Evaluate the relation between microalbuminuria and with other biochemical parameters related to complications of type 2 diabetes

S. A. Vaidya, B. B. Gupta, Mahak Bhandari, Simran Behl, Susmit Kosta


Background: Type 2 Diabetes (T2D) with microalbuminuria have increased risk of progression to overt proteinuria, and after some time, renal failure. It is the leading cause of end-stage renal disease as a sequalae of Diabetic Nephropathy (DN) and an independent risk factor for Cardio-Vascular Diseases (CVD). Initial finding for microalbuminuria can prevent long-term complications. The objective of the present investigation was to study the relation between microalbuminuria and with other biochemical parameters related to complications of T2D.

Methods: This observational study was conducted among 150 T2D patients attending to the OPD, Department of General Medicine during the time period March 2018 to April 2019. The patients were interviewed for socio-demographic details, history and clinical examination and subjected to blood investigations and Electrocardiogram (ECG).

Results: Microalbuminuria was present in 47(31.3%) of the diabetics. The age group 48-63 years 18(38.3%), male gender 33(70.2%) duration of diabetes >5 years 11(23.4%). The smokers, Diabetic Retinopathy, Peripheral Neuropathy, Ischemic Heart Disease, SBP 160-170 mmHg, DBP 95-100 mmHg and 100-105 mmHg, BMI 30-35 Kg/m2, TG >250 mg/dl, LDL >110 mg/ dl and HbA1c 7.5-9 % showed a greater odds ratio and significant association (p<0.001) with microalbuminuria.

Conclusions: There was an increased prevalence of microalbuminuria among patients with T2D. It also showed a significant association of major microvascular and macrovascular complications of T2D and microalbuminuria.


Biochemical Parameters, Microalbuminuria, Type 2 diabetes

Full Text:



Naqvi SAJ. Nephrology services in Pakistan; Nephrol Dial Transplant. 2000; 15(6):769-71.

Molitch ME, Rutledge B, Steffes M, Cleary P. Renal insufficiency in the absence of albuminuria among adults with Type 1 diabetes in the Diabetes Control and Complications Trial (DCCT) /Epidemiology of Diabetes Interventions and Complications (EDIC) Study. ADA Annual Meeting 2006 (Abstract 23-OR).

Xia F, Liu G, Shi Y, Zhang Y. Impact of microalbuminuria on incident coronary heart disease, cardiovascular and all-cause mortality: a meta-analysis of prospective studies. Int J Clin Exp Med. 2015;8(1):1-9.

Parving HH, Gall MA, Skott P. Prevalence and causes of microalbuminuria in patients with non-insulin dependent diabetic patients. Kidney Int. 1992;41(4):758-62.

Taneja V, Sircar S, Kansra U, Lamba IM. Microalbuminuria in normotensive non-insulin dependent diabetic subjects’ associations and predictions. J Diabetes Assoc Ind. 1997;37:30-6.

Tagle R, Acevedo M, Vidt DG. Microalbuminuria: Is it a valid predictor of cardiovascular risk? Cleveland Clin J Medicine, 2003;70(3):255-61.

American Diabetes Association. Standards of medical care for patients with. Diabetes mellitus. Diabetes Care. 2003; 26(1):S33-50.

Rodicio JL, Campo C, Ruilope LM. Microalbuminuria in essential hypertension. Kidney Int Suppl. 1998;54(68):S51-4.

Ruilope LM, Rodicio JL. Clinical relevance of proteinuria and microalbuminuria. Curr Opin Nephrol Hypertens. 1993;2(6):962-7.

Ruilope LM, Segura J. Predictors of the evolution of microalbuminuria. Hypertension. 2006; 48(5):832-3.

Metcalf P, Baker J, Scott A, Wild C, Scragg R, Dryson E. Albuminuria in people at least 40 years old: Effect of obesity, hypertension, and hyperlipidemia. Clin Chem. 1992; 38(9):1802-8.

Ghai R, Verma ND, Goel A, Bhatnagar MK, Kapoor P, Vashishta A. Microalbuminuria in non insulin dependent diabetes and essential hypertension: A marker of severe disease. J Assoc Physicians India. 1994; 42(10):771-4.

Ahmedani MY, Hydrie MZ, Iqbal A, Gul A, Mirza WB, Basit A. Prevalence of microalbuminuria in type 2 diabetic patients in Karachi: Pakistan a multi-center study. J Pak Med Assoc. 2005; 55(9):382-6.

Varghese A, Deepa R, Rema M, Mohan V. Prevalence of microalbuminuria in type 2 diabetes mellitus at a diabetes centre in southern India. Postgrad Med J. 2001;77(908):399-402.

Dinneen SF, Gerstein HC. The association of microalbuminuria and mortality in non-insulin dependent diabetes mellitus. A systematic overview of the literature. Arch Intern Med. 1997; 157(13):1423-8.

Ritz E, Orth SR. Nephropathy in patients with type 2 diabetes mellitus. N Eng J Med. 1999;341(15):1127-33.