DOI: http://dx.doi.org/10.18203/2349-3933.ijam20193292

Clinical manifestations in calotropis poisoning: a prospective study in Government General Hospital Nalgonda, India

C. Yadavendra Reddy

Abstract


Background: Calotropis procera commonly known as Madar is common shrub all over India. Its chemical component Calotropin, which is derived from latex is known to cause injury to eyes and oral mucosa. Toxic manifestations following accidental ingestion are mostly gastrointestinal. This study was aimed at studying the various clinical manifestations of Calotropis poisoning in patients admitted to GGH Nalgonda.

Methods: This prospective observational study was done from Feb 2019 to May 2019.All patients both male and female admitted to GGH Nalgonda during this period were studied. Patients below 12 years, pregnant women and patients with earlier gastritis, hepatitis, stomatitis were excluded from the study. The study was carried out in all patients fulfilling the inclusion and exclusion criteria.

Results: A total of 60 patients 45 females and 15 males presented during the study period. Most of the patients presented with abdominal pain 15 (25%), hepatitis 10 (16.6%), stomatitis 12 (20%), vomiting 8 (13.3%), diarrhea 6 (10%), hyperkalemia 3 (5%), tachycardia 5 (8.3%), convulsion 1 (1.6%).

Conclusions: It was observed from the study that most of the patients had abdominal pain as the major symptom. Stomatitis was the second most common symptom. It was observed consumption of the toxin in lesser quantities produced these symptoms in large quantities produced tachycardia, hyperkalemia and convulsions.


Keywords


Calotropin, Convulsions, Gastritis, Hepatitis, Oral mucosa, Tachycardia

Full Text:

PDF

References


Punia PG. A review on varieties of C. procera and C. giganta-gjrmi. 2013 May, 2(5).

Huber-H Asclepiadaceae. In: A revised handbook of flora of ceylon. Aemrind Publishing Company private limited New Delhi; 1985(4): 73-79.

Hussein HI, Kamel A, Zaid MA, El Sabae H, Saleh MA. Uscharin, the most potent molluscidal compound tested against land snails. J Chem Virol. 1994;20(1):135-40.

K.R.Srikanta murthy Astanga Samgraha of Vagbhata, Varanasi; Chaukhamb orientalia, 9th edition. 2005.

Modi P. Jaising, Medical Jurisprudence and Toxicolgy 23rd edition first reprint,2001 Dr. K. Mathiharan and Dr. Amit Patnaik, Lexis, nexis, New Delhi; 2006: 234-238.

Tomar VP, Agarwal PK, Agarwal BL. Toxic iridocyclitis caused by Calotropis. Indian J Ophthalmol. 1970;18(1):15.

Dr. Dole A.Vilas Rasashastra; Varanasi; Chaukambha Sanskrit Pratisthan 1st edition. 2004: 423-425.

Sathandas Sharma, Mothilal Banarsi das, Rasatarigini, Varanasi; 1st edition. 2015: 743.

Samar KB, Arup B, Ayan M, Prashant S. Ocular toxicity by latex of Calotropis procera. Indian J Ophthalmol. 2009;57:232-4.

Singh V. Calotropis boon or bane?. Open J Stomatol. 2012;2(02):149.

Singh H, Kumar S, Dewan S, Kumar VL. Inflammation induced by latex of Calotropis procera-a new model to evaluate anti-inflammatory drugs. J Pharmacological Toxicological Methods. 2000;43(3):219-24.

Shivkar YM, Kumar VL. Histamine mediates the pro-inflammatory effect of latex of Calotropis procera in rats. Mediators of Inflammation. 2003;12(5):299-302.

Kupchan SM, Knox JR, Kelsey JE, Renauld JS. Calotropin, a cytotoxic principle isolated from Asclepias curassavica L. Sci. 1964;146(3652):1685-6.