Study of risk factors associated with adverse outcome in a severe coronary artery disease (syntax score >22) with different therapeutic strategies


  • Vidur G. Karnik RCSM GMC Kolhapur, Maharashtra, India
  • Yogesh B. Patil RCSM GMC Kolhapur, Maharashtra, India
  • N. Pai KMC and H, Manglore, Karnataka, India
  • M. N. Bhat KMC and H, Manglore, Karnataka, India
  • R. L. Kamath KMC and H, Manglore, Karnataka, India
  • P Kamath KMC and H, Manglore, Karnataka, India
  • Rajesh Bhatt KMC and H, Manglore, Karnataka, India



Coronary artery disease, Microalbuminuria, SYNTAX score


Background: The specific question of whether PCI or surgical treatment offers any advantage over MT in patients with stable angina and multivessel disease remains unanswered. Objective of our research was to study various risk factors which interferes the outcome of various therapeutic procedures in coronary artery disease.

Methods: This was prospective observational study carried out in a tertiary care center from July 2014 to July 2016. A total of 98 subjects undergoing different therapeutic strategies were followed up. Risk factors which interferes the outcome of various therapeutic procedures in coronary artery disease (CAD) were studied.

Results: There was a significant difference in mean SYNTAX score (P = 0.003), urine micro albumin levels (P=0.006), and body mass index (0.046) between those who had MACE and who did not have MACE.

Conclusions: The urine micro albumin >30 mg/l and highest SYNTAX score were significantly associated with MACE at 1 year in subject with severe CAD.


Holmes DR, Schwartz RS, Webster MW. Coronary restenosis: what have we learned from angioFigurey?. J Am College Cardiol. 1991;17:14-22.

Nobuyoshi M, Kimura T, Nosaka H, Mioka S, Ueno K, Yokoi H, et al. Restenosis after successful percutaneous transluminal coronary angioplasty: serial angioFigureic follow-up of 229 patients. J Am College Cardiol. 1988;12(3):616-23.

Elezi S, Kastrati A, Pache J, Wehinger A, Hadamitzky M, Dirschinger J, et al. Diabetes mellitus and the clinical and angioFigureic outcome after coronary stent placement. J Am College Cardiol. 1998;32(7):1866-73.

McEvoy JW, Blaha MJ, Rivera JJ, Budoff MJ, Khan AN, Shaw LJ, et al. Mortality rates in smokers and nonsmokers in the presence or absence of coronary artery calcification. JACC: Cardiovascular Imaging. 2012 Oct 1;5(10):1037-45.

Shaw LJ, Raggi P, Callister TQ, Berman DS. Prognostic value of coronary artery calcium screening in asymptomatic smokers and non-smokers. Euro Heart J. 2006;27(8):968-75.

Musallam KM, Rosendaal FR, Zaatari G, Soweid A, Hoballah JJ, Sfeir PM, et al. Smoking and the risk of mortality and vascular and respiratory events in patients undergoing major surgery. JAMA Surg. 2013;148(8):755-62.

Suskin N, Sheth T, Negassa A, Yusuf S. Relationship of current and past smoking to mortality and morbidity in patients with left ventricular dysfunction. J Am Coll Cardiol. 2001;37(6):1677-82.

Hasdai D, Garratt KN, Grill DE, Lerman A, Holmes Jr DR. Effect of smoking status on the long-term outcome after successful percutaneous coronary revascularization. New Eng J Med. 1997;336(11):755-61.

Vlietstra RE, Kronmal RA, Oberman A, Frye RL, Killip T. Effect of cigarette smoking on survival of patients with angioFigureically documented coronary artery disease: report from the CASS registry. JAMA. 1986;255(8):1023-7.

Sianos G, Morel MA, Kappetein AP, Morice MC, Colombo A, Dawkins K, et al. The SYNTAX Score: an angioFigureic tool grading the complexity of coronary artery disease. Euro Intervention. 2005;1(2):219-27.

Carnero-Alcázar M, Castellanos LC, Guisasola JA, Carnicer JC, Alswies A, Ferrer ME, et al. SYNTAX Score is associated with worse outcomes after off-pump coronary artery bypass grafting surgery for three-vessel or left main complex coronary disease. J Thoracic Cardiovascular Surg. 2011;142(3): e123-32.

Tuttle KR, Puhlman ME, Cooney SK, Short R. Urinary albumin and insulin as predictors of coronary artery disease: an angioFigureic study. Am J Kidney Dis. 1999;34(5):918-25.






Original Research Articles