DOI: http://dx.doi.org/10.18203/2349-3933.ijam20193280

Clinical and laboratory profile of dengue fever: a retrospective study

Sachin N. Solanke, Abhay S. Pohekar, Jayshree A. Pohekar

Abstract


Background: The global incidence of dengue has grown dramatically in recent decade. Half of world’s population is now at risk. India represents significantly a larger burden, accounting for nearly 34% of the global burden of dengue infection. Dengue infection needs to be addressed as a single disease with different clinical presentations ranging from asymptomatic conditions to severe clinical courses that may lead to high morbidity and mortality.

Method: This was retrospective observational study carried out during period of July 2017 to April 2018, to study clinical profile and laboratory parameters in dengue fever patients. Confirmed dengue cases having NS1 positive or IgM positive or having both NS1 and IgM positive or dengue ELISA reactive, having minimum one CBC reports done and not having other confounding factor such as co-infection, bone marrow diseases etc. that may altered clinical and laboratory results are included in study. Statistical analysis was done by SPSS software version 18.0.

Results: Out of 48 confirmed dengue cases maximum patients 58.33% was from young age group (21 to 40 years) with M:F ratio was 2.43:1. Fever was found in 100% patients, in order of frequency followed by headache, bodyache, abdominal pain, weakness, retro-orbital pain, anorexia, dry cough, back pain, nausea, diarrhoea, vomiting, rash, joint pain, itching and malena.NS1was positive in 41.67% cases, dengue ELISA in 31.25%, IgM was positive in 20.83% cases, and both NS1 and IgM positive were in 4.17% cases. TLC count was low 35.42%, high in 12.50% of cases and remaining had normal TLC count. Platelet count was ranged between normal platelet counts to thrombocytopenia. One case had platelet count less than 20000. Out of 48 patients, 2 (4.17%) had malena.

Conclusion: In this study, fever was found in all patients, and headache, body ache and weakness were common symptoms, but significant number of patients also had gastroentstinal and respiratory symptoms like abdominal pain, nausea, diarrhea, vomiting and dry cough. TLC count ranging from normal TLC, leukopenia to leucocytosis. Large number of patients had low platelet count that shows dengue fever had varied clinical presentation.

 


Keywords


Clinical profile, Dengue fever, Dengue haemorrhagic fever, Laboratory profile, Retrospective study, Thrombocytopenia

Full Text:

PDF

References


World Health Organization, Regional Office for South-East Asia, ‎2016. Dengue Bulletin. Vol-39. World Health Organization, Regional Office for South-East Asia. Available at: http://www.who.int/iris/handle/10665/255696. Accessed December 2016.

WHO. Dengue and Severe Dengue. Available at: www.who.int/news-room/fact-sheets/detail. Accessed 10 April 2018.

World Health Organization, 2012‎. Global strategy for dengue prevention and control 2012-2020. World Health Organization. Available at: http://www.who.int/iris/handle/10665/75303. Accessed 10 April 2018.

Mid Term Plan for prevention and control of Dengue and Chikungunya. Directorate of National Vector Borne Diseases Control Programme, Directorate General of Health Services, Ministry of Health & Family Welfare, Government of India,2011. Available at: https://mohfw.gov.in/sites/default/files/5201617.pdf Accessed 10 April 2018.

Baruah K, Biswas A, Suneesh K, Dhariwal AC. Dengue fever: Epidemiology and clinical pathogenesis. Major tropical diseases: Public health perspective. Goa: Broadway publishing House; 2014:255-271.

Bhatt S, Gething PW, Brady OJ, Messina JP, Farlow AW, Moyes CL, et al. The global distribution and burden of dengue. Nature. 1998;496:504-7.

Brady OJ, Gething PW, Bhatt S, Messina JP, Brownstein JS, Hoen AG et al. Refining the global spatial limits of dengue virus transmission by evidence-based consensus. PloS Negl Trop Dis. 2012;6(8):e1760.

Dash AP, Bhatia R, Kalra NL. Dengue in South-East Asia: An appraisal of case management and vector control. Dengue Bulletin. 2012;36:45-8.

Gupta E, Dar L, Kapoor G, Broor S. The changing epidemiology of dengue in Delhi, India. Virol J. 2006;3:92.

Vairo F, Mboera LE, De Nardo P, Oriyo NM, Meschi S, Rumisha SF, et al. Clinical, Virologic, and Epidemiologic Characteristics of Dengue Outbreak, Dar es Salaam, Tanzania, 2014. Emerg Infect Dis. 2016;22(5):895-9.

Yagnik H Chhotala, Chetal M Suva. A Study of clinical profile of dengue fever in a tertiary care hospital. Int J Res Med Sci. 2016;4(10):4500-4.

Sharma S and Sharma SK. Clinical profile of DHF in adults during 1996 outbreak in Delhi, India. Dengue Bulletin. 1998;22:20-7.

Nimmagadda SS, Mahabala C, Boloor A, Raghuram PM, Nayak UA. Atypical Manifestations of Dengue Fever-Where Do We Stand to Day?. J Clin Diagn Res. 2014;8(1):71-3.