government Sivagangai Medical College, Sivagangai, Tamilnadu, India
  • M. Ilamaran Department of General Medicine, Government Sivagangai Medical College, Sivagangai, Tamilnadu, India
  • P. Suresh Kumar Department of General Medicine, Government Sivagangai Medical College, Sivagangai, Tamilnadu, India
  • Saranya Nagalingam Department of Anaesthesiology, Mahatma Gandhi Medical College and Research Institute, Sri Balaji Vidyapeeth University, Puducherry, India



Coronary artery disease, Duration of diabetes, Hypertension, Hyperuricemia, Obesity, Serum uric acid, Type 2 diabetes


Background: Diabetes mellitus is the most important risk factor associated with two to four fold increased incidence of coronary artery disease. The major risk factors for CAD are hypercholesterolemia, hypertension, diabetes mellitus, and cigarette smoking Objectives: To study the level of serum uric acid in type 2 diabetes mellitus and the correlation between elevated serum uric acid level and the component of metabolic syndrome like obesity, hypertension, dyslipidemia.

Methods: The study was done as descriptive analytical study among the diabetic patients in a tertiary care setting during the period January 2018 to February 2019. The inclusion and exclusion criteria were clearly defined and the study participants were recruited for the study after getting the informed consent. The socio demographic profile, clinical and laboratory data were collected from the blood sample obtained from the patients with the standardized procedures. Data was entered in Microsoft excel spread sheet and analyzed statistically using SPSS statistical software. Student ‘t’ test and Chi-square test values were applied for significance.

Results: Serum uric acid in the study population and control varied from 3.0 to 8.1 and 2.7 to 5.5 mg/dl respectively. The mean and standard deviation of uric acid among cases was 5.08±1.42 while in control it was 3.55±0.62 respectively. The serum uric acid level of diabetics was very much elevated compare with controls and it was highly significant. Significant correlation was noticed between serum uric acid and BMI as well as WHR. Elevated uric acid levels were significantly noticed among those with hypertension, dyslipidemia, coronary artery disease and chronicity of the diabetes.

Conclusions: Uric acid was significantly elevated in diabetic population and the mean value of serum uric acid level was higher in longer duration of diabetes, hypertension, dyslipidemia, central obesity which are the components of metabolic syndrome.


Mm G, Levine SA. Serum uric acid in relation to age and physique in health and in coronary heart disease. Ann Intern Med. 1951;34(6):1421-31.

Reaven GM. Role of insulin resistance in human disease. Diabetes. 1988;37(12):1595-607.

Alderman MH, Cohen H, Madhavan S, Kivlighn S. Serum uric acid and cardiovascular events in successfully treated hypertensive patients. Hypertension. 1999;34(1):144-50.

Ketker S, Ketker M, Bose S, Sharma KS. Ponderal index and serum uric acid levels in healthy medical students. J Assoc Phys Ind. 1979;27(6):531-3.

Healey LA, Caner JE, Bassett DR, Decker JL. Serum uric acid and obesity in Hawaiians. JAMA. 1966;196(4):364-5.

Rathmann W, Funkhouser E, Dyer AR, Roseman JM. Relations of hyperuricemia with the various components of the insulin resistance syndrome in young black and white adults: the CARDIA study. Ann Epidemiol. 1998;8(4):250-61.

Cannon PJ, Stason WB, Demartini FE, Sommers SC, Laragh JH. Hyperuricemia in primary and renal hypertension. New Engl J Med. 1966;275(9):457-64.

Mazzali M, Hughes J, Kim YG, Jefferson JA, Kang DH, Gordon KL, et al. Elevated uric acid increases blood pressure in the rat by a novel crystal-independent mechanism. Hypertension. 2001;38(5):1101-6.

Sánchez-Lozada LG, Tapia E, Avila-Casado C, Soto V, Franco M, Santamaría J, et al. Mild hyperuricemia induces glomerular hypertension in normal rats. Am J Physiol Renal Physiol. 2002;283(5):F1105-10.

Jossa F, Farinaro E, Panico S, Krogh V, Celentano E, Galasso R, et al. Serum uric acid and hypertension: the Olivetti heart study. J Hum Hypertens. 1994;8(9):677-81.

Tkác I, Bomba J, Cvanigová A. Uric acid a risk factor or atherosclerosis marker in type 2 diabetes?. Internal Med. 1990;36(8):763-8.

Bouvenot G, Bartolin R, Sciara M, Delboy C, Arnaud C. Serum uric acid and serum lipids. Statistical correlations. Report of 1000 cases. La Semaine Des Hop. 1980;56(5-6):263-4.

Verdecchia P, Schillaci G, Reboldi G, Santeusanio F, Porcellati C, Brunetti P. Relation between serum uric acid and risk of cardiovascular disease in essential hypertension: the PIUMA study. Hypertension. 2000;36(6):1072-8.






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