Published: 2019-07-24

Study of the post tuberculosis lung diseases and the impact of various patient and disease related factors on its occurrence

Jayasri Helen Gali, Harsha Vardhana Varma, Aruna Kumari Badam


Background: More than fifty percent of the cured cases of pulmonary tuberculosis develop some form of chronic pulmonary dysfunction. It can present with varying degrees of lung damage, ranging from minimum functional abnormalities to severe forms of dysfunction that can be an important cause of death. Objective of the study to identify the various Post Tuberculosis Lung Diseases (PTBLDs) and to study impact of the patient and disease related factors on its occurrence.

Methods: Cross-sectional, observational study was conducted in 134 adult, post tuberculosis patients, aged between 18-65 years, who have completed at least one year after the end of anti-tubercular treatment. All symptomatic post TB lung disease patients coming to the pulmonology out-patient clinic at the Apollo Institute of Medical sciences and Research were included in the study.

Results: Majority were more than 50 years (35.3%) and males (59.4%). Majority were from urban areas (70.7%), low social class (72.2%), and unskilled workers (56.4%). Most common symptom was cough in 74.4% cases. Majority of the cases had symptoms from one week to one month i.e. 47.4%. Only eight cases were found out to be very prompt in reporting their symptoms. 39 cases had some or the other co-morbidity. Current chest X-ray status was normal in only three cases. Mean FEV1 was 1.38 which increased to 1.52; mean FVC was 1.23 which increased to 1.58; mean FEV1/FVC was 67.37 which increased to 72.76 after giving the bronchodilator. 78(58.6%) cases had obstructive and 27(20.3%) had restrictive lung disease. In 30 cases the disease was reversible. Majority of the cases were of pulmonary fibrosis followed by bronchiectasis.

Conclusion: Further studies are needed to develop approaches for the prevention, care and treatment of patients with post TBLD.


Bronchiectasis, Chronic obstructive pulmonary disease, Post TB lung disease, Pulmonary fibrosis, Tuberculosis

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Ravimohan S, Kornfeld H, Weissman D, Bisson GP. Tuberculosis and lung damage: from epidemiol. to pathophysiol. Euro Resp Rev. 2018;27(147):1700-77.

Menezes AM, Hallal PC, Perez-Padilla R, Jardim JR, Muino A, Lopez MV, et al. Tuberculosis and airflow obstruction: evidence from the PLATINO study in Latin America. Euro Resp J. 2007;30(6):1180-5.

World Health Organization. Global Action Plan for the prevention and control of non-communicable diseases, Geneva, Switzerland: World Health Organization. 2013:2013-2020.

Beran D, Zar HJ, Perrin C, Menezes AM, Burney P. Burden of asthma and chronic obstructive pulmonary disease and access to essential medicines in low-income and middle-income countries. Lancet Resp Med. 2015 Feb1;3(2):159-70.

Allwood BW, Myer L, Bateman ED. A systematic review of the association between pulmonary tuberculosis and the development of chronic airflow obstruction in adults. Respiration. 2013;86(1):76-85.

Verma SK, Kumar S, Narayan KV, Sodhi R. Post Tubercular Obstructive Airway Impairment. Indian J Allergy Asthma Immunol. 2009;23(2):95-9.

Menezes A, Wehrmeister FC, Perez-Padilla R, Viana KP, Soares C et al. The PLATINO study: description of the distribution stability and mortality according to the Global Initiative for Chronic Obstructive Lung Disease Classification from 2007 to 2017. Int J Chron Obstruct Pulmon Dis. 2017;12:1491-501.

Zakaria MW, Moussa HA. Chronic obstructive pulmonary disease in treated pulmonary tuberculosis patients. Airways Health Dis 2015;9(1):10-3.

Munda MK, Pal S, Sit NK. Correlation between Pulmonary Tuberculosis, Bronchiectasis and Chronic obstructive pulmonary disease in Burdwan District of West Bengal, India. IOSR J Dental Med Sci. 2018;17(9):29-31.

Baig IM, Saeed W, Khalil KF. Post tuberculosis chronic obstructive pulmonary disease. J Coll Physicians Surg Pak. 2010;20(8):542-4.