Impact of blood group in dengue: a study
Keywords:Blood counts, Blood group, Dengue, Prognosticator
Background: Dengue can result in high mortality. Several studies have shown an association of blood groups with the severity of dengue. In our study we attempt to associate the prevalence of blood groups with the known hematological prognosticators and thus derive its impact on the severity of dengue. We aim to study the patterns and prevalence of different ABO blood groups in dengue fever.
Methods: A total of 100 serologically proven dengue cases over a month’s period in November 2016 were recruited for our study. Their relevant hematological data (obtained by automated haematology analyser and peripheral smears) and blood grouping results were recorded and analyzed.
Results: The age range was 5 months to 65 years with a slight male predominance. Analysis of the blood group patterns showed prevalence of O group (42%) followed by A and B group (27% each). B group was more prevalent in children (34%) and females (31%) with dengue.
The patients with B group showed increased derangement in hematological parameters namely higher number of cases with B group showed rise in haematocrit (59%), an increased number of cases with leucopenia (56%), higher proportion of cases with lymphocytosis (45%) and severe thrombocytopenia (74%) when compared to the other blood groups.
Conclusions: Our study shows that blood groups can impact severity of dengue and that B group is a risk factor for severity hence, such individuals warrant close supervision especially in the presence of other risk factors.
Patel K, Patel D, Das V. Hematological Parameters and Its Utility in Dengue Fever: A Prospective Study. (IJSR). 2016;5(4):1077-9.
Hadinegoro S. The revised WHO dengue case classification: does the system need to be modified?. Paediatrics and International Child Health. 2012;32(sup1):33-8.
Khode V, Ruikar K, Kabbin G. Association of ABO Rh blood group with dengue fever and dengue hemorrhagic fever: A case-control study. J Applied Hematol. 2013;4(4):145-8.
Shetty A, Kasukurti P, Vijaya C, Jyalakshmi VJ. The reactive lymphocyte: a morphological indicator of Platelet counts in Dengue seropostive patients. Annals of Pathol Lab Med. 2016;3(3):A217-21.
Mehta RC, Goswami HM, Katara RK, Patel PS, Parikh UV, Vegad MM, et al. Importance of Complete Blood Count and Peripheral Smear Examination In Early Diagnosis Of Dengue Patients. J Infects Dis Letters. 2013;2(1):22-4.
Achalkar VG. Dengue: A clinicopathological study of 50 cases. J Evolu Med Dental Scien. 2013;2(48):9380-85.
Pawitan JA. Dengue virus infection: predictors for severe dengue. Acta Med Indones. 2011 Apr;43(2):129-35.
Liumbruno GM, Franchini M. Beyond immunohaematology: the role of the ABO blood group in human diseases. Blood Transfusion. 2013;11(4):491-9.
Joseph L, Pizzorno. Non transfusion significance of ABO & ABO Associated Polymorphs. Textbook of Natural Medicine, chapter 43, Table 43-6; 2013:364-365.
Anstee D. The relationship between blood groups and disease. Blood. 2010;115(23):4635-43.
Panda AK, Panda SK, Sahu AN, Tripathy R, Ravindran B, Das BK. Association of ABO blood group with severe falciparum malaria in adults: case control study and meta-analysis. Malaria J. 2011 Dec;10(1):309.
Kalayanarooj S, Gibbons RV, Vaughn D, Green S, Nisalak A, Jarman RG, et al. Blood group AB is associated with increased risk for severe dengue disease in secondary infections. J Infect Disea. 2007 Apr 1;195(7):1014-7.
Bulugahapitiya DU, Satarasinghe RL. Preponderance of blood group B among dengue fever patients with serious complications in a tertiary care hospital. Ceylon Medical J. 2011 Aug 22;48(3).
Muruganantha K, Thirunavukkarasu K, Subramaniyam S. The association between blood groups and dengue and dengue haemorrhagic fever. Proceedings of the Peradeniya Univ International Research Sessions. 2014;18(5):458.
Souza LJ, Pessanha LB, Mansur LC, Souza LA, Ribeiro MB, Silveira MD, et al. Comparison of clinical and laboratory characteristics between children and adults with dengue. Brazilian J Infect Disea. 2013 Feb;17(1):27-311.
Rao C, Shetty J. Frequency of abo and rhesus (d) blood groups in dakshina kannada district of karnataka - a study from rural tertiary care teaching hospital in south india. Nitte University J Health Scien. 2014;4(3):57.
Yacoub S, Wills B. Predicting outcome from dengue. BMC Med. 2014;12(1):147.
Sellahewa KH. Haematological disturbances in dengue Haemorrhagic fever-its pathogenesis and management perspectives. J Hematol Oncol Resea. 2015 Jan 23;1(3):15.
Jameel T, Mehmood K, Mujtaba G, Choudhry N, Afzal N, Paul RF. Changing haematological parameters in dengue viral infections. J Ayub Medical College Abbottabad. 2012 Mar 1;24(1):3-6.
Jampangern W, Vongthoung K, Jittmittraphap A, Worapongpaiboon S, Limkittikul K, Chuansumrit A, et al. Characterization of atypical lymphocytes and immunophenotypes of lymphocytes in patients with dengue virus infection. Asian Pacific J Alle and Imm. 2007 Mar 1;25(1):27.
Cooling L. Blood groups in infection and host susceptibility. Clin Microbiol Reviews. 2015 Jul 1;28(3):801-70.