Clinical profile of seizure disorder in hospitalized patients
Keywords:Seizure disorder, EEG, CT scan, MRI
Background: Hughling Jackson in 1870 described first “seizures as intermittent derangement of central nervous system and abnormal and excessive discharge of central nervous tissue on muscles” and the same was refined further. Average incidence rate for epilepsy is 0.3 - 0.5% in patients.
Methods: A total of 100 patients admitted with sign and symptoms suggestive of seizure disorder in tertiary care hospital during the period of 1st December 2012 to 31st July 2014. A detailed clinical history, examination and investigation with following patients were included in study; (1) age of the patients above 13 years; (2) patient present with history of seizure the cross sectional observational study was carried out at Dr. V. M. Government Medical College, Solapur, Maharashtra, India.
Results: Generalized tonic clonic were the commonest type seen in 69 patients (69%) and cerebrovascular disease because seen in 25 patients (25%) is the second most common cause.
Conclusions: (1) Ring enhancing lesion were seen in 15% patients, among most common was tuberculoma that is seen in 10 patients and neurocysticercosis was seen in 5 patients; (2) cerebral tumour was seen in 4 patients; (3) EEG was abnormal in 31% cases of seizure and most common EEG abnormality was focal slow waves and (4) CT scan abnormality was seen in 47 cases (47%).
Adams RD and Victor. Principles of neurology. 7th Ed. New York, NY: McGraw-Hill ; 2001.
Daniel H. Lowenstein harrison`s principle of internal medicine. 11 th Edition. 3251-69.
Adoukonou T, Djagoun E, Tognon-Tchegnonsi F, Sego-Sounon D,Kouna-Ndouongo P, Houinato D. Prevalence of epilepsy in adults at Tourou, in northern Benin. Med Sante Trop. 2013;23(1):83-8.
Hamdy NA, Alamgir MJ, Mohammad EGE, Khedr MH, Fazili S. Profile of epilepsy in a regional hospital in Al Qassim, Saudi Arabia. Int J Health Sci (Qassim). 2014;8(3):247-55.
Sander JWAS, Hart YM, Johnson AL, Shorvan SD. National General Practice study of epilepsy: newly diagnosed epileptic Seizures in general population. Lancet. 1990;336:1271-4.
Hauser WA, Kurland LT, Annergen JF. Incidence of epilepsy and unprovoked seizure in rochestar, minnesota: 1935-1984. Epilepsia. 1993;34:453-68.
Shridharan R. Current Science. 2002;82(6):664-70.
Kalitha J, Pathak RN, Mohonata A. Late onset Epilepsy –Aetiolgical Aspects. JAPI. 1991;39(1).
Sethi PP, Wadia RS, Kiyawat DP, Ichaporia NR, Kothari SS, Sangle SA, et al. Ring or disc enhancing lesion in epilepsy in India. J Trop Med Hyg. 1994;97(6):347-53.
Pal DK. Arturo Corpio Review: Neurological aspect of tropical diseases. J neurol neurosurgery psychiatry. 2000;68:137-43.
Ramamurthi B. Tuberculoma of brain. Indian journal of Neurosurgery. 1956;18:452.
Washimkar SN, Holay MP, Fusey SM. Evaluation of focal seizure by computerized tomography. JAPI. 1996 , VOL 44,
Godbole VY, Gandhi GD, Parmar MC, Trivedi C, Kikani BJ, Dave NA. JAPI. 1996;44(12):946.
Young AC, Costanzi JB, Mohr PD, Forbes WS. Is routine computerised axial tomography in epilepsy worth while? Lancet. 1982;2(8313):1446-7.
Adams RD. and Victor M. Intracranial Neoplasm, Principle of Neurology, Mc Graw Hill, New York, 3rd Edition,1985.
Homes S, Ni XS, Dutta N. EEG, CT finding in patients in post ischaemic Seizures. J neuronal Sci. 1995;132(1)L:57-60.
Basu PK, Bandopadhyay S, Mukherjee. A Study of Adult onsetepilepsy. JAPI. 1993;41(12):817.
Gastut H. Computerized transverse axial tomography in epilepsy. Epilepsia. 1976;17:325-36.
Baheti R. Study of CT Scan and EEG in patients of Generalized Tonic Clonic Seizures and Partial seizures in western Rajasthan J. of Indain Academy of clinical medicine volume.2003;4(1):25-9.
Tendon PN, Pathak SN. Tuberculoma of CNS – Tropical neurology Ed. Spillance, J.D., London, Oxford, 1973.
Dam AM, Fuglsang –Fredensken A, Olsen SU, Dam M. Late Onset Epilepsy : aetilogies, types of seizure and value of Clinical Investigation, EEG and Computerized tomography scan. Epilepsia. 1985;26:227.