Serum uric acid and lipid profile in diabetic retinopathy in rural Haryana, India


  • Poonam Agrawal Department of Biochemistry, Army College of Medical sciences, Cantt, Delhi, India
  • Sumita Sethi Department of Ophthalmology, BPS Government Medical College for women, Haryana, India
  • V. S. Reddy Department of Biochemistry, BPS Government Medical College for women, Haryana, India
  • Sonika Lamba Department of Medicine, BPS Government Medical College for women, Haryana, India



Diabetic retinopathy, Serum uric acid, Lipid profile


Background: Diabetic retinopathy is associated with severe ophthalmic morbidity. Present study aimed to analyse serum uric acid (UA) and lipid profile in newly diagnosed type-II diabetes mellitus (DM) who presented with and without retinopathy.

Method: A total of 57 subjects were recruited for the present study and were divided in three groups. Sixteen type-II DM patients without retinopathy (group-I), 18 type-II DM patients with retinopathy (group-II) and 23 age and sex matched healthy controls (group-III). Five ml of fasting venous blood sample was collected under proper aseptic precautions from median cubital vein and analyzed for fasting blood sugar, HbA1c, UA, total cholesterol (TC), triglycerides (TG), high density lipoproteins (HDL) by standard enzymatic methods. Very low density lipoproteins (VLDL) and low density lipoptoteins (LDL) was calculated using Frieldwald’s formula. FBS, HbA1c, UA, total cholesterol, triglycerides, HDL, LDL and VLDL levels were compared between different groups. Statistical analysis was done using SPSS software and student‘t’ test.

Results: A statistically significant lower value of mean HDL was found in group-I and II than group-III (p=0.01 and 0.00 respectively). Mean HbA1c and mean FBS significantly correlated with UA (r=-0.45, p=0.01 and r=-0.39, p=0.02 respectively) in group-I and II. A deranged HDL profile and a significant correlation between glycemic control and HbA1cand UA were thus found in diabetic subjects (with or without retinopathy).

Conclusions: An insight into the deranged biochemical profile could assist in predicting onset of complications of diabetes.


Kiani J, Habibi Z, Tajziehchi A, Moghimbeigi A, Dehghan A, Azizkhani H. Association between serum uric acid level and diabetic peripheral neuropathy (A case control study). Caspian J Intern Med. 2014;5(1):17-21.

Landmesser U, Hornig B, Drexler H. Endothelial dysfunction in hypercholesterolemia: mechanisms, pathophysiological importance, and therapeutic interventions. Semin Thromb Hemost. 2000;26(5):529-37.

Wu L, Fernandez-Loaiza P, Sauma J, Hernandez-Bogantes E, Masis M. Classification of diabetic retinopathy and diabetic macular edema. World J Diabetes. 2013;4(6):290-4.

Navin S, Krishnamurthy N, Ashakiran S, Dayanand CD. The association of hypomagnesaemia, high normal uricaemia and dyslipidaemia in the patients with diabetic retinopathy. J Clin Diagn Res. 2013;7(9):1852-4.

Cetin EN, Bulgu Y, Ozdemir S, Topsakal S, Akın F, Aybek H et al. Association of serum lipid levels with diabetic retinopathy. Int J Ophthalmol. 2013;6(3):346-9.

Daskalopoulou SS, Athyros VG, Elisaf M, Mikhailidis D. The impact of serum uric acid on cardiovascular outcomes in the LIFE study. Kidney Int. 2004;66(4):1714-5.

Benarous R, Sasongko MB, Qureshi S, Fenwick E, Dirani M, Wong TY et al. Differential association of serum lipids with diabetic retinopathy and diabetic macular edema. Invest Ophthalmol Vis Sci. 2011;52(10):7464-9.

Tuomilehto J, Zimmet P, Wolf E, Taylor R, Ram P, King H. Plasma uric acid level and its association with diabetes mellitus and some biologic parameters in a biracial population of Fiji. Am J Epidemiol. 1988;127(2):321-36.

Herman JB, Medalie JH, Goldbourd U. Diabetes, prediabetes and uricemia. Diabetologia. 1976;12:(1):47-52.

Kodama S, Sugawara A, Saito K, Yachi Y, Asumi M, Totsuka K, et al. Association between serum uric acid and development of type 2 diabetes. Diabetes care. 2009;(32):1737-42.

Galvan QA, Natali A, Baldi S, Frascerra S, Sanna G, Ciociaro D. Effect of insulin on uric acid excretion in humans. Am J Physiol. 1995;268(1 Pt 1):E1-5.

He BB, Wei L, Gu YJ, Han JF, Li M, Liu YX. Factors associated with diabetic retinopathy in chinese patients with type 2 diabetes mellitus. Int J Endocrinol. 2012;2012:157940.

Tapp RJ, Shaw JE, Harper CA, de Courten MP, Balkau B, McCarty DJ, et al. Aus Diab Study Group. The prevalence of and factors associated with diabetic retinopathy in the Australian population. Diabetes Care. 2003;26(6):1731-7.

Zheng W. Factor analysis of diabetic retinopathy in Chinese patients. Diabetes Res Clin Pract. 2011;92(2):244-52.

Ferris FL, Chew EY, Hoogwerf BJ. Serum lipids and diabetic retinopathy. Early Treatment Diabetic Retinopathy Study Research Group. Diabetes Care. 1996;19(11):1291-3.

Klein BE, Moss SE, Klein R, Surawicz TS. The wisconsin epidemiologic study of diabetic retinopathy. XIII. Relationship of serum cholesterol to retinopathy and hard exudate. Ophthalmology. 1991;98(8):1261-5.






Original Research Articles