Seroprevalence of Hepatitis B and Hepatitis C in end-stage renal disease patients on maintenance hemodialysis: a single-center study from Bangladesh

Authors

  • S. M. Rahid Sarwar Lieutenant Colonel, Classified Specialist in Medicine, Combined Military Hospital, Rangpur, Bangladesh
  • A. K. M Mijanur Rahman Colonel, Classified Specialist in Medicine and Nephrology, Combined Military Hospital, Dhaka, Bangladesh
  • S. M. Mijanur Rahman Colonel, Classified Specialist in Medicine and Gastroenterology, Combined Military Hospital, Dhaka, Bangladesh
  • Shahjada Selim Department of Endocrinology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
  • A. B. M. Kamrul Hasan Department of Endocrinology, Mymensingh Medical College Hospital, Mymensingh, Bangladesh

DOI:

https://doi.org/10.18203/2349-3933.ijam20193293

Keywords:

End-stage renal disease, Hemodialysis, Hepatitis B, Hepatitis C

Abstract

Background: Hepatitis B virus (HBV) and Hepatitis C virus (HCV) infections are important causes of morbidity and mortality in hemodialysis (HD) patients. The aim of this study was to estimate the seroprevalence of HBV and HCV among end-stage renal disease (ESRD) patients on maintenance HD.

Methods: This cross-sectional study was conducted in the hemodialysis unit of a military hospital of Bangladesh from October 2013 to March 2014 and included 141 maintenance HD patients. All patients were assessed by HBsAg and anti-HCV antibodies in addition to routine liver function tests.

Results: The age range of the study subjects were 18-70 years, and the majority (85.11%) were male. Among them 22 (15.60%) were positive for anti HCV, 5(3.5%) were positive for HBsAg, and 3 patients (2.13%) were positive for both HBsAg and anti-HCV. The duration of hemodialysis was higher in anti-HCV positive patients (49±24 vs. 25±10 months, p <0.05) than anti-HCV negative ones. Anti-HCV positive patients in this study received a higher number of blood transfusion (units) than anti-HCV negative patients (7.5±4.3 vs. 2.8±1.7 units, p <0.05). HBsAg positive patients also received a higher number of blood transfusion (units) than HBsAg negative patients (8.2±3.1 vs. 3.2±1.2 units, p <0.05).

Conclusions: Hepatitis C virus was the major form of hepatitis in HD patients in this study. The duration of HD was higher in anti-HCV positive patients; the numbers of blood transfusion units were higher in patients positive for HCV and HBV than the negative ones.

References

Demirtürk N, Demirdal T, Toprak D, Altindiş M, Aktepe OC. Hepatitis B and C virus in West-Central Turkey: seroprevalence in healthy individuals admitted to a university hospital for routine health checks. Turk J Gastroenterol Off J Turkish Soc Gastroenterol. 2006;17(4):267-72.

Bini EJ, Perumalswami PV. Hepatitis B virus infection among American patients with chronic hepatitis C virus infection: Prevalence, racial/ethnic differences, and viral interactions. Hepatol. 2010;51:759-66.

Souza KP, Luz JA, Teles SA, Carneiro MA, Oliveira LA, Gomes AS, et al. Hepatitis B and C in the hemodialysis unit of Tocantins, Brazil: serological and molecular profiles. Memories Oswaldo Cruz Institute. 2003;98(5):599-603.

Zacks SL, Fried MW. Hepatitis B and C and renal failure. Infectious Dis Clinic North Am. 2001;15(3):877-99.

Karoney MJ, Siika AM. Hepatitis C virus (HCV) infection in Africa: a review. Pan African Med J. 2013;14(1).

Aghakhani A, Banifazl M, Eslamifar A, Ahmadi F, Ramezani A. Viral hepatitis and HIV infection in hemodialysis patients. Hepat Mon. 2012;12:463-64.

Saha D, Agarwal SK. Hepatitis and HIV infection during haemodialysis. J Ind Med Assoc. 2001;99(4):194-9.

Kane M. Global programme for control of hepatitis B infection. Vaccine 1995;13:S47-9.

Al-Mahtab M, Rahman S, Karim F, Foster G, Solaiman S. Epidemiology of hepatitis C virus in Bangladeshi general population. Bangabandhu Sheikh Mujib Med Univ J. 2009;2(1):14-7.

Bhaumik P, Debnath K. Prevalence of hepatitis B and C among haemodialysis patients of Tripura, India. Euro J Hepato-Gastroentero. 2012;2(1):10-3.

Ahmed H, Rahman H, Rashid HU. Prevalence of Hepatitis C virus in maintenance hemodialysis patients-a prospective study. Bangladesh Renal J. 2003; 22(2):39-43.

Hossain RM, Iqbal MM, Rahman ZF, Sultana R, Rahman MH, Islam MN, et al. Hepatitis B and Hepatitis C virus infection among end stage renal disease patients on maintenance hemodialysis, their family members and dialysis staffs-a prevalence study. BIRDEM Med J. 2018;8(1):42-6.

Rahman AM. Hepatitis B and Hepatitis C Virus Infection in Haemodialysis Patients. J Armed Forces Med Coll Bangladesh. 2014;10(2):66-70.

Perumal A, Ratnam PV, Nair S, Anitha P, Illangovan V, Kanungo R. Seroprevalence of hepatitis B and C in patients on hemodialysis and their antibody response to hepatitis B vaccination. J Current Res Sci Med. 2016;2(1):20.

Malhotra R, Soin D, Grover P, Galhotra S, Khutan H, Kaur N. Hepatitis B virus and hepatitis C virus co-infection in hemodialysis patients:a retrospective study from a tertiary care hospital of North India. J Natural Sci Biol Med. 2016;7(1):72.

Chawla NS, Sajiv CT, Pawar G, Pawar B. Hepatitis B and C virus infections associated with renal replacement therapy in patients with end stage renal disease in a tertiary care hospital in India–prevalence, risk factors and outcome. Ind J Nephrol. 2005;15(4):205-13.

Agarwal SK, Dash SC, Irshad M. Hepatitis C virus infection during haemodialysis in India. J Assoc Phys Ind. 1999;47(12):1139-43.

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Published

2019-07-24

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Original Research Articles