Clinical profile, morbidity and mortality among swine flu (H1N1) infected patients: 2015 Gwalior, Madhya Pradesh pandemic, India


  • Sanjay Dhawale Department of Medicine, G R Medical College, Gwalior, India
  • Satyam Jayant Department of Medicine, G R Medical College, Gwalior, India



Influenza infection, H1N1, Swine flu


Background: Influenza is known to cause annual seasonal epidemics in Asian subcontinent. Our study assessed the clinical profile, factors influencing the response, prognosis and outcome in H1N1 positive patients during February- March 2015. We aimed to understand the epidemiology and patterns of the disease so that the high risks groups could be identified.

Methods: Medical records of the patients who were admitted during Feb-March 2015, as a suspected case to the swine flu ward of J A Hospital and G R Medical College, Gwalior, India were manually retrieved and retrospectively studied. H1N1 positive patients, who were diagnosed clinically and confirmed by RT-PCR method, were included for analysis.

Results: Out of 208 patients were admitted for suspicion of swine flu influenza and underwent testing out of which 88 (42.30%) were found to be positive for H1N1. Most common (37.40%) affected age group was 20-30 years. Females were more involved (62.5%), out of which 20% were antenatal. The common presenting symptoms were cough, fever, breathlessness. Overall case fatality ratio was 4.45%.

Conclusions: Patients with influenza like illness should not panic as many of them become negative for H1N1. In our area prevalence of H1N1 was high in young and females. Most of the patients recovered with symptomatic treatment and oseltamivir therapy. Proper prevention steps, personal hygiene and admission to designated swine flu ward can be helpful in preventing the spread in the community.


Singh M, Sharma S. An epidemiological study of recent outbreak of Influenza A H1N1 (Swine Flu) in western rajasthan region of India. J Med Allied Sci. 2013;3(2).

Prakash G. Epidemiological and clinical profile of patients with swine flu (Influenza A, H1N1) attending Guru Govind singh Government Hospital, Jamnagar, India. J Res Med Den Sci. 2013;1(1):1-6.

Biswas DK, Kaur P, Murhekar M, Bhunia R. An outbreak of pandemic influenza A (H1N1) in kolkata, west bengal, India, 2010. Indian J Med Res. 2012;135:529-33.

Lamb RA. The gene structure and replication of influenza virus. Annu Rev Biochem. 1983;52:467-06.

Brankston G, Gitterman L, Hirji Z. Transmission of influenza A in human beings. Lancet Infect Dis. 2007;4:257-65.

Mukherjee A, Roy T, Agrawal AS, Sarkar M, Lal R, Chakrabarti S et al. Prevalence and epidemiology of pandemic H1N1 strains in hospitals of Eastern India. J. Public Health Epidemiol. 2010;2(7):171-4.

Tanna K, Vegad MM, Soni ST, Patel F, Amin BK, Kachhadiya K. Patients with swine flu on mechanical ventilator and its outcome at Civil Hospital, Ahmedabad. Int J Med Sci Public Health. 2015;4(10):1383-7.

Choudhry A, Singh S, Khare S, Rai A, Rawat DS, Aggarwal RK et al. Emergence of pandemic 2009 influenza A H1N1, India. Indian J Med Res. 2012; 135:534-7.

Gurav YK, Pawar SD, Chadha MS, Potdar VA, Deshpande AS, Koratkar SS et al. Pandemic influenza A(H1N1) 2009 outbreak in a residential school at Panchgani, Maharashtra, India. Indian J Med Res. 2010;132:67-71.

Broor S, Sullender W, Fowler K, Gupta V, Widdowson MV, Krishnan A et al. Demographic Shift of Influenza A (H1N1) pdm09 during and after Pandemic, Rural India. Emerg Infect Diseases. 2012;18(9):1472-5.






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