Clinical profile and etiological causes of pancytopenia: a study in a tertiary care hospital
Keywords:Aplastic anemia, Bone marrow biopsy, Megaloblastic anemia, Pancytopenia, Weakness
Background: Pancytopenia is a condition which involves the presence of anemia, leucopenia and thrombocytopenia. Symptoms of pancytopenia include fatigue, bleeding, dyspnea, and increased tendency to infections. The evaluation of pancytopenia is by complete blood picture and peripheral blood smear including that of reticulocytes. Bone marrow examination is extremely helpful.
Methods: Demographic details were collected from all the patients and physical examination was done. The patients were asked to undergo biochemical investigations, chest X rays and USG of abdomen. Smears were taken from peripheral blood as well as bone marrow biopsy and stained. Invasive procedure such as bone marrow biopsy is done if needed.
Results: A predominance of males was seen over females and 11-30 years age group was the most affected. The most common cause was megaloblastic anemia followed by aplastic anemia and tuberculosis. The most common symptom were fatigue, dyspnea, fever and bleeding.
Conclusion: Early identification of this disease would help in early planning for management thereby improving the survival rates.
Khunger JM, Arulselvi S, Sharma U, Ranga S, Talib VH. Pancytopenia a clinicohaematological study of 200 cases. Indian J Pathol Microbiol. 2002;45:375-9.
Shimamura A, Alter BP. Inherited aplastic anemia syndrome. In: Wintrobe's clinical hematology. Philadelphia: Lippincott Williams & Wilkins; 2008: 11073-11261.
Jha A, Sayami G, Adhikari RC, Panta AD, Jha R. Bone marrow examination in cases of pancytopenia. J Nepal Med Assoc. 2008 Jan 1;47(169):12-7.
Yadav BS, Varma A, Kiyawat P. Clinical profile of pancytopenia: a tertiary care experience. Int J Bioass. 2014 Dec 31;4(1):3673-7.
Tilak V, Jain R. Pancytopenia- A Clinico-hematologic Analysis of 77 cases. Indian J Pathol. 1999; 42(4): 399-404.
Nanda A, Basu S, Marwaha N. Bone marrow trephine biopsy as an adjunct to bone marrow aspiration. JAPI. 2002;50:893-5.
Gayathri BN, Rao KS. Pancytopenia: A clinico hematological study. Physicians Lab J. 2011;3:15-20.
Naseem S, Varma N, Das R, Ahluwalia J, Sachdeva US, Marwaha RK. Pediatric patients with bicytopenia/pancytopenia: Review of etiologies and clinic hematological profile at a tertiary centre. IJPM. 2011;54(1):75-80.
Prasad BH, sarode S, Kadam DB. Clinical profile of Pancytopenia in adults. Int J Sc Res. 2013;July;2(7): 355-7.
Dasgupta S, Mandal PK, Chakrabarti S. Etiology of Pancytopenia: An Observation from a Referral Medical Institution of Eastern Region of India J Lab Physicians. 2015 Jul-Dec; 7(2): 90-5
Makheja KD, Maheshwari BK, Arain S, Kumar S, Kumari S. The common causes leading to pancytopenia in patients presenting to tertiary care hospital. Pak J Med Scie. 2013 Sep;29(5):1108-11.
Khunger JM, Arunselvi S, Sharma U, Ranga S, Talib VH. Pancytopenia- a clinico-hematological analysis of 200 cases. Indian J Pathol Microbiol. 2002;45(3):375-9.
Agarwal R, Bharat V, Gupta BK, Jain S, ansal R, Choudhary A, et al. Clinical and hematological profile of pancytopenia. International Journal of Clinical Biochemistry and Research, January-March 2015;2(1):48-53.
Tilak V, Jain R. Pancytopenia- A Clinico-hematologic Analysis of 77 cases. Indian J Pathol 1999;42(4):399-404.
Khodke K, Marwah S, Buxi G, Yadav RB, Chaturvedi NK. Bone Marrow Examination in Cases of Pancytopenia. J Academy Clin Med. 2001; 2(1-2):55-9.
Jha A, Sayami G, Adhikari RC, Panta AD, Jha R. Bone Marrow Examination in Cases of Pancytopenia. J Nepal Med Assoc. 2008;47(169): 12-7.
Kumar R, Kalra SP, Kumar H, Anand AC, Madan M. Pancytopenia - A six year study. JAPI. 2001;49: 1079-81.
Memon S, Shaikh S, Nizamani MAA. Etiological spectrum of pancytopenia based on bone marrow examination in children. J Coll Physicians Surg Pak. 2008;18(3):163-7.
Tareen SM, Bajwa MA, Tariq MM, Babar S, Tareen AM. Pancytopenia in two national ethnic groups of Baluchistan. J Ayub Med Coll Abottabad. 2011; 23(2):82-6.
Gamal AH, Safa AR. Patterns of pancytopenia in Yemen. Turk J Hematol. 2008;25(2):71-4.